{"id":12382,"date":"2026-11-02T23:22:56","date_gmt":"2026-11-02T20:22:56","guid":{"rendered":"https:\/\/www.ortaakarsu.net\/?ism_drug=macitentan"},"modified":"2026-11-02T23:22:56","modified_gmt":"2026-11-02T20:22:56","slug":"macitentan","status":"publish","type":"ism_drug","link":"https:\/\/www.ortaakarsu.net\/?ism_drug=macitentan","title":{"rendered":"Macitentan"},"content":{"rendered":"<p>Masitentan, eri\u015fkin pulmoner arteriyel hipertansiyonunda tek ba\u015f\u0131na veya ba\u015fka PAH tedavileriyle kullan\u0131lan bir endotelin resept\u00f6r antagonistidir. Karaci\u011fer, hemoglobin ve gebelik g\u00fcvenli\u011fi a\u00e7\u0131s\u0131ndan izlem gerekir.<\/p>\n<details>\n<summary>Kaynaklar ve belge kapsam\u0131<\/summary>\n<ul>\n<li><a href=\"https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/opsumit-epar-product-information_en.pdf\" rel=\"nofollow noopener\" target=\"_blank\">Opsumit Summary of Product Characteristics<\/a> \u2014 EMA product-information update 23\/04\/2026<\/li>\n<li><a href=\"https:\/\/www.nobel.com.tr\/cmsfiles\/turkey\/products\/masipah-10-mg-film-kapli-tablet-short-product-info-1.pdf?v=42\" rel=\"nofollow noopener\" target=\"_blank\">MAS\u0130PAH 10 mg K\u0131sa \u00dcr\u00fcn Bilgisi<\/a><\/li>\n<li><a href=\"https:\/\/www.janssenlabels.com\/package-insert\/product-monograph\/prescribing-information\/OPSUMIT-pi.pdf\" rel=\"nofollow noopener\" target=\"_blank\">Opsumit US Prescribing Information<\/a> \u2014 4\/2025<\/li>\n<li><a href=\"https:\/\/www.fda.gov\/drugs\/drug-interactions-labeling\/healthcare-professionals-fdas-examples-drugs-interact-cyp-enzymes-and-transporter-systems\" rel=\"nofollow noopener\" target=\"_blank\">FDA examples of drugs that interact with CYP enzymes and transporter systems<\/a><\/li>\n<li><a href=\"https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/kisqali-epar-product-information_en.pdf\" rel=\"nofollow noopener\" target=\"_blank\">Kisqali (ribociclib) EU Summary of Product Characteristics<\/a><\/li>\n<\/ul>\n<\/details>\n","protected":false},"excerpt":{"rendered":"<p>Masitentan, eri\u015fkin pulmoner arteriyel hipertansiyonunda tek ba\u015f\u0131na veya ba\u015fka PAH  [&#8230;]<\/p>\n","protected":false},"featured_media":0,"template":"","ism_etken_madde":[1546],"class_list":["post-12382","ism_drug","type-ism_drug","status-publish","hentry","ism_etken_madde-masitentan"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/ism_drug\/12382","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/ism_drug"}],"about":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/types\/ism_drug"}],"version-history":[{"count":0,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/ism_drug\/12382\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12382"}],"wp:term":[{"taxonomy":"ism_etken_madde","embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fism_etken_madde&post=12382"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}