Indomethacin and Clopidogrel (Plavix 75 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
An antiplatelet medicine and a systemic NSAID can increase bleeding.
Clinical significance and safety
Indomethacin and Clopidogrel (Plavix 75 mg): Monitoring for gastrointestinal and other bleeding may be needed. The combination is not automatically prohibited in every patient; cardiovascular benefit and bleeding risk must be considered together. Do not stop antiplatelet treatment to take a painkiller. Substantial bleeding, vomiting blood or black stools needs urgent assessment.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.