{"id":6628,"date":"2020-08-12T17:25:33","date_gmt":"2020-08-12T14:25:33","guid":{"rendered":"https:\/\/www.ortaakarsu.net\/?p=6628"},"modified":"2025-04-20T17:17:52","modified_gmt":"2025-04-20T14:17:52","slug":"favicovir","status":"publish","type":"post","link":"https:\/\/www.ortaakarsu.net\/?p=6628","title":{"rendered":"Favicovir Yan Etkileri ve Favicovir Kullananlar"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Favicovir Yan Etkiler<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Favicovir kullananlarda en s\u0131k g\u00f6r\u00fclen yan etkiler: ishal(diyare), serum \u00fcrik asit seviyesinde belirgin art\u0131\u015f, serum transaminaz (ALT, AST, ALP) ve total bilirubin d\u00fczeylerinde y\u00fckselme ve n\u00f6trofil d\u00fczeyinde azalma g\u00f6zlenmektedir. Sindirim sisteminde g\u00f6zlenen yan etkileri bulant\u0131, gaz art\u0131\u015f\u0131.<\/strong> \u00c7ok s\u0131k g\u00f6r\u00fclen yan etkiler i\u00e7erisinde<strong> ishal <\/strong>\u00f6zellikle yayg\u0131n bir yan etki olarak g\u00f6ze \u00e7arp\u0131yor. Favicovir kullananlar bu a\u00e7\u0131klamay\u0131 yapmaktad\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Hamilelikte kullan\u0131lmamas\u0131 gerekir<\/strong>; <strong>teratojeniktir. S\u00fcte ge\u00e7er.<\/strong> T\u00fcm bu yan etkiler ciddi gibi g\u00f6r\u00fcnmese de her ila\u00e7ta oldu\u011fu gibi bu ila\u00e7ta da <strong>a\u015f\u0131r\u0131 reaksiyon \u015fans\u0131 vard\u0131r<\/strong>. <strong>Bu durumda doktorunuza bilgi veriniz.<\/strong> Bu durum d\u00fc\u015f\u00fck olas\u0131l\u0131kl\u0131 olsa da ak\u0131lda bulundurulmal\u0131d\u0131r. Yan etkiler ila\u00e7lar\u0131n en b\u00fcy\u00fck dezavantajlar\u0131d\u0131r. <a href=\"https:\/\/www.ortaakarsu.net\/?p=6671\">Koronavir\u00fcs \u0130la\u00e7 Geli\u015ftirme \u00c7al\u0131\u015fmalar\u0131<\/a> adl\u0131 yaz\u0131da<strong> favicovir yan etkileri<\/strong> ba\u015fta olmak \u00fczere di\u011fer ila\u00e7lar ve geli\u015ftirilme y\u00f6ntemleri hakk\u0131nda da bilgiler bulunmakta. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Favicovir ve Delta Varyant\u0131na Etkisi<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Favicovir, yani favipiravir daha bula\u015f\u0131c\u0131 ve \u00f6l\u00fcmc\u00fcl oldu\u011fu belirlenen Delta Varyant\u0131na kar\u015f\u0131 etkili mi? \u015eu an elimizdeki bilgilere bakarak etkili oldu\u011fu s\u00f6ylenebilir ancak Delta Varyant\u0131n\u0131n Covid-19 hastal\u0131\u011f\u0131n\u0131n daha a\u011f\u0131r bir versiyonu oldu\u011funu bir ger\u00e7ek. Hindistan&#8217;dan yay\u0131lmaya ba\u015flayan Delta Varyant\u0131 d\u00fcnyan\u0131n \u00e7e\u015fitli yerlerinde g\u00f6r\u00fclmekte ve yay\u0131lmakta. A\u015f\u0131lar\u0131n elimizdeki en \u00f6nemli silah oldu\u011fu ger\u00e7e\u011fi ise a\u015f\u0131lar\u0131n Delta Varyant\u0131n\u0131 daha hafif ge\u00e7irmemizi sa\u011flad\u0131\u011f\u0131 bir ger\u00e7ek. Favicovir ise hastal\u0131\u011f\u0131n daha da hafif ge\u00e7irilmesini sa\u011flamada etkili olabilir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Delta Varyant\u0131n\u0131n Covid-19&#8217;un diken protein yap\u0131s\u0131 olarak bilinen AC2 resept\u00f6r\u00fcne tutunmas\u0131n\u0131 sa\u011flayan k\u0131sm\u0131nda mutasyon oldu\u011fu biliniyor. Bu mutasyon Delta Varyant\u0131n\u0131n AC2 resept\u00f6r\u00fcne tutunmas\u0131n\u0131 kolayla\u015ft\u0131rarak bula\u015f oran\u0131n\u0131 artt\u0131r\u0131yor.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/www.ortaakarsu.net\/?p=7612\"><img decoding=\"async\" width=\"527\" height=\"251\" src=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/image-70.png\" alt=\"\" class=\"wp-image-7621\" srcset=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/image-70-300x143.png 300w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/image-70-500x238.png 500w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/image-70.png 527w\" sizes=\"(max-width: 527px) 100vw, 527px\" \/><\/a><figcaption>Covid-19&#8217;a etkili ba\u015fka bir ila\u00e7 i\u00e7in resme t\u0131klay\u0131n\u0131z<\/figcaption><\/figure>\n<\/div>\n\n\n<script async=\"\" src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-7050495227290123\" crossorigin=\"anonymous\"><\/script>\n<!-- Yatay_G\u00f6rnt\u00fcl\u00fc -->\n<ins class=\"adsbygoogle\" style=\"display:block\" data-ad-client=\"ca-pub-7050495227290123\" data-ad-slot=\"6780495801\" data-ad-format=\"auto\" data-full-width-responsive=\"true\"><\/ins>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script>\n\n\n\n<h2 class=\"wp-block-heading\">Favicovir, Covid Tedavisinde Kullan\u0131m\u0131 ve Favicovir Yan Etkileri<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Favipiravir, \u00c7in\u2019de 15 \u015eubat 2020\u2019de yeni grip tedavisi i\u00e7in onaylanm\u0131\u015f olmakla birlikte COVID-19 tedavisinde klinik denemeleri devam etmektedir.  <strong>Favipiravir yeni bir RNA\u2019ya ba\u011fl\u0131 RNA polimeraz (RdRp) inhibit\u00f6r\u00fc t\u00fcr\u00fcd\u00fcr<\/strong>. <strong>Anti-influenza vir\u00fcs aktivitesine ek olarak, favipiravir, flavi-, alfa-, filo-,  bunya-, arena-, noro- ve di\u011fer RNA vir\u00fcslerinin replikasyonunu bloke edebilir<\/strong>.  <strong>Favipiravir, h\u00fccrelerde aktif bir fosforile forma d\u00f6n\u00fc\u015ft\u00fcr\u00fcl\u00fcr ve viral RNA polimeraz taraf\u0131ndan bir substrat olarak tan\u0131n\u0131r, b\u00f6ylece RNA polimeraz  aktivitesini inhibe eder<\/strong>. Bu nedenle, favipiravir bir RNA vir\u00fcs\u00fc olan SARS-CoV-2 \u00fczerinde potansiyel antiviral etkiye sahip olabilece\u011fi  d\u00fc\u015f\u00fcn\u00fclm\u00fc\u015ft\u00fcr. Yaz\u0131n\u0131n bu b\u00f6l\u00fcm\u00fcnde akademik kaynaklardan ve Sa\u011fl\u0131k bakanl\u0131\u011f\u0131 Covid-19 tedavi rehberinde a\u00e7\u0131klanan favicovir yan etkiler ile ilgili de ayr\u0131nt\u0131l\u0131 bilgiler bulunmaktad\u0131r. \u00d6ncelikle bu ilac\u0131n nas\u0131l bir mekanizma ile \u00e7al\u0131\u015ft\u0131\u011f\u0131na ve etkisi hakk\u0131nda akademik kaynaklardan elde edilen bilgilere bakal\u0131m.