{"id":11608,"date":"2026-10-26T19:59:29","date_gmt":"2026-10-26T16:59:29","guid":{"rendered":"https:\/\/www.ortaakarsu.net\/?p=11608"},"modified":"2026-10-26T19:59:29","modified_gmt":"2026-10-26T16:59:29","slug":"mesalazin-sulfasalazin-kolestiramin-etkilesimleri","status":"publish","type":"post","link":"https:\/\/www.ortaakarsu.net\/?p=11608","title":{"rendered":"Ba\u011f\u0131rsak Hastal\u0131klar\u0131nda Mesalazin, S\u00fclfasalazin ve Kolestiramin Etkile\u015fimleri"},"content":{"rendered":"<p><a href=\"https:\/\/www.ortaakarsu.net\/?ism_drug=pentasa-500-mg-uzatilmis-salimli-tablet\">Mesalazin (Pentasa)<\/a> ve <a href=\"https:\/\/www.ortaakarsu.net\/?ism_drug=salazopyrin-500-mg-enterik-tablet\">s\u00fclfasalazin (Salazopyrin)<\/a> ba\u011f\u0131rsak iltihab\u0131n\u0131n tedavisinde kullan\u0131labilir; <a href=\"https:\/\/www.ortaakarsu.net\/?ism_drug=resincolestiramina-4-g-oral-suspansiyon-icin-toz\">kolestiramin (Resincolestiramina)<\/a> ise ba\u011f\u0131rsak i\u00e7inde ba\u011flay\u0131c\u0131 etki g\u00f6sterir. Ayn\u0131 ki\u015fide ishal bulunmas\u0131 bu ila\u00e7lar\u0131n ayn\u0131 ama\u00e7la veya birbirinin yerine kullan\u0131labilece\u011fini g\u00f6stermez. Re\u00e7etenin amac\u0131, \u00fcr\u00fcn\u00fcn sal\u0131m bi\u00e7imi ve e\u015flik eden ila\u00e7lar birlikte de\u011ferlendirilmelidir.<\/p>\n<h2>Mesalazin: lokal etki, b\u00f6brek izlemini gereksiz k\u0131lmaz<\/h2>\n<p>Mesalazin kullan\u0131rken b\u00f6brek i\u015flevleri tedavi \u00f6ncesinde ve tedavi s\u0131ras\u0131nda kontrol edilir. <a href=\"https:\/\/www.ortaakarsu.net\/?ism_drug=voltaren-50-mg\">Diklofenak<\/a> gibi b\u00f6bre\u011fe zarar verebilen NSA\u0130\u0130 ila\u00e7lar riski art\u0131rabilir. <a href=\"https:\/\/www.ortaakarsu.net\/?ism_drug=imuran-50-mg\">Azatiyoprin<\/a>, 6-merkaptop\u00fcrin veya tioguaninle birlikte kullan\u0131mda kemik ili\u011fi bask\u0131lanmas\u0131 daha s\u0131k bildirilmi\u015ftir; beyaz kan h\u00fccresi izlemi \u00f6nemlidir. Bu birliktelik \u201chi\u00e7bir ko\u015fulda verilmez\u201d demek de\u011fildir: gerekli g\u00f6r\u00fcl\u00fcrse uzman taraf\u0131ndan laboratuvar plan\u0131yla y\u00f6netilir. <a href=\"https:\/\/www.medicines.org.uk\/emc\/product\/913\/smpc\" rel=\"noopener\">Kaynak: Pentasa, 4.4\u20134.5<\/a>.<\/p>\n<h2>S\u00fclfasalazinde hangi ila\u00e7lar\u0131 \u00f6zellikle s\u00f6ylemeliyim?<\/h2>\n<p>S\u00fclfasalazin azatiyoprinle birlikte l\u00f6kopeni ve kemik ili\u011fi bask\u0131lanmas\u0131 a\u00e7\u0131s\u0131ndan de\u011ferlendirilir. <a href=\"https:\/\/www.ortaakarsu.net\/?ism_drug=digoxin-berk-0-25-mg\">Digoksinin<\/a> emilimini azaltabilir. <a href=\"https:\/\/www.ortaakarsu.net\/?ism_drug=metoject-15-mg-enjektor\">Metotreksatla<\/a> kullan\u0131lan baz\u0131 hastalarda \u00f6zellikle bulant\u0131 gibi sindirim yak\u0131nmalar\u0131 artabilir. Ayr\u0131ca folik asidin emilim ve metabolizmas\u0131n\u0131 etkileyebilir; gebelik plan\u0131, kans\u0131zl\u0131k veya folat deste\u011fi konusu hekime bildirilmelidir. Takviyenin t\u00fcr\u00fc ve miktar\u0131 ki\u015fiye g\u00f6re belirlenir. <a href=\"https:\/\/www.medicines.org.uk\/emc\/product\/6686\/smpc\" rel=\"noopener\">Kaynak: Salazopyrin, 4.4\u20134.5<\/a>.