Apalutamide and Crestor (Rosuvastatin) (Crestor 20 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Apalutamide induction of BCRP and OATP1B1 can reduce rosuvastatin exposure.
Clinical significance and safety
Apalutamide with Crestor (Rosuvastatin) may reduce the effect of rosuvastatin. The product information recommends assessing the clinical effect of transporter substrates when used with apalutamide. The prescriber should review cholesterol control and decide whether an adjustment is appropriate. Do not change the cholesterol medicine yourself; an effect on one transporter substrate does not quantify the effect on all others.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.