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">Favicovir Yan Etkileri Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131ndan Favicovir A\u00e7\u0131klamas\u0131 <\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">Corona Vir\u00fcs&#8217;e kar\u015f\u0131 yerli ila\u00e7 <strong>Favicovir milli imkanlarla sentezlendi<\/strong>. \u0130la\u00e7 ilk olarak <strong>favipiravir ad\u0131yla Japon bir kimya \u015firketi taraf\u0131ndan RNA vir\u00fcslerine kar\u015f\u0131 sentezlendi<\/strong>. <strong>\u015euan ise bu ilac\u0131n sentezi milli imkanlarla yap\u0131lmakta ve T\u00fcrkiye&#8217;de favicovir \u00fcretilmekte.<\/strong> Bat\u0131 Nil ve Sar\u0131 humma vir\u00fcslerinin tedavisinde kullan\u0131lmaktad\u0131r. <strong>Flavivir\u00fcsler, arenavir\u00fcsler gibi pek \u00e7ok vir\u00fcse kar\u015f\u0131 da etkinlik g\u00f6stermektedir.<\/strong> \u00c7in&#8217;den yap\u0131lan a\u00e7\u0131klamada Vuhan ve Shenzhen&#8217;deki vakalarda etkili oldu\u011fu s\u00f6ylenmi\u015ftir. Yine \u00c7in&#8217;den yap\u0131lan a\u00e7\u0131klamada hastal\u0131\u011f\u0131n hafif seyrett\u011fi ki\u015filerde iyile\u015fme h\u0131z\u0131n\u0131 artt\u0131rd\u0131\u011f\u0131 belirtilmi\u015ftir. \u0130lac\u0131n on bir g\u00fcn olan tedavi s\u00fcresini d\u00f6rt g\u00fcne d\u00fc\u015f\u00fcrd\u00fc\u011f\u00fc g\u00f6zlenmi\u015ftir. <strong>Favicovir kullananlar<\/strong> ilac\u0131n kullan\u0131m\u0131 ve dozaj\u0131n\u0131 her zaman sa\u011fl\u0131k personelinin tavsiye etti\u011fi gibi kullanmal\u0131d\u0131r. Bu konuda <strong>sa\u011fl\u0131k bakanl\u0131\u011f\u0131n\u0131n yay\u0131nlad\u0131\u011f\u0131 tedavi rehberi  T\u00fcrkiye i\u00e7in en \u00f6nemli kaynak ve rehberdir<\/strong>. Bu yaz\u0131n\u0131n devam\u0131nda da bu rehber payla\u015f\u0131lm\u0131\u015f ve bilgiler ayr\u0131nt\u0131s\u0131yla incelenmi\u015ftir.<\/p>\n\n\n<div class=\"wp-block-image is-style-default\">\n<figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/favicovir.png\" alt=\"Favicovir molek\u00fcl\u00fcn\u00fcn yap\u0131s\u0131\" class=\"wp-image-6656\" width=\"341\" height=\"234\"\/><figcaption>Favicovir Molek\u00fcl\u00fc <\/figcaption><\/figure>\n<\/div>\n\n\n<script async=\"\" src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\n<!-- Yatay_G\u00f6rnt\u00fcl\u00fc -->\n<ins class=\"adsbygoogle\" style=\"display:block\" data-ad-client=\"ca-pub-7050495227290123\" data-ad-slot=\"6780495801\" data-ad-format=\"auto\" data-full-width-responsive=\"true\"><\/ins>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Favicovir de etki mekanizmas\u0131<\/strong> olarak di\u011fer ila\u00e7lar\u0131n etki mekanizmas\u0131na benzer \u00f6zellikler g\u00f6stermektedir. Vir\u00fcslere veya di\u011fer b\u00fct\u00fcn hastal\u0131klara kar\u015f\u0131 kullan\u0131lan ila\u00e7lar\u0131n b\u00fcy\u00fck bir b\u00f6l\u00fcm\u00fc, hastal\u0131kla ilgili belirli enzim veya resept\u00f6rlerin inhibe edilmesi, yani engellenmesi ile \u00e7al\u0131\u015f\u0131r. Bir inhibisyon mekanizmas\u0131n\u0131n nas\u0131l i\u015fledi\u011fini anlamak i\u00e7in <a href=\"https:\/\/www.ortaakarsu.net\/?p=6446\">Enzim \u0130nhibit\u00f6r\u00fc ve \u0130nhibisyon \u00c7e\u015fitleri<\/a> adl\u0131 yaz\u0131y\u0131 okuyabilirsiniz. Bir <strong>enzim inhibisyonu<\/strong> ile ilgili in vitro \u00e7al\u0131\u015fmalar\u0131n nas\u0131l yap\u0131ld\u0131\u011f\u0131n\u0131 ve verilerin nas\u0131l de\u011ferlendirildi\u011fini \u00f6\u011frenmek i\u00e7in de <a href=\"https:\/\/www.ortaakarsu.net\/?p=95\">Glutatyon Red\u00fcktaz Enzim Aktivitesi<\/a> yaz\u0131s\u0131n\u0131 okuman\u0131z ila\u00e7lar\u0131n genel itibari ile nas\u0131l \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131n anla\u015f\u0131lmas\u0131n\u0131 sa\u011flayacakt\u0131r. <strong>Favicovir<\/strong> de benzer \u015fekilde RNA vir\u00fcslerine etki eden bir ila\u00e7 etken maddesidir. Favicovir etki mekanizmas\u0131na <a href=\"https:\/\/www.ortaakarsu.net\/?p=7124\">Favipiravir Nedir? Favipiravir Yan Etkileri Nelerdir?<\/a> adl\u0131 yaz\u0131da daha ayr\u0131nt\u0131l\u0131 de\u011finilmektedir.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131ndan Favicovir ve Favipiravir A\u00e7\u0131klamas\u0131<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131n\u0131n Yay\u0131nlad\u0131\u011f\u0131 rehberde hem \u201cAyakta tedavi g\u00f6recek a\u011f\u0131r olmayan veya hafif-orta pn\u00f6monisi olabilecek\/kesin tan\u0131 konulmu\u015f Covid-19 hastalar\u0131nda\u201d hem de \u201cHastaneye yat\u0131\u015f endikasyonu olan Covid-19 hastalar\u0131nda\u201d Hidroksiklorokin ve\/veya Favipiravir(favicovir) kullan\u0131m\u0131 \u00f6neriliyor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bu iki ila\u00e7 i\u00e7in de mutlaka hekim tavsiyesi al\u0131nmas\u0131 gerekiyor ve devlet hastanelerinin bas\u0131lar\u0131nda Covid-19 ila\u00e7 merkezleri kurulmu\u015f durumda. Hastalar ila\u00e7lar\u0131n\u0131 bu birimlerden temin edebiliyor.  