Darolutamide and Sotalol: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Androgen-deprivation-related QT effects can combine with a QT-prolonging medicine.
Clinical significance and safety
Darolutamide with Sotalol should be evaluated for heart-rhythm risk, with ECG and electrolyte assessment where the clinician considers it appropriate. The EMA source calls for careful evaluation rather than treating this pair as automatically contraindicated. Seek urgent help for palpitations or fainting and do not change either prescribed medicine yourself.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.