Aldactone (Spironolactone) (Aldactone 25 mg) and Triamterene: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Combining potassium-sparing diuretics can cause severe, potentially fatal hyperkalaemia.
Clinical significance and safety
Aldactone (Spironolactone) and Triamterene: The reviewed amiloride and triamterene labels prohibit concurrent use with another potassium-sparing diuretic, including spironolactone. Have the prescriber check the medicine list. Weakness, palpitations or fainting needs urgent assessment. Do not add potassium or independently change the regimen.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.