Erken tan\u0131 ve tedaviye ba\u015flanmas\u0131 ile Favicovir ve\/veya hidroksiklorokin ila\u00e7lar\u0131na ba\u015flanmas\u0131 hastaneye yat\u0131\u015f ve hastal\u0131\u011f\u0131n a\u011f\u0131r seyretmesi b\u00fcy\u00fck \u00f6l\u00e7\u00fcde engelleniyor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131n\u0131n yay\u0131nlad\u0131\u011f\u0131 bro\u015f\u00fcrde ila\u00e7lar\u0131n kullan\u0131m zaman\u0131, dikkat edilmesi gereken hususlar ve ila\u00e7lar\u0131n kullan\u0131lmamas\u0131 gereken durumlara dikkat \u00e7ekiliyor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kaynak: <a href=\"https:\/\/covid19.saglik.gov.tr\/Eklenti\/37219\/0\/favipiravir-200-mg-tablet--guncelleme-tarihi-14042020pdf.pdf\">Favicovir 200 mg Kullan\u0131m\u0131<\/a><\/p>\n\n\n\n<script async=\"\" src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\n<!-- Yatay_G\u00f6rnt\u00fcl\u00fc -->\n<ins class=\"adsbygoogle\" style=\"display:block\" data-ad-client=\"ca-pub-7050495227290123\" data-ad-slot=\"6780495801\" data-ad-format=\"auto\" data-full-width-responsive=\"true\"><\/ins>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script>\n\n\n\n<h3 class=\"wp-block-heading\">COVID-19 Bula\u015fma S\u00fcreci ve \u00d6nlemler<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Covid-19 hastal\u0131\u011f\u0131n\u0131n bula\u015fma s\u00fcreci<\/strong>nin incelendi\u011fi videoda bu s\u00fcreci ve &#8220;<strong>maske, mesafe, hijyen<\/strong>&#8221; politikas\u0131n\u0131n ne kadar do\u011fru oldu\u011funu g\u00f6rebiliriz. Covid-19 tedavisinde kullan\u0131lan bir di\u011fer ila\u00e7 olan <strong>Plaquenil yan etkilerini<\/strong> \u00f6\u011frenmek i\u00e7in <a href=\"https:\/\/www.ortaakarsu.net\/?p=7196\">Plaquenil Yan Etkileri Nelerdir?<\/a> adl\u0131 yaz\u0131y\u0131 okuyabilirsiniz.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.ortaakarsu.net\/wp-admin\/edit.php?post_type=post\"><\/a><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"video-shortcode\"><iframe title=\"3D Animation: SARS-CoV-2 virus transmission leading to COVID-19\" width=\"1200\" height=\"675\" src=\"https:\/\/www.youtube.com\/embed\/PSnSo9kYlH4?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">COV\u0130D-19 Mutasyona U\u011frar m\u0131? Favicovir&#8217;in Etkisi Nedir?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Covid-19 vir\u00fcs\u00fc<\/strong> her canl\u0131 gibi <strong>mutasyona u\u011framaktad\u0131r<\/strong>. Her canl\u0131n\u0131n DNA ve RNA yap\u0131s\u0131nda zamana ba\u011fl\u0131 olarak bir tak\u0131m de\u011fi\u015fiklikler her zaman ger\u00e7ekle\u015fmektedir. Bu son derece s\u0131radan bir durumdur. Ancak s\u00f6z konusu olan, \u00f6nlem al\u0131nmak i\u00e7in canla ba\u015fla \u00e7al\u0131\u015f\u0131lan ve daha da \u00f6nemlisi a\u015f\u0131 geli\u015ftirmek i\u00e7in b\u00fcy\u00fck kaynak, zaman ve irade harcanan bir hastal\u0131ksa durum tehlikeli olabilmektedir. \u00c7\u00fcnk\u00fc kesin olmamak ile beraber ke\u015ffi yap\u0131lan a\u015f\u0131, mutasyona u\u011frayan bir vir\u00fcse etki etmeyebilir. Bu senaryo en korkulan senaryodur. B\u00f6yle bir durumda <strong>favicovir<\/strong> gibi covid-19 i\u00e7in <strong>ba\u015far\u0131 ile kullan\u0131lan ila\u00e7lar\u0131n etkilerini yok edebilir<\/strong>. Ayr\u0131nt\u0131l\u0131 bilgi i\u00e7in <strong>a\u015fa\u011f\u0131daki videoya t\u0131klayabilirsiniz<\/strong>.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"video-shortcode\"><iframe title=\"Mutasyon nedir? Koronavir\u00fcs mutasyon ge\u00e7irirse ne olur?\" width=\"1200\" height=\"675\" src=\"https:\/\/www.youtube.com\/embed\/8EvVSXUF-3U?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<script async=\"\" src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\n<!-- Yatay_G\u00f6rnt\u00fcl\u00fc -->\n<ins class=\"adsbygoogle\" style=\"display:block\" data-ad-client=\"ca-pub-7050495227290123\" data-ad-slot=\"6780495801\" data-ad-format=\"auto\" data-full-width-responsive=\"true\"><\/ins>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script>\n\n\n\n<p class=\"wp-block-paragraph\">Vir\u00fcs\u00fcn mutasyona u\u011framas\u0131 durumda t\u0131pk\u0131 di\u011fer hastal\u0131klarda yap\u0131ld\u0131\u011f\u0131 gibi ila\u00e7 ke\u015fif \u00e7al\u0131\u015fmalar\u0131 yeniden ba\u015flan\u0131r. Bu da geli\u015ftirilen ila\u00e7lar\u0131n ve a\u015f\u0131lar\u0131n \u00e7\u00f6pe at\u0131lmas\u0131 anlam\u0131na gelir. Parazit organizmalar i\u00e7in ila\u00e7 ke\u015fif \u00e7al\u0131\u015fmalar\u0131 ile ilgili bir \u00f6rnek i\u00e7in <a href=\"https:\/\/www.ortaakarsu.net\/?p=7039\">Antimalaryal \u0130la\u00e7lar \u2013 Yap\u0131 Bazl\u0131 \u0130la\u00e7 Tasar\u0131m\u0131<\/a> adl\u0131 \u00e7al\u0131\u015fma <strong>favicovir gibi ila\u00e7lar\u0131n en ba\u015ftan tasarlanmas\u0131<\/strong> anlam\u0131na gelebilir. Ancak unutulmamal\u0131d\u0131r ki <strong>vir\u00fcs\u00fcn mutasyona u\u011framas\u0131 kesin de\u011fildir<\/strong>. Sadece ihtimal dahilindedir. <strong>Favicovir yan etkileri<\/strong> bak\u0131m\u0131ndan d\u00fc\u015f\u00fcn\u00fcld\u00fc\u011f\u00fcnde normal d\u00fczeyde yan etkile sahiptir. Ancak yeni geli\u015ftirilecek her hangi bir ila\u00e7ta <strong>favicovir yan etkileri<\/strong> haricinde ba\u015fka yan etkiler geli\u015fmesi de s\u00f6z konusudur.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Favicovir\/Favipiravir D\u00fcnya Genelinde Kullan\u0131l\u0131yor.