{"id":14994,"date":"2026-11-04T18:09:06","date_gmt":"2026-11-04T15:09:06","guid":{"rendered":"https:\/\/www.ortaakarsu.net\/?page_id=14994"},"modified":"2026-11-04T18:09:06","modified_gmt":"2026-11-04T15:09:06","slug":"english-interaction-bactrim-forte-tablet-lamivudine","status":"publish","type":"page","link":"https:\/\/www.ortaakarsu.net\/?page_id=14994","title":{"rendered":"Bactrim Forte (Co-trimoxazole) (Bactrim Forte Tablet) and Lamivudine: interaction and safety"},"content":{"rendered":"<h2>Interaction mechanism<\/h2>\n<p>Trimethoprim can inhibit renal transport involved in lamivudine elimination, increasing lamivudine exposure.<\/p>\n<h2>Clinical significance and safety<\/h2>\n<p>The trimethoprim component of this co-trimoxazole product can increase lamivudine exposure. At the usual co-trimoxazole exposure studied, this was not considered clinically significant and generally did not require lamivudine adjustment; renal impairment and high-dose treatment require separate review. Do not change an HIV regimen on the basis of this record alone.<\/p>\n<h2>Using this information<\/h2>\n<p>This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The trimethoprim component of this co-trimoxazole product can increase lamivudine exposure. At the usual co-trimoxazole exposure studied, this was not considered clinically si\u2026<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-14994","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages\/14994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=14994"}],"version-history":[{"count":0,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages\/14994\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=14994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}