Apalutamide and Felodipine: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Apalutamide enzyme induction can reduce exposure to felodipine.
Clinical significance and safety
With Apalutamide and Felodipine, felodipine may have less effect because apalutamide induces the enzymes that metabolise it. The product information recommends considering an alternative when possible or checking for loss of effect if treatment continues. The clinician should assess blood pressure and angina control and make any adjustment; do not increase the dose yourself.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.