Enzalutamide and Isavuconazole: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Strong CYP3A4/5 induction can markedly reduce isavuconazole exposure.
Clinical significance and safety
Enzalutamide with Isavuconazole is contraindicated under the EMA isavuconazole product information because strong CYP3A4/5 induction can make antifungal treatment ineffective. The prescribers should select an appropriate alternative and coordinate any treatment transition. Do not discontinue a cancer or antifungal medicine yourself.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.