{"id":15356,"date":"2026-11-04T18:09:36","date_gmt":"2026-11-04T15:09:36","guid":{"rendered":"https:\/\/www.ortaakarsu.net\/?page_id=15356"},"modified":"2026-11-04T18:09:36","modified_gmt":"2026-11-04T15:09:36","slug":"english-interaction-daridorexant-digoxin-sandoz-0-25-mg","status":"publish","type":"page","link":"https:\/\/www.ortaakarsu.net\/?page_id=15356","title":{"rendered":"Daridorexant and Digoxin (Digoxin Sandoz 0.25 mg): interaction and safety"},"content":{"rendered":"<h2>Interaction mechanism<\/h2>\n<p>P-glycoprotein inhibition may increase exposure to a narrow-therapeutic-index substrate.<\/p>\n<h2>Clinical significance and safety<\/h2>\n<p>Daridorexant may increase exposure to digoxin, the active ingredient in Digoxin, through P-glycoprotein inhibition. The label advises caution with narrow-therapeutic-index P-gp substrates. A prescriber should assess whether monitoring or a treatment change is needed; toxicity is not inevitable in every patient.<\/p>\n<h2>Using this information<\/h2>\n<p>This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Daridorexant may increase exposure to digoxin, the active ingredient in Digoxin, through P-glycoprotein inhibition. The label advises caution with narrow-therapeutic-index P-g\u2026<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-15356","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages\/15356","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=15356"}],"version-history":[{"count":0,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages\/15356\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=15356"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}