Posaconazole and Seroquel (quetiapine) (Seroquel 25 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Strong CYP3A inhibition can markedly increase quetiapine exposure.
Clinical significance and safety
Posaconazole and Seroquel (quetiapine): Strong CYP3A inhibition can markedly increase quetiapine exposure. Changes in exposure can affect tolerability or treatment response. The prescriber must check the exact inhibitor, formulation, dose and timing against the cited product information; doses should not be adjusted without that review. Ask a pharmacist or prescriber to review the full medicine list before adding or changing treatment.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.