{"id":12402,"date":"2026-11-02T23:22:58","date_gmt":"2026-11-02T20:22:58","guid":{"rendered":"https:\/\/www.ortaakarsu.net\/?ism_drug=ribociclib"},"modified":"2026-11-02T23:22:58","modified_gmt":"2026-11-02T20:22:58","slug":"ribociclib","status":"publish","type":"ism_drug","link":"https:\/\/www.ortaakarsu.net\/?ism_drug=ribociclib","title":{"rendered":"Ribociclib"},"content":{"rendered":"<p>Ribosiklib, belirli meme kanserlerinde endokrin tedaviyle kullan\u0131lan bir CDK4\/6 inhibit\u00f6r\u00fcd\u00fcr. QT uzamas\u0131 ve doza ba\u011fl\u0131 CYP3A inhibisyonu nedeniyle e\u015flik eden ila\u00e7lar\u0131n dikkatle se\u00e7ilmesi gerekir.<\/p>\n<details>\n<summary>Kaynaklar ve belge kapsam\u0131<\/summary>\n<ul>\n<li><a href=\"https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/kisqali-epar-product-information_en.pdf\" rel=\"nofollow noopener\" target=\"_blank\">Kisqali \u2014 EMA product information, Annex I SmPC<\/a><\/li>\n<li><a href=\"https:\/\/www.farmanova.com.tr\/sites\/farmanova_com\/files\/Valamor200mgFilmKapliTablet-KUB.pdf\" rel=\"nofollow noopener\" target=\"_blank\">VALAMOR 200 mg film kapl\u0131 tablet K\u00dcB<\/a> \u2014 25.12.2024; K\u00dcB b\u00f6l\u00fcm 10<\/li>\n<li><a href=\"https:\/\/www.fda.gov\/drugs\/drug-interactions-labeling\/healthcare-professionals-fdas-examples-drugs-interact-cyp-enzymes-and-transporter-systems\" rel=\"nofollow noopener\" target=\"_blank\">FDA examples of drugs that interact with CYP enzymes and transporter systems<\/a><\/li>\n<li><a href=\"https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/xtandi-epar-product-information_en.pdf\" rel=\"nofollow noopener\" target=\"_blank\">Xtandi \u2014 EMA product information, Annex I SmPC<\/a><\/li>\n<li><a href=\"https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/erleada-epar-product-information_en.pdf\" rel=\"nofollow noopener\" target=\"_blank\">Erleada \u2014 EMA product information, Annex I SmPC<\/a><\/li>\n<\/ul>\n<\/details>\n","protected":false},"excerpt":{"rendered":"<p>Ribosiklib, belirli meme kanserlerinde endokrin tedaviyle kullan\u0131lan bir CDK4\/6 inhibit\u00f6r\u00fcd\u00fcr.  [&#8230;]<\/p>\n","protected":false},"featured_media":0,"template":"","ism_etken_madde":[1556],"class_list":["post-12402","ism_drug","type-ism_drug","status-publish","hentry","ism_etken_madde-ribosiklib-suksinat"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/ism_drug\/12402","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/ism_drug"}],"about":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/types\/ism_drug"}],"version-history":[{"count":0,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/ism_drug\/12402\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12402"}],"wp:term":[{"taxonomy":"ism_etken_madde","embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fism_etken_madde&post=12402"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}