Amiloride and Ketorolac: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
A systemic NSAID can reduce the response to a potassium-sparing diuretic, impair kidney function and increase potassium.
Clinical significance and safety
Amiloride and Ketorolac: Check a systemic NSAID with the prescriber or pharmacist before adding it. Renal and potassium problems are particularly documented with indomethacin; other systemic NSAIDs carry a class precaution. Kidney function, electrolytes and the desired diuretic response should be assessed. Do not increase the diuretic yourself.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.