<\/p>\n<h2>Kolestiraminle \u201cayn\u0131 anda almamak\u201d ne anlama gelir?<\/h2>\n<p>Kolestiramin kana \u00e7ok az ge\u00e7se de ba\u011f\u0131rsakta ba\u015fka a\u011f\u0131zdan ila\u00e7lar\u0131n emilimini azaltabilir. \u0130ncelenen \u00fcr\u00fcn bilgileri di\u011fer ila\u00e7lar\u0131n kolestiraminden en az bir saat \u00f6nce veya d\u00f6rt\u2013alt\u0131 saat sonra al\u0131nmas\u0131n\u0131 belirtir. Bu, herkes i\u00e7in haz\u0131r bir g\u00fcnl\u00fck \u00e7izelge de\u011fildir: \u00e7ok say\u0131da ila\u00e7 kullananlarda uygulanabilir saat plan\u0131n\u0131 eczac\u0131yla olu\u015fturun. \u00d6zellikle <a href=\"https:\/\/www.ortaakarsu.net\/?ism_drug=coumadin-5-mg\">varfarin<\/a>, digoksin ve <a href=\"https:\/\/www.ortaakarsu.net\/?ism_drug=levotiron-50-mcg\">levotiroksin<\/a> gibi ila\u00e7lar\u0131n ad\u0131n\u0131 belirtin. Kolestiramin eklenmesi kadar b\u0131rak\u0131lmas\u0131 da di\u011fer ilac\u0131n etkisini de\u011fi\u015ftirebilir. <a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=362ddd91-a63f-4ec6-841a-75785dd208c8\" rel=\"noopener\">Kaynak: Questran etiketi, etkile\u015fimler<\/a>.<\/p>\n<p>Toz kuru yutulmaz; \u00fcr\u00fcn\u00fcn kendi haz\u0131rlama talimat\u0131 izlenir. Kolestiramin kanl\u0131 veya iltihapl\u0131 ishalin kendi kendine tedavisi i\u00e7in kullan\u0131lmamal\u0131d\u0131r. <a href=\"https:\/\/www.medicines.org.uk\/emc\/product\/10589\/smpc\" rel=\"noopener\">Kaynak: Questran, 4.2<\/a>. Uzun kullan\u0131m ya\u011fda \u00e7\u00f6z\u00fcnen vitaminlerin emilimini etkileyebilir; ek vitamin gerekip gerekmedi\u011fi, \u00f6zellikle K vitamini ve p\u0131ht\u0131la\u015fma izlemiyle birlikte de\u011ferlendirilir.<\/p>\n<h2>Rifaksimin veya prednizolon da re\u00e7etede bulunuyorsa<\/h2>\n<p><a href=\"https:\/\/www.ortaakarsu.net\/?ism_drug=colidur-200-mg-film-tablet\">Rifaksimin<\/a> bir ba\u011f\u0131rsak antibiyoti\u011fidir; mesalazinin do\u011frudan e\u015fde\u011feri de\u011fildir. Kullan\u0131m nedenini ve di\u011fer ila\u00e7larla kontrol\u00fcn\u00fc <a href=\"https:\/\/www.ortaakarsu.net\/?p=11612\">antibiyotik ve antiparaziter ila\u00e7 rehberinde<\/a> ayr\u0131ca ele al\u0131yoruz. <a href=\"https:\/\/www.ortaakarsu.net\/?ism_drug=deltacortril-5-mg-tablet\">Prednizolon<\/a> eklenmi\u015fse bunun s\u00fcresi, izlem ve azaltma plan\u0131 re\u00e7eteyi yazan ekip\u00e7e belirlenir; uzun s\u00fcren tedavinin ani de\u011fi\u015ftirilmesi g\u00fcvenli bir yakla\u015f\u0131m de\u011fildir. <a href=\"https:\/\/assets.hpra.ie\/products\/Human\/24912\/Licence_PA1113-003-002_17062021113715.pdf\" rel=\"noopener\">Kaynak: prednizolon, 4.4<\/a>.<\/p>\n<h2>Rutin kontrolde sorulacaklar<\/h2>\n<ul>\n<li>Bu ila\u00e7 hangi hastal\u0131k veya ishal nedeni i\u00e7in verildi?