Prozac (fluoxetine) (Prozac 20 mg) and Zolpidem: interaction and safety

Interaction mechanism

Visual hallucinations have been reported when zolpidem is combined with certain antidepressants. Other centrally acting medicines may increase zolpidem-related sedation and psychomotor impairment. In a multiple-dose study, fluoxetine slightly prolonged zolpidem's half-life.

Clinical significance and safety

Prozac (fluoxetine) and Zolpidem: Visual hallucinations have been reported when zolpidem is combined with certain antidepressants. Other centrally acting medicines may increase zolpidem-related sedation and psychomotor impairment. In a multiple-dose study, fluoxetine slightly prolonged zolpidem's half-life. Drowsiness, dizziness, reduced coordination and falls can be more likely. Driving and other hazardous tasks require particular caution when affected. The class warning does not mean that every combination is contraindicated or that each pair has been tested in a separate clinical trial. Changes in exposure can affect tolerability or treatment response. The prescriber must check the exact inhibitor, formulation, dose and timing against the cited product information; doses should not be adjusted without that review. Reported hallucinations do not establish how frequently the event occurs or prove causality in every patient. New hallucinations or severe confusion require medical review. The fluoxetine study finding should not be presented as a major, proven exposure increase for every antidepressant. Ask a pharmacist or prescriber to review the full medicine list before adding or changing treatment.

Using this information

This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.