<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Fujifilm, COVID-19 i\u00e7in olas\u0131 bir tedavi olarak test edilen bir\u00e7ok onayl\u0131 ila\u00e7tan biri olan antiviral tedavisi <a href=\"https:\/\/www.ortaakarsu.net\/?p=7124\">favipiravir<\/a>&#8216;in \u00fcretimini art\u0131r\u0131yor. Japonya&#8217;da Faz III klinik denemeleri devam ediyor ve h\u00fck\u00fcmet 2 milyon tedavi kursu sipari\u015f etti. ABD&#8217;de, Fujifilm bu ay\u0131n ba\u015flar\u0131nda Faz II denemelerine ba\u015flad\u0131. Fujifilm&#8217;in Avigan markas\u0131 alt\u0131nda satt\u0131\u011f\u0131 Favipiravir, 2014 y\u0131l\u0131ndan beri Japonya&#8217;da grip ve di\u011fer ila\u00e7lara yan\u0131t vermeyen di\u011fer viral su\u015flar\u0131 tedavi etmek i\u00e7in onayland\u0131. Bir Fujifilm s\u00f6zc\u00fcs\u00fc, \u015firketin hen\u00fcz etkinlik kan\u0131t\u0131 sunmamas\u0131na ra\u011fmen, &#8220;Avigan tabletlerinin, karakteristik etki mekanizmas\u0131 g\u00f6z \u00f6n\u00fcne al\u0131nd\u0131\u011f\u0131nda yeni koronavir\u00fcs ile enfeksiyona kar\u015f\u0131 etkinli\u011fe sahip olmas\u0131 bekleniyor&#8221; dedi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Japon h\u00fck\u00fcmeti, Avigan&#8217;\u0131n Japonya&#8217;da yerel olarak \u00fcretilen malzemeler kullan\u0131larak yap\u0131lmas\u0131n\u0131 tercih etti\u011fini belirtti. Avigan&#8217;\u0131 geli\u015ftiren Fujifilm&#8217;in yan kurulu\u015fu Toyama Chemical, kimyasal \u00fcreticisi Denka&#8217;dan \u00f6nemli bir ara \u00fcr\u00fcn olan dietil malonat ihtiyac\u0131n\u0131n bir k\u0131sm\u0131n\u0131 kar\u015f\u0131layacak. Firma, Niigata Eyaletinde, malzemenin k\u00fcresel a\u015f\u0131r\u0131 tedariki nedeniyle 2017&#8217;de kapatt\u0131\u011f\u0131 bir fabrikay\u0131 yeniden ba\u015flatacak. Bir Denka s\u00f6zc\u00fcs\u00fcne g\u00f6re, tesis s\u00f6k\u00fclmedi ve May\u0131s ay\u0131 sonlar\u0131nda tam faaliyetlerine devam edebilecek. <strong>Favicovir yan etkileri i\u00e7in ilk testleri de dolay\u0131s\u0131yla Japonya yapm\u0131\u015ft\u0131r<\/strong>. <\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Favicovir\/Favipiravir Faz II ve Faz III Testleri Yap\u0131l\u0131yor<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Fujifilm, Wako Pure Chemical yan kurulu\u015funda ara \u00fcr\u00fcn \u00fcretimini art\u0131racak ve di\u011fer hammadde tedarik\u00e7ileriyle ortakl\u0131klar kuracak. Fujifilm, Haziran ay\u0131nda Japonya&#8217;da 100 ki\u015fiyi kapsayan k\u00fc\u00e7\u00fck Faz III denemelerini tamamlamay\u0131 bekliyor. <strong>ABD&#8217;de, 50 ki\u015filik Faz II denemeleri Brigham and Women\u2019s Hospital, Massachusetts General Hospital ve University of Massachusetts Medical School&#8217;da y\u00fcr\u00fct\u00fclecektir. \u0130talya ve \u00c7in, antiviralin klinik denemelerini Mart ay\u0131nda ba\u015flatt\u0131. Fujifilm s\u00f6zc\u00fcs\u00fcne g\u00f6re, \u015fimdiye kadarki insan denemeleri herhangi bir olumsuz reaksiyonu ortaya \u00e7\u0131karmad\u0131.<\/strong> Bununla birlikte, <strong>ila\u00e7 hamile kad\u0131nlar \u00fczerinde test edilmemi\u015ftir, \u00e7\u00fcnk\u00fc klinik \u00f6ncesi \u00e7al\u0131\u015fmalar fet\u00fcslere olas\u0131 zararlar\u0131 g\u00f6stermi\u015ftir<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">COVID-19&#8217;a kar\u015f\u0131 test edilen ba\u015fka bir antiviral olan Gilead Sciences&#8217;\u0131n remdesivir&#8217;i gibi, <strong>favipiravir<\/strong>, viral replikasyonda rol oynayan RNA polimeraz\u0131n se\u00e7ici bir inhibit\u00f6r\u00fcd\u00fcr. Fujifilm, hayvan \u00e7al\u0131\u015fmalar\u0131, <strong>grip ve Bat\u0131 Nil vir\u00fcs\u00fc, sar\u0131 humma, \u015fap hastal\u0131\u011f\u0131 ve di\u011fer vir\u00fcslere kar\u015f\u0131 etkili oldu\u011funu g\u00f6sterdi<\/strong>. Firma, \u015fimdiye kadar Japon h\u00fck\u00fcmetinin <strong>COVID-19<\/strong>&#8216;a kar\u015f\u0131 kullanmak \u00fczere b\u00fcy\u00fck miktarlarda <strong>favipiravir<\/strong> sipari\u015f eden tek grup oldu\u011funu belirtiyor. D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc, \u00e7ok uluslu bir denemede hastal\u0131\u011fa kar\u015f\u0131 test etti\u011fi mevcut d\u00f6rt ila\u00e7 aras\u0131nda favipiraviri dahil etmedi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kaynak: <a href=\"https:\/\/cen.acs.org\/pharmaceuticals\/drug-development\/Fujifilm-tests-favipiravir-COVID-19\/98\/i15\">American Chemical Society<\/a><\/p>\n\n\n\n<script async=\"\" src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\n<!-- Yatay_G\u00f6rnt\u00fcl\u00fc -->\n<ins class=\"adsbygoogle\" style=\"display:block\" data-ad-client=\"ca-pub-7050495227290123\" data-ad-slot=\"6780495801\" data-ad-format=\"auto\" data-full-width-responsive=\"true\"><\/ins>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script>\n\n\n\n<h2 class=\"wp-block-heading\">Covid-19 A\u015f\u0131s\u0131, %90 Etkili A\u015f\u0131<\/h2>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"video-shortcode\"><iframe title=\"Pfizer Biontech Covid-19 a\u015f\u0131s\u0131 &#039;y\u00fczde 90 ba\u015far\u0131l\u0131&#039;\" width=\"1200\" height=\"675\" src=\"https:\/\/www.youtube.com\/embed\/4B0zvzNIEqg?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><figcaption>%90 Etkili A\u015f\u0131 i\u00e7in T\u00fcrkiye Cumhuriyeti Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 ile G\u00f6r\u00fc\u015fmelerin Yap\u0131ld\u0131\u011f\u0131 \u0130fade Ediliyor<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Ge\u00e7ti\u011fimiz g\u00fcnlerde kayda de\u011fer ilk ba\u015far\u0131l\u0131 a\u015f\u0131 \u00e7al\u0131\u015fmas\u0131 <strong>Pfizer<\/strong> ve <strong>BioNTech<\/strong> ortak \u00e7al\u0131\u015fmas\u0131 ile geli\u015ftirilen a\u015f\u0131 oldu. BioNTeck&#8217;in ba\u015f\u0131nda Almanya&#8217;ya g\u00f6\u00e7 eden T\u00fcrk ailelerin \u00e7ocuklar\u0131 olan bir kar\u0131-koca bulunmakta. A\u015f\u0131n\u0131n ba\u015far\u0131l\u0131 oldu\u011funu da a\u00e7\u0131klayan onlar. Plasebo etkili <strong>Faz 3 deneylerinde<\/strong> g\u00f6r\u00fclen <strong>%90 ba\u015far\u0131<\/strong> sonu\u00e7lar al\u0131nm\u0131\u015f. Bu hi\u00e7 \u015f\u00fcphesiz \u00fcmit verici bir haber ancak \u00e7al\u0131\u015fma \u00e7ok yeni ve \u015fuan(yaz\u0131n\u0131n yaz\u0131ld\u0131\u011f\u0131 tarih 13 Kas\u0131m 2020) ba\u011f\u0131ms\u0131z hakemlere sahip bilimsel dergilerde yay\u0131nlanm\u0131\u015f bir \u00e7al\u0131\u015fma yok. Bu hi\u00e7 \u015f\u00fcphesiz a\u015f\u0131n\u0131n hemen kullan\u0131lmas\u0131n\u0131n istenmesinden kaynakl\u0131, &#8220;\u00e7al\u0131\u015fan a\u015f\u0131&#8221; ihtiyac\u0131n\u0131n \u00e7ok acil uygulamaya ge\u00e7ilme ihtiyac\u0131ndan kaynakl\u0131 bir durum.