{"id":16255,"date":"2026-11-04T18:11:05","date_gmt":"2026-11-04T15:11:05","guid":{"rendered":"https:\/\/www.ortaakarsu.net\/?page_id=16255"},"modified":"2026-11-04T18:11:05","modified_gmt":"2026-11-04T15:11:05","slug":"english-interaction-macrol-500-mg-voclosporin","status":"publish","type":"page","link":"https:\/\/www.ortaakarsu.net\/?page_id=16255","title":{"rendered":"Clarithromycin (Macrol 500 mg) and Voclosporin: interaction and safety"},"content":{"rendered":"<h2>Interaction mechanism<\/h2>\n<p>Strong CYP3A4 inhibition markedly increases voclosporin exposure.<\/p>\n<h2>Clinical significance and safety<\/h2>\n<p>Macrol 500 mg contains a systemic strong CYP3A4 inhibitor. The voclosporin label contraindicates this combination because of increased exposure and toxicity, including kidney toxicity. The treating team should select a safe alternative without the patient independently interrupting either prescription.<\/p>\n<h2>Using this information<\/h2>\n<p>This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Macrol 500 mg contains a systemic strong CYP3A4 inhibitor. The voclosporin label contraindicates this combination because of increased exposure and toxicity, including kidney\u2026<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-16255","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages\/16255","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=16255"}],"version-history":[{"count":0,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages\/16255\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=16255"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}