Bedaquiline and Sotalol: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Additional QTc prolongation may increase torsades de pointes or ventricular-arrhythmia risk.
Clinical significance and safety
Bedaquiline and Sotalol: Additional QTc prolongation may increase torsades de pointes or ventricular-arrhythmia risk. Heart disease, a slow pulse and low potassium or magnesium can increase concern. A clinician determines whether ECG or electrolyte checks are needed. Fainting or new irregular palpitations require urgent assessment.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.