Aleve 220 mg (Naproxen Sodium) and Enalapril: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Systemic NSAIDs can reduce ACE-inhibitor or ARB antihypertensive effects and impair renal function in susceptible patients.
Clinical significance and safety
Aleve 220 mg (Naproxen Sodium) and Enalapril: Older age, dehydration, diuretics and pre-existing renal impairment increase concern. The clinician may monitor blood pressure, kidney function and potassium as appropriate. Fluid advice must account for heart and kidney conditions. Check non-prescription NSAIDs with the pharmacist or prescriber; do not increase or stop prescribed medicines yourself.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.