{"id":14817,"date":"2026-11-04T18:08:49","date_gmt":"2026-11-04T15:08:49","guid":{"rendered":"https:\/\/www.ortaakarsu.net\/?page_id=14817"},"modified":"2026-11-04T18:08:49","modified_gmt":"2026-11-04T15:08:49","slug":"english-interaction-abrocitinib-digoxin-berk-0-25-mg","status":"publish","type":"page","link":"https:\/\/www.ortaakarsu.net\/?page_id=14817","title":{"rendered":"Abrocitinib and Digoxin (Digoxin Berk 0.25 mg): interaction and safety"},"content":{"rendered":"<h2>Interaction mechanism<\/h2>\n<p>P-glycoprotein inhibition can increase digoxin exposure.<\/p>\n<h2>Clinical significance and safety<\/h2>\n<p>Digoxin Berk 0.25 mg contains digoxin, a P-glycoprotein substrate with a narrow therapeutic window. Abrocitinib can increase exposure to susceptible P-glycoprotein substrates; the prescriber may need concentration monitoring or a regimen review. Nausea, visual symptoms or rhythm disturbances merit prompt assessment rather than self-adjustment.<\/p>\n<h2>Using this information<\/h2>\n<p>This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Digoxin Berk 0.25 mg contains digoxin, a P-glycoprotein substrate with a narrow therapeutic window. Abrocitinib can increase exposure to susceptible P-glycoprotein substrates;\u2026<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-14817","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages\/14817","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=14817"}],"version-history":[{"count":0,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages\/14817\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=14817"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}