Pimozide and Prozac (fluoxetine) (Prozac 20 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Specified SSRI interactions or strong CYP2D6 inhibition can increase pimozide exposure or QT-related risk.
Clinical significance and safety
Pimozide and Prozac (fluoxetine): Specified SSRI interactions or strong CYP2D6 inhibition can increase pimozide exposure or QT-related risk. This combination is contraindicated under the cited pimozide product information. It requires prompt prescriber or pharmacist review; changing doses without that review is not an appropriate workaround. Changes in exposure can affect tolerability or treatment response. The prescriber must check the exact inhibitor, formulation, dose and timing against the cited product information; doses should not be adjusted without that review. Ask a pharmacist or prescriber to review the full medicine list before adding or changing treatment.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.