<\/li>\n<li>Kan say\u0131m\u0131, karaci\u011fer ve b\u00f6brek testlerinin bir sonraki tarihi nedir?<\/li>\n<li>Kolestiraminle d\u00fczenli ila\u00e7lar\u0131m\u0131n saatlerini nas\u0131l yerle\u015ftirece\u011fiz?<\/li>\n<li>Gebelik plan\u0131m, folat veya vitamin takviyem tedaviyi etkiliyor mu?<\/li>\n<li>Tabletim enterik kapl\u0131 m\u0131, uzat\u0131lm\u0131\u015f sal\u0131ml\u0131 m\u0131; b\u00f6lme veya ezme konusunda kendi \u00fcr\u00fcn\u00fcm\u00fcn talimat\u0131 nedir?<\/li>\n<\/ul>\n<h2>Ne zaman h\u0131zl\u0131 de\u011ferlendirme gerekir?<\/h2>\n<p>S\u00fclfasalazin s\u0131ras\u0131nda ate\u015f, bo\u011faz a\u011fr\u0131s\u0131, a\u00e7\u0131klanamayan morarma veya sar\u0131l\u0131k geli\u015firse ayn\u0131 g\u00fcn sa\u011fl\u0131k ekibine ula\u015f\u0131n. Yayg\u0131n d\u00f6k\u00fcnt\u00fcyle a\u011f\u0131z\/g\u00f6z yaralar\u0131, nefes darl\u0131\u011f\u0131 veya ciddi genel durum bozulmas\u0131 acil de\u011ferlendirme gerektirir. Mesalazin s\u0131ras\u0131nda belirgin yeni g\u00f6\u011f\u00fcs a\u011fr\u0131s\u0131, idrar azalmas\u0131 veya \u015fiddetli ba\u015f a\u011fr\u0131s\u0131na g\u00f6rme de\u011fi\u015fikli\u011fi e\u015flik etmesi de bekletilmemelidir. Her yeni kar\u0131n a\u011fr\u0131s\u0131n\u0131 otomatik olarak hastal\u0131k ata\u011f\u0131 kabul etmeyin.<\/p>\n<p>\u0130lgili okumalar: <a href=\"https:\/\/www.ortaakarsu.net\/?p=11490\">levotiroksin ve emilim<\/a>; <a href=\"https:\/\/www.ortaakarsu.net\/?p=11465\">kan suland\u0131r\u0131c\u0131yla a\u011fr\u0131 kesici<\/a>.<\/p>\n<hr>\n<p><strong>Kaynak kontrol\u00fc:<\/strong> <time datetime=\"2026-10-26\">26 Ekim 2026<\/time>. Bu i\u00e7erik yapay zek\u00e2 destekli bir kaynak \u00f6zetidir; hekim veya eczac\u0131 taraf\u0131ndan klinik inceleme yap\u0131ld\u0131\u011f\u0131 anlam\u0131na gelmez. Ki\u015fisel tedavi plan\u0131 de\u011fildir. Yabanc\u0131 \u00fcr\u00fcn belgelerindeki etken madde riskleri, T\u00fcrkiye&#8217;deki \u00fcr\u00fcn\u00fcn g\u00fcncel K\u00dcB ve kullanma talimat\u0131yla birlikte de\u011ferlendirilmelidir.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mesalazin ve s\u00fclfasalazinde kan-b\u00f6brek izlemi; kolestiraminle di\u011fer ila\u00e7lar\u0131n emilimi, zaman plan\u0131 ve hekime bildirilmesi gereken belirtiler.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-11608","post","type-post","status-publish","format-standard","hentry","category-genel"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/11608","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11608"}],"version-history":[{"count":1,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/11608\/revisions"}],"predecessor-version":[{"id":11617,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/11608\/revisions\/11617"}],"wp:attachment":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11608"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11608"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11608"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}