Cyclobenzaprine and Lustral (sertraline) (Lustral 50 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Combined serotonergic effects may increase the risk of serotonin syndrome.
Clinical significance and safety
Cyclobenzaprine and Lustral (sertraline): Combined serotonergic effects may increase the risk of serotonin syndrome. Urgent assessment is needed for a new combination of agitation or confusion, fever, marked sweating, tremor or abnormal muscle movements. The warning does not provide a pair-specific incidence or establish that toxicity is inevitable.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.