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sa\u011fl\u0131k bakanl\u0131\u011f\u0131<\/strong> ile a\u015f\u0131 hakk\u0131nda g\u00f6r\u00fc\u015ft\u00fcklerini ifade eden BioNTeck&#8217;in CEO&#8217;su \u00f6n\u00fcm\u00fczdeki bir ka\u00e7 ay\u0131 hedef g\u00f6sterdi. Ocak, \u015eubat veya Mart aylar\u0131 i\u00e7in umutlu konu\u015fmalar ge\u00e7se de bu s\u00fcreye kadar Favicovir gibi ila\u00e7lar\u0131n kullan\u0131m\u0131na devam edilece\u011fi g\u00f6r\u00fcn\u00fcyor. Favicovir yan etkileri bak\u0131m\u0131ndan g\u00f6stermi\u015f oldu\u011fu semptonlar neticesinde hala g\u00fcncel olarak akademik \u00e7al\u0131\u015fmalar\u0131n bir konu olmaya devam ediyor. %90 etkili olan a\u015f\u0131n\u0131n tam olarak kitlesel boyutta uygulanmaya ba\u015flama tarihi hakk\u0131nda \u015fuan net bir bilgi yok.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Favicovir yani favipiravir nas\u0131l etki eder sorusuna ise favicovirin etki mekanizmas\u0131 ayd\u0131nlat\u0131larak cevap verilmi\u015f durumda. Bu yaz\u0131ya ula\u015fmak i\u00e7in <a href=\"https:\/\/www.ortaakarsu.net\/?p=7283\">favicovir nas\u0131l etki eder?<\/a> yaz\u0131s\u0131n\u0131 okuyabilirsiniz.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">A\u015f\u0131lar\u0131n Birbirinden Fark\u0131<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Ayn\u0131 anda piyasaya \u00e7\u0131kmaya haz\u0131rlanan pek \u00e7ok a\u015f\u0131n\u0131n hem fiyat hem de yan etkileri bak\u0131m\u0131ndan pek \u00e7ok fark\u0131 var. Bu farklar hi\u00e7 \u015f\u00fcphesiz \u00fclkelerin a\u015f\u0131lar\u0131 tercih etme fakt\u00f6rlerini etkileyecek. \u00d6zellikle son teknoloji \u00fcr\u00fcn\u00fc olarak BioNTeck a\u015f\u0131s\u0131 son derece pahal\u0131. \u00c7in a\u015f\u0131s\u0131 ile ilgili ise her hangi bir veri zaten payla\u015f\u0131lm\u0131yor ve \u00c7in h\u00fck\u00fcmetinin yay\u0131nlad\u0131\u011f\u0131 verilerin do\u011frulamas\u0131n\u0131n yap\u0131lmas\u0131 pek m\u00fcmk\u00fcn de\u011fil. A\u015f\u0131lar hakk\u0131nda hada fazla bilgi almak i\u00e7in a\u015f\u0131lar ile ilgili yaz\u0131ya <a href=\"https:\/\/www.ortaakarsu.net\/?p=7261\">Covid-19 A\u015f\u0131s\u0131 %90 Etkili<\/a>&#8216;yi inceleyebilirsiniz.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"video-shortcode\"><iframe title=\"Covid-19 a\u015f\u0131s\u0131: A\u015f\u0131lar\u0131n birbirinden farklar\u0131 neler? A\u015f\u0131lar nas\u0131l da\u011f\u0131t\u0131lacak? So\u011fuk zincir nedir?\" width=\"1200\" height=\"675\" src=\"https:\/\/www.youtube.com\/embed\/YgzdWATzVic?start=1&#038;feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Covid-19 ve Yo\u011fun Bak\u0131m<\/h2>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"video-shortcode\"><iframe title=\"Koronavir\u00fcs: Ankara\u2019da yo\u011fun bak\u0131m\" width=\"1200\" height=\"675\" src=\"https:\/\/www.youtube.com\/embed\/iuSl0L__4ZU?start=50&#038;feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Favicovir Ne \u0130\u015fe Yarar<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Favicovir ne i\u015fe yarar <\/strong>\u00f6\u011frenmek i\u00e7in \u00f6ncelikle klinik \u00e7al\u0131\u015fmalar ba\u015fta olmak \u00fczere, litarat\u00fcrde bulunan veriler incelenmelidir. <strong>Favicovir kullananlar<\/strong> i\u00e7erisinde <strong>favicovir ne i\u015fe yarar<\/strong> sorusana tam bir cevap verememeyen ki\u015filer \u00e7o\u011funluktad\u0131r. Bilimsel litarat\u00fcr\u00fcn bilim insanlar\u0131 nezdinde derinlemesine takip edilmesi gerekse de her ila\u00e7 kullanan ki\u015finin ilac\u0131n nas\u0131l \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131 ve ne i\u015fe yarad\u0131\u011f\u0131n\u0131 bilmesi gerekmez. Yine de <strong>favicovir kullananlar <\/strong>yeni ve \u00fclkenizde \u00fcretilen bu ilac\u0131n ne i\u015fe yarad\u0131\u011f\u0131n\u0131 merak etmektedir. Bu ilac\u0131n ana hedevi koronavir\u00fcs <strong>RNA polimeraz<\/strong> enzimini inhibe etmektir. Yani covid19 vir\u00fcs\u00fcn\u00fcn belirli bir enzimini inhibe ederek hastal\u0131\u011f\u0131 tedavi etmektedir. Bu enzimin ne i\u015fe yarad\u0131\u011f\u0131n\u0131 ve tam mekanizmay\u0131 \u00f6\u011frenmek i\u00e7in yaz\u0131n\u0131n di\u011fer k\u0131s\u0131mlar\u0131n\u0131 okuyabilirsiniz. <\/p>\n\n\n\n<script async=\"\" src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\n<!-- Yatay_G\u00f6rnt\u00fcl\u00fc -->\n<ins class=\"adsbygoogle\" style=\"display:block\" data-ad-client=\"ca-pub-7050495227290123\" data-ad-slot=\"6780495801\" data-ad-format=\"auto\" data-full-width-responsive=\"true\"><\/ins>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script>\n\n\n\n<p class=\"wp-block-paragraph\">Favicovir haricinde farkl\u0131 ila\u00e7lar Covid19&#8217;a kar\u015f\u0131 etkili olmakta. Bunlar\u0131n hangi presiplere dayanarak de\u011ferlendirildi\u011fi ve tasarland\u0131\u011f\u0131 hem bu yaz\u0131n\u0131n devam\u0131nda hem de <a href=\"https:\/\/www.ortaakarsu.net\/?p=6856\">Yana\u015ft\u0131rma Nedir? Molek\u00fcler Docking Nas\u0131l Yap\u0131l\u0131r?