Apalutamide and Clopidogrel (Plavix 75 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
CYP2C8 inhibition may increase apalutamide and active-moiety exposure.
Clinical significance and safety
With Apalutamide and Clopidogrel (Plavix 75 mg), monitor apalutamide tolerability. The EMA product information identifies clopidogrel among relevant CYP2C8 inhibitors and does not require an automatic initial apalutamide dose change for this interaction. A clinician may consider a later change according to tolerability; report adverse effects instead of altering treatment yourself.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.