Chlorpromazine and Dronedarone (Multaq) (Dronedarone (Dronedaron)): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Systemic QT-prolonging effects may add; low potassium and a slow heart rate increase concern.
Clinical significance and safety
Chlorpromazine and Dronedarone (Multaq): Systemic QT-prolonging effects may add; low potassium and a slow heart rate increase concern. The cited product information recommends avoiding the relevant QT-risk combination; it does not make every antipsychotic pair an absolute contraindication. Heart disease, a slow pulse and low potassium or magnesium can increase concern. A clinician determines whether ECG or electrolyte checks are needed. Fainting or new irregular palpitations require urgent assessment.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.