<\/a> adl\u0131 yaz\u0131da a\u00e7\u0131klanmaktad\u0131r. Bu ila\u00e7lar i\u00e7erisinde <strong>remdesivir Covid-19 i\u00e7in resmi olarak onaylanan ilk ila\u00e7<\/strong> olma \u00f6zelli\u011fi ta\u015f\u0131maktad\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">K\u0131\u015f mevsimindeki grip vakalar\u0131n\u0131n covid19 hastal\u0131\u011f\u0131ndanbay\u0131rt edici olamas\u0131 i\u00e7in uygulanan grip a\u015f\u0131lar\u0131 <strong>Covid-19<\/strong> hatal\u0131\u011f\u0131ndan her hangi bir korma <strong>sa\u011flamamaktad\u0131r<\/strong>. Grip a\u015f\u0131lar\u0131, yani <strong>infuluenza a\u015f\u0131s\u0131<\/strong> i\u00e7in daha ayr\u0131nt\u0131l\u0131 bilgi edinmek i\u00e7in <a href=\"https:\/\/www.ortaakarsu.net\/?p=7176\">\u0130nfluenza A\u015f\u0131s\u0131 ve A\u015f\u0131 Olman\u0131n \u00d6nemi<\/a> adl\u0131 yaz\u0131y\u0131 okuyabilirsiniz. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Klinik \u00c7al\u0131\u015fmalar <\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u015eubat\u2019ta, Ulusal Enfeksiyon Hastal\u0131klar\u0131 Klinik T\u0131p Ara\u015ft\u0131rma Merkezi ve Shenzhen \u00dc\u00e7\u00fcnc\u00fc Halk Hastanesi taraf\u0131ndan ba\u015flat\u0131lan  COVID-19 tedavisi i\u00e7in favipiravir yani favicovir \u00fczerinde yap\u0131lan klinik bir dizi \u00e7al\u0131\u015fma umut verici sonu\u00e7 elde edilmesini sa\u011flam\u0131\u015ft\u0131r. Toplamda 80 kadar hastan\u0131n ( bu say\u0131 i\u00e7erisinde deney grubu ve  kontrol grubu da bulunmaktad\u0131r) ortaya \u00e7\u0131kan ilk sonu\u00e7lar\u0131, favipiravirin, lopinavir+ritonavirinkinden daha g\u00fc\u00e7l\u00fc bir antiviral etkiye sahip oldu\u011funu a\u00e7\u0131k\u00e7a g\u00f6stermi\u015ftir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Favicovir<\/strong> uygulanan tedavi grubunda anlaml\u0131 bir advers reaksiyon g\u00f6r\u00fclmemi\u015ftir ve lopinavir+ritonavir grubundan anlaml\u0131 olarak daha az yan etki g\u00f6stermi\u015ftir. Favipiravir, a\u011f\u0131rl\u0131ktan etkilenen kompleks, do\u011frusal olmayan, zaman ve doz ba\u011f\u0131ml\u0131 farmakokineti\u011fe sahiptir. Favipiravir, aldehit oksidaz enzimi ile hem metabolize hem de inhibe edildi\u011finden, yeterli kan seviyeleri elde etmek i\u00e7in ilk olarak oral y\u00fckleme yapmak gereklidir. Plazma yar\u0131 \u00f6mr\u00fc  4 saat kadard\u0131r.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Favicovir Kullanlar<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Favicovir kullananlar i\u00e7in koronavir\u00fcs hastal\u0131\u011f\u0131n\u0131n h\u0131zla iyile\u015fme s\u00fcrecine girdi\u011fi g\u00f6r\u00fcld\u00fc. Ancak belirli dozaj ayarlamas\u0131 ve zamanlamas\u0131 profesyonel sa\u011fl\u0131k \u00e7al\u0131\u015fanlar\u0131 taraf\u0131ndan yap\u0131lmal\u0131. Bu da \u00e7o\u011funlukla Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131m\u0131z\u0131n yay\u0131nlad\u0131\u011f\u0131 Covid-19 Rehberi \u00e7er\u00e7evesinde yap\u0131lmakta. Bu ilac\u0131n uygun dozda ve zamanda kullan\u0131lmas\u0131 hastal\u0131\u011f\u0131n iyile\u015fme s\u00fcrecine girmesinde b\u00fcy\u00fck etki g\u00f6steriyor. Bu, klinik deneyler ve kullan\u0131m bak\u0131m\u0131ndan <strong>Covid-19 RNA polimeraz<\/strong> enziminin etkili \u015fekilde inhibe edildi\u011fi, yani engellendi\u011fi anlam\u0131na geliyor. Bunlar ilk bulgular olmak ile birlikte olduk\u00e7a olumlu sonu\u00e7lar olarak g\u00f6ze \u00e7arp\u0131yor. \u0130lac\u0131n yan etkileri oldu\u011fundan yukar\u0131da bahsetmi\u015ftik. Bu yan etkilerin g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131n\u0131 favicovir baz\u0131nda indirecek herhangi bir y\u00f6ntem olmasa da yan etkilere kar\u015f\u0131 ba\u015fka ila\u00e7lar\u0131n kullan\u0131lmas\u0131yla, bu etkilerin \u00f6n\u00fcne ge\u00e7iliyor.<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">Favicovir Kullanlar i\u00e7in Psikolojik Etkiler Nelerdir? <\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">Bu ilac\u0131n psikolojik olarak herhangi bir etkisi oldu\u011fu ve yan etkilerinin bu y\u00f6nde oldu\u011funa dair \u00e7ok az veri vard\u0131r. \u0130la\u00e7 daha \u00e7ok ba\u015fka sistemler \u00fczerinde yan etki g\u00f6stermektedir. <strong>Favicovir yan etkileri<\/strong> neler, \u00f6\u011frenmek i\u00e7in \u00f6ncelikle, ilac\u0131n <strong>prospekt\u00fcse ba\u015fvurun<\/strong>.  Ayr\u0131ca <strong>belirgin yan etkilerin neler oldu\u011funu \u00f6\u011frenmek i\u00e7in <\/strong>bu yaz\u0131daki <strong>favicovir yan etkileri<\/strong> b\u00f6l\u00fcm\u00fcne bakabilirsiniz. E\u011fer ilac\u0131 kullanmakta olan bir hastaysan\u0131z beklenmedik yan etkilerde doktorunuzu bilgilendirin.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Favicovir&#8217;in Steroid S\u0131n\u0131f\u0131nda \u0130la\u00e7larla Birlikte Kullan\u0131m\u0131<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Favicovir<\/strong>, T\u00fcrkiye Cumhuriyeti Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131&#8217;n\u0131n Covid-19 tedavi rehberinde kullan\u0131ld\u0131\u011f\u0131 belirtilen bir ila\u00e7t\u0131r. Bu ilac\u0131n kullan\u0131m\u0131 normal tedavi prosed\u00fcr\u00fcnde bulunmaktad\u0131r. Bu ilac\u0131n yan\u0131nda verilen <strong>steroid s\u0131n\u0131f\u0131ndaki ila\u00e7lar\u0131n \u00f6l\u00fcm oranlar\u0131n\u0131 azaltt\u0131\u011f\u0131 y\u00f6n\u00fcnde a\u00e7\u0131klama yap\u0131lm\u0131\u015ft\u0131r. <\/strong>Burada \u00f6nemli nokta steroid s\u0131n\u0131f\u0131nda pek \u00e7ok ila\u00e7 bulunmas\u0131d\u0131r. Yani steroid denildi\u011finde akla sadece zararlar\u0131 kan\u0131tlanm\u0131\u015f ila\u00e7lar gelmemelidir. <strong>Testosteron da \u00f6strojen de steroid s\u0131n\u0131f\u0131ndad\u0131r<\/strong>. Ancak ikisinin g\u00f6revleri tabi ki farkl\u0131d\u0131r. Steroid s\u0131n\u0131f\u0131nda ila\u00e7lardan baz\u0131lar\u0131 son derece anaboliktir. Yan\u0131 b\u00fcy\u00fcmeyi uyar\u0131c\u0131 rolleri vard\u0131r. Bunlar\u0131n ba\u015f\u0131nda <strong>kortizon<\/strong> gelmektedir. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Koronavir\u00fcs hastal\u0131\u011f\u0131n\u0131n meydana getirmi\u015f oldu\u011fu<strong> a\u011f\u0131r i\u00e7 organ hasar\u0131 <\/strong>\u00f6l\u00fcme yol a\u00e7maktad\u0131r. Bu \u00f6l\u00fcmleri engellemek ve h\u00fccre geli\u015fimini, b\u00fcy\u00fcmesini ve \u00e7o\u011falmas\u0131n\u0131 uyarmak i\u00e7in anabolik s\u0131n\u0131f\u0131nda steroid ila\u00e7lar Covid19 hastal\u0131\u011f\u0131nda kullan\u0131lmaktad\u0131r. Favicovir ve di\u011fer ila\u00e7larla birlikte tedavi rehberine g\u00f6re belirli dozlarda verilen anabolik s\u0131n\u0131ftaki steroid ila\u00e7lar\u0131n faydal\u0131 oldu\u011fu a\u00e7\u0131klanm\u0131\u015ft\u0131r. <strong>Steroid molek\u00fcllerin<\/strong> di\u011fer \u00f6zelliklerini ve ayr\u0131nt\u0131l\u0131 \u00f6zelliklerini <a href=\"https:\/\/www.ortaakarsu.net\/?p=6805\">Testosteron ve Steroid Molek\u00fcller<\/a> adl\u0131 yaz\u0131dan \u00f6\u011frenebilirsiniz. Bu konuda yap\u0131lan ara\u015ft\u0131rmalar anabolik \u00f6zellikteki steroid molek\u00fcllerin i\u00e7 organ hasar\u0131n\u0131 onarma konusunda ba\u015far\u0131l\u0131 oldu\u011funu g\u00f6stermektedir.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Vir\u00fcslerle Sava\u015fta \u0130la\u00e7 Tasar\u0131m\u0131<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Vir\u00fcslere kar\u015f\u0131 belirli a\u015famalarda enzim veya resept\u00f6r inhibisyonu(resept\u00f6r\u00fcn inhibe edilmesi antogonis ad\u0131n\u0131 al\u0131r) ger\u00e7ekle\u015fir. Bu inhibisyonun \u015fiddeti ilac\u0131n etkisi ile orant\u0131l\u0131d\u0131r. Etken maddenin ilgili protein yap\u0131ya(yani enzime veya resept\u00f6re) afinitesi inhibisyon derecesini belirler. Viral integraz enziminin inhibe edilerek hastal\u0131kla m\u00fccadele edilmesi \u00f6nemli bir \u00f6rnekti. HIV v\u00fcr\u00fcs\u00fc ile m\u00fccadelere integraz inhibit\u00f6rlerinin ilki olarak kar\u015f\u0131m\u0131za \u00e7\u0131kan raltegravir viral integraz enzimini iyi bir \u015fekilde inhibe eder. \u0130ntegraz inhibit\u00f6rlerinin ilki olan raltegravir ile ilgili olarak daha fazla bilgi sahibi olunmas\u0131, HIV gibi s\u00fcrekli olarak mutasyon ge\u00e7iren ve m\u00fccadelesi son derece zor olan bir hastal\u0131kla m\u00fccadelede tam tedavi olmasa da ba\u015far\u0131 \u015fans\u0131n\u0131 artt\u0131rmaktad\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Antiviral ila\u00e7lar hastal\u0131k yap\u0131c\u0131 etkileri bak\u0131m\u0131ndan de\u011ferlendirilir ve vir\u00fcs\u00fcn kendi kal\u0131tsal bilgisini aktarmay\u0131 engelleyecek \u015fekilde tasarlananlar\u0131 vard\u0131r. Koronavir\u00fcs salg\u0131n\u0131 ile birlikte \u00e7ok\u00e7a duydu\u011fumuz antibody kavram\u0131 ise biraz farkl\u0131d\u0131r. Vir\u00fcs\u00fcn h\u00fccreye tutunmadan \u00f6nce etkisinin engellenmesi bu \u00e7al\u0131\u015fman\u0131n \u00f6nceli\u011fidir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Vir\u00fcslerle m\u00fccadele a\u015f\u0131 \u00e7al\u0131\u015fmalar\u0131n\u0131n \u00f6nemi b\u00fcy\u00fckt\u00fcr<\/strong>. \u00c7\u00fcnk\u00fc her hangi bir vir\u00fcs kaynakl\u0131 hastal\u0131\u011f\u0131n tedavi ve yay\u0131lmas\u0131n\u0131 engelle ile ilgili <strong>kesin \u00e7\u00f6z\u00fcm budur<\/strong>. Bu \u00e7al\u0131\u015fmalar son derece masrafl\u0131 olan ve e\u011fitimli insan gereksinimi y\u00fcksek olan \u00e7al\u0131\u015fmalard\u0131r. Bu \u00e7er\u00e7evede de\u011ferlendirdi\u011fimizde bir <strong>a\u015f\u0131 ke\u015ffi son derece zor bir s\u00fcre\u00e7 olarak kar\u015f\u0131m\u0131za \u00e7\u0131kar<\/strong>. Ancak her vir\u00fcs kaynakl\u0131 hastal\u0131\u011f\u0131n a\u015f\u0131s\u0131n\u0131n t\u00fcm gerekli ekipman ve bilgi birikimine sahip olunsa da bulunmas\u0131 zor olabilir. Bu konuda en iyi \u00f6rnek HIV vir\u00fcs\u00fcd\u00fcr. <strong>H\u0131zl\u0131 mutasyona ve de\u011fi\u015fime u\u011framas\u0131 ila\u00e7 tedavisini son derece zora sokmaktad\u0131r<\/strong>. Bu yaz\u0131n\u0131n bir sonraki b\u00f6l\u00fcm\u00fcne bununla ilgili bilgilere de ula\u015fman\u0131z i\u00e7in linkler bulunmaktad\u0131r. Bu s\u0131n\u0131ftaki koronavir\u00fcs\u00fcn viral enzimlerine kar\u015f\u0131 etkisi bildirilmemi\u015ftir. Bu ila\u00e7lar\u0131n kullan\u0131m\u0131 hastan\u0131n a\u011f\u0131r doku hasar\u0131n\u0131 onarmaya y\u00f6neliktir.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Ba\u015fka \u0130la\u00e7lar<\/h3>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"video-shortcode\"><iframe title=\"A\u015f\u0131 nedir? Nas\u0131l \u00e7al\u0131\u015f\u0131r? - &quot;A\u015f\u0131 belgeseli 2. B\u00f6l\u00fcm&quot;\" width=\"1200\" height=\"675\" src=\"https:\/\/www.youtube.com\/embed\/vNVcpCvF9-4?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><figcaption>Favicovir a\u015f\u0131 bulununcaya kadar etkili bir ila\u00e7 olmas\u0131 konusunda \u00f6nemli bir adayd\u0131r. <\/figcaption><\/figure>\n\n\n\n<script async=\"\" src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\n<!