Midodrine (Midodrine (Midodrin)) and Solriamfetol (Sunosi): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Blood-pressure-raising effects may add with midodrine and solriamfetol.
Clinical significance and safety
Midodrine and Solriamfetol (Sunosi): Midodrine may produce excessive blood pressure, particularly while lying down. Solriamfetol also carries a precaution with medicines that increase blood pressure or heart rate. The exact combination has not been studied to quantify its risk. A prescriber should assess avoidance or close monitoring and review non-prescription decongestants.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.