Ribociclib and Seroquel (quetiapine) (Seroquel 25 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Moderate-to-strong CYP3A inhibition can increase quetiapine exposure.
Clinical significance and safety
The current EMA ribociclib product information explicitly lists quetiapine among CYP3A substrates whose concomitant administration should be avoided. This applies to Ribociclib with Seroquel (quetiapine). The extent of CYP3A inhibition depends on the ribociclib regimen; the psychiatric medicine’s own product information must also be considered. Specialists should coordinate any alternative without abrupt self-directed discontinuation.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.