Imodium (Loperamide) (İmodium 2 mg) and Zitromax (Azithromycin) 500 mg (Zitromax 500 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Azithromycin may affect loperamide through P-glycoprotein inhibition and adds a separate QT-related concern.
Clinical significance and safety
Imodium (Loperamide) and Zitromax (Azithromycin) 500 mg: Azithromycin may affect loperamide through P-glycoprotein inhibition and adds a separate QT-related concern. The loperamide prescribing information advises avoiding combinations with other established QT-prolonging medicines. Excessive doses and electrolyte losses during diarrhoea make the risk especially important. Heart disease, a slow pulse and low potassium or magnesium can increase concern. A clinician determines whether ECG or electrolyte checks are needed. Fainting or new irregular palpitations require urgent assessment.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.