{"id":15443,"date":"2026-11-04T18:09:44","date_gmt":"2026-11-04T15:09:44","guid":{"rendered":"https:\/\/www.ortaakarsu.net\/?page_id=15443"},"modified":"2026-11-04T18:09:44","modified_gmt":"2026-11-04T15:09:44","slug":"english-interaction-darunavir-lipex-20-mg","status":"publish","type":"page","link":"https:\/\/www.ortaakarsu.net\/?page_id=15443","title":{"rendered":"Darunavir and Simvastatin (Lipex 20 mg): interaction and safety"},"content":{"rendered":"<h2>Interaction mechanism<\/h2>\n<p>CYP3A inhibition markedly increases exposure to the named sensitive medicine.<\/p>\n<h2>Clinical significance and safety<\/h2>\n<p>For ritonavir-boosted darunavir (PREZISTA\/ritonavir), this named combination is contraindicated because exposure can rise enough to cause serious toxicity. The prescriber must review another plan; unboosted darunavir is not an equivalent alternative.<\/p>\n<h2>Using this information<\/h2>\n<p>This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>For ritonavir-boosted darunavir (PREZISTA\/ritonavir), this named combination is contraindicated because exposure can rise enough to cause serious toxicity. The prescriber must\u2026<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-15443","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages\/15443","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=15443"}],"version-history":[{"count":0,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages\/15443\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=15443"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}