Darolutamide and Atorvastatin (Lipitor 20 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Darolutamide inhibition of BCRP and OATP transporters can increase exposure to atorvastatin.
Clinical significance and safety
With Darolutamide and Atorvastatin (Lipitor 20 mg), increased atorvastatin exposure is possible. The darolutamide product information recommends considering an alternative where appropriate and monitoring for adverse effects of relevant transporter substrates. The treating team should plan any adjustment. Report new muscle pain or weakness promptly and do not independently replace a prescribed statin.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.