{"id":17375,"date":"2026-11-04T18:12:25","date_gmt":"2026-11-04T15:12:25","guid":{"rendered":"https:\/\/www.ortaakarsu.net\/?page_id=17375"},"modified":"2026-11-04T18:12:25","modified_gmt":"2026-11-04T15:12:25","slug":"english-interaction-evolocumab-inclisiran","status":"publish","type":"page","link":"https:\/\/www.ortaakarsu.net\/?page_id=17375","title":{"rendered":"Evolocumab and Inclisiran: interaction and safety"},"content":{"rendered":"<h2>Interaction mechanism<\/h2>\n<p>Inclisiran and PCSK9 antibodies act on the same LDL-lowering target by different mechanisms; this record concerns a planned switch.<\/p>\n<h2>Clinical significance and safety<\/h2>\n<p>Evolocumab and Inclisiran: A clinician may plan a switch from alirocumab or evolocumab to inclisiran, including timing of the last antibody and first inclisiran doses. This switching information does not recommend routine simultaneous use of two PCSK9-targeted treatments.<\/p>\n<h2>Using this information<\/h2>\n<p>This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Evolocumab and Inclisiran: A clinician may plan a switch from alirocumab or evolocumab to inclisiran, including timing of the last antibody and first inclisiran doses. This sw\u2026<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-17375","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages\/17375","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17375"}],"version-history":[{"count":0,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/pages\/17375\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17375"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}