{"id":16130,"date":"2026-11-04T18:10:51","date_gmt":"2026-11-04T15:10:51","guid":{"rendered":"https:\/\/www.ortaakarsu.net\/?page_id=16130"},"modified":"2026-11-04T18:10:51","modified_gmt":"2026-11-04T15:10:51","slug":"english-interaction-klacid-mr-500-mg-tofacitinib","status":"publish","type":"page","link":"https:\/\/www.ortaakarsu.net\/?page_id=16130","title":{"rendered":"Clarithromycin (Klacid MR 500 mg) and Tofacitinib: interaction and safety"},"content":{"rendered":"<h2>Interaction mechanism<\/h2>\n<p>Systemic strong CYP3A4 inhibition can increase tofacitinib exposure.<\/p>\n<h2>Clinical significance and safety<\/h2>\n<p>Klacid MR 500 mg contains a systemic strong CYP3A4 inhibitor and can increase tofacitinib exposure and adverse-effect risk. The tofacitinib label recommends a prescriber-directed modification when used with strong CYP3A4 inhibitors. Confirm the full regimen with the prescriber or pharmacist before coadministration.<\/p>\n<h2>Using this information<\/h2>\n<p>This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Klacid MR 500 mg contains a systemic strong CYP3A4 inhibitor and can increase tofacitinib exposure and adverse-effect risk. The tofacitinib label recommends a prescriber-direc\u2026<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-16130","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages\/16130","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=16130"}],"version-history":[{"count":0,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages\/16130\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=16130"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}