{"id":16137,"date":"2026-11-04T18:10:52","date_gmt":"2026-11-04T15:10:52","guid":{"rendered":"https:\/\/www.ortaakarsu.net\/?page_id=16137"},"modified":"2026-11-04T18:10:52","modified_gmt":"2026-11-04T15:10:52","slug":"english-interaction-klamer-500-mg-oxycodone","status":"publish","type":"page","link":"https:\/\/www.ortaakarsu.net\/?page_id=16137","title":{"rendered":"Clarithromycin (Klamer 500 mg) and Oxycodone: interaction and safety"},"content":{"rendered":"<h2>Interaction mechanism<\/h2>\n<p>CYP3A4 inhibition can increase opioid exposure.<\/p>\n<h2>Clinical significance and safety<\/h2>\n<p>Clarithromycin can inhibit CYP3A-mediated metabolism and increase or prolong oxycodone effects, including potentially dangerous respiratory depression. The prescriber should review the combination and monitor for the effects described; do not adjust the opioid or the other medicine independently. Very slow breathing, inability to wake or collapse requires emergency help.<\/p>\n<h2>Using this information<\/h2>\n<p>This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Clarithromycin can inhibit CYP3A-mediated metabolism and increase or prolong oxycodone effects, including potentially dangerous respiratory depression. The prescriber should r\u2026<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-16137","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages\/16137","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=16137"}],"version-history":[{"count":0,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages\/16137\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=16137"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}