{"id":17179,"date":"2026-11-04T18:12:14","date_gmt":"2026-11-04T15:12:14","guid":{"rendered":"https:\/\/www.ortaakarsu.net\/?page_id=17179"},"modified":"2026-11-04T18:12:14","modified_gmt":"2026-11-04T15:12:14","slug":"english-interaction-avanafil-riociguat","status":"publish","type":"page","link":"https:\/\/www.ortaakarsu.net\/?page_id=17179","title":{"rendered":"Avanafil and Riociguat: interaction and safety"},"content":{"rendered":"<h2>Interaction mechanism<\/h2>\n<p>A soluble-guanylate-cyclase stimulator and a PDE5 inhibitor can cause excessive blood-pressure lowering.<\/p>\n<h2>Clinical significance and safety<\/h2>\n<p>Avanafil and Riociguat: Riociguat and a PDE5 inhibitor must not be combined: the product information contraindicates concurrent use because of hypotension. Switching requires a specialist-controlled plan and an appropriate treatment-free interval. Do not combine or switch them yourself.<\/p>\n<h2>Using this information<\/h2>\n<p>This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Avanafil and Riociguat: Riociguat and a PDE5 inhibitor must not be combined: the product information contraindicates concurrent use because of hypotension. Switching requires\u2026<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-17179","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages\/17179","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17179"}],"version-history":[{"count":0,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages\/17179\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17179"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}