-- Yatay_G\u00f6rnt\u00fcl\u00fc -->\n<ins class=\"adsbygoogle\" style=\"display:block\" data-ad-client=\"ca-pub-7050495227290123\" data-ad-slot=\"6780495801\" data-ad-format=\"auto\" data-full-width-responsive=\"true\"><\/ins>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script>\n\n\n\n<p class=\"wp-block-paragraph\">Bu konu ile ve HIV vir\u00fcs\u00fcne kar\u015f\u0131 kullan\u0131lan ila\u00e7lar\u0131n nas\u0131l tasarland\u0131\u011f\u0131 ile ilgili olarak <a href=\"https:\/\/www.ortaakarsu.net\/?p=6606\">Raltegravir \u2013 \u0130ntegraz \u0130nhibit\u00f6rlerinin \u0130lki<\/a> adl\u0131 yaz\u0131y\u0131 okuyabilir ve ilgili videoyu izleyebilirsiniz. Yeni Koronavirs ila\u00e7 geli\u015ftirme ile ilgili son geli\u015fmeleri takip etmek i\u00e7in s\u00fcrekli g\u00fcncellenen <a href=\"https:\/\/www.ortaakarsu.net\/?p=6671\">Koronavir\u00fcs \u0130la\u00e7 Geli\u015ftirme \u00c7al\u0131\u015fmalar\u0131<\/a> yaz\u0131s\u0131n\u0131 devaml\u0131 takip edebilirsiniz. Bu sayfada yap\u0131lan son \u00e7al\u0131\u015fmalardan derlemeler ve koronavir\u00fcs ila\u00e7 geli\u015ftirme alan\u0131nda etkili olmas\u0131 beklenen molek\u00fcller ayr\u0131nt\u0131yla incelenmektedir. Bu \u00e7al\u0131\u015fmalarda kullan\u0131lan yap\u0131 bazl\u0131 ila\u00e7 tasar\u0131m\u0131 da ayr\u0131ca anlat\u0131lmaktad\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Favicovir<\/strong> de ayn\u0131 \u015fekilde belirli protein yap\u0131lar\u0131n\u0131 hedeflemektedir. Bu hedef protein yap\u0131lar\u0131 enfekte olunan andan itibaren \u00e7e\u015fitli a\u015famalarda i\u015flev g\u00f6steren enzim veya resept\u00f6rlerdir. \u0130yi bir etki i\u00e7in \u00e7oklu hedefleme yapan molek\u00fcller tercih edilmektedir. Daha iyi anla\u015f\u0131lmas\u0131 i\u00e7in; vir\u00fcs\u00fcn ba\u011fland\u0131\u011f\u0131 <strong>AC2 resept\u00f6r\u00fcnde<\/strong> engelleme yaparken ayn\u0131 zamanda vir\u00fcs\u00fcn kendi genetik materyallerini kopyalad\u0131\u011f\u0131 a\u015famada kullan\u0131lan enzimi de engellemektedir. Bu \u00f6zellikler bir ilac\u0131 g\u00fc\u00e7l\u00fc yaparken ayn\u0131 zamanda sinerjik etki dedi\u011fimiz hadiseyi de meydana getirmektedir. Yani iki ayr\u0131 yerdeki etki birbirini g\u00fc\u00e7lendirmekte b\u00f6ylelikle tek bir yerdeki etkiden daha fazla etki etki sa\u011flanmaktad\u0131r. Yani iki art\u0131 iki e\u015fittir be\u015f gibi bir sonu\u00e7 \u00e7\u0131kmaktad\u0131r.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Covid-19 i\u00e7in Tasarlanan \u0130la\u00e7lar\u0131n Hedefleri<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Favicovir de dahil olmak \u00fczere Kovid-19 i\u00e7in geli\u015ftirilen ila\u00e7lar belirli enzimleri veya resept\u00f6rleri hedeflertirler. Anti-covid-19 i\u00e7in tasarlanan ila\u00e7lar\u0131n ba\u015fl\u0131ca hedefleri aras\u0131nda <strong>ACE2<\/strong>, <strong>\u00e7e\u015fitli proteazlar (TMPRSS2, furin, 3CL, PL)<\/strong>, <strong>RdRp<\/strong> olarak ifade edilen; <strong>S1<\/strong>, bir resept\u00f6r ba\u011flanma b\u00f6lgesi ifade eder (RBD) ve <strong>f\u00fczyon peptidi (FP) S2<\/strong>&#8216;den olu\u015fan<strong> ba\u015fak glikoprotein<\/strong>,  <strong>HR1 ve HR2 b\u00f6lgeleri<\/strong>; ve aralar\u0131nda bulunan bir ba\u011flant\u0131 alan\u0131 (CD) vard\u0131r. Burada unutulmamas\u0131 gereken koronavir\u00fcslerin genel \u00f6zellikleridir. <strong>Koronavir\u00fcsler tek zincirli, pozitif polariteli, zarfl\u0131 RNA vir\u00fcsleridir<\/strong>. Pozitif polariteli olduklar\u0131 i\u00e7in RNA\u2019ya ba\u011f\u0131ml\u0131 RNA polimeraz enzimi i\u00e7ermezler, ancak genomlar\u0131nda bu enzimi kodlarlar. Y\u00fczeylerinde \u00e7ubuksu uzant\u0131lar\u0131 vard\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bu bilgilerden de anla\u015f\u0131laca\u011f\u0131 gibi favipiravir yani <strong>favicovir<\/strong>, <strong>RNA polimeraz<\/strong> enzimini inhibe ederek etki g\u00f6stermektedir. Ayn\u0131 enzime etki eden remdesivir de covid-19 i\u00e7in kullan\u0131lan bir ila\u00e7t\u0131r. Yukar\u0131da g\u00f6rm\u00fc\u015f oldu\u011funuz g\u00f6rselde covid-19 ile ilgili b\u00fct\u00fcn hedefler ve kullan\u0131lan ila\u00e7lar g\u00f6sterilmektedir. Bu g\u00f6rsele bakarak covid-19&#8217;un hangi a\u015famalarla bula\u015ft\u0131\u011f\u0131n\u0131 ve kendi genetik bilgisini \u00e7o\u011faltarak i\u015flev g\u00f6sterdi\u011fini g\u00f6rebilirsiniz.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Molek\u00fcler Docking ve Favicovir<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0130la\u00e7 tasar\u0131m\u0131ndaki ad\u0131mlar\u0131n ba\u015f\u0131nda ila\u00e7 molek\u00fcl\u00fcn\u00fcn bilgisayarda tasarlanmas\u0131 veya zaten bilinen ila\u00e7lar\u0131n yeniden ama\u00e7land\u0131rmas\u0131 gelmektedir. Yeniden ama\u00e7land\u0131rma kavram\u0131 \u00f6zellikle kovid-19&#8217;da oldu\u011fu gibi acil durunlarda tercih edilen bir y\u00f6ntemdir. \u00c7\u00fcnk\u00fc s\u0131f\u0131rdan bir molek\u00fcl tasarlay\u0131p piyasaya s\u00fcrmenin pek \u00e7ok zorlu\u011fu, masraf\u0131 ve uzun bir zaman\u0131 vard\u0131r. Yeniden ama\u00e7land\u0131rma ile ise zaten kullan\u0131lan(buna FDA onay\u0131 alm\u0131\u015f demek daha do\u011fru olabilir) molek\u00fcllerin yeni ortaya \u00e7\u0131kan hastal\u0131klardaki etkisinin modellenmesi yap\u0131lmaktad\u0131r. Bu a\u015famada, daha \u00f6nce sentezlenmi\u015f y\u00fczbinlerce molek\u00fcl denenebilmekte ve i\u00e7lerinden etkili olma olas\u0131l\u0131\u011f\u0131 olan molek\u00fcller, yerle\u015ftirme skorlar\u0131 ve molek\u00fcler dinamik \u00e7al\u0131\u015fmalar\u0131yla belirlenebilmektedir. B\u00f6ylelikle hastal\u0131\u011f\u0131n tedavisi ile hi\u00e7 ilgisi olmayan molek\u00fcllerin in vitro ve in vivo \u00e7al\u0131\u015fmalar\u0131n\u0131n yap\u0131lmas\u0131na gerek olmadan etkili olma olas\u0131l\u0131\u011f\u0131 olmayan molek\u00fcller listeden elenebilirler. <strong>Favicovir<\/strong>, yani favipiravir molek\u00fcl\u00fcn\u00fcn de bir anti viral olarak bilinmesi kovid-19 ile ilgili \u00e7al\u0131\u015fmalarda kullan\u0131lmas\u0131n\u0131 sa\u011flam\u0131\u015ft\u0131r.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-style-default\"><img decoding=\"async\" width=\"792\" height=\"660\" src=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/jz0c00994_0004-2.jpeg\" alt=\"Favipiravir etken maddesini de i\u00e7eren bir docking \u00e7al\u0131\u015fmas\u0131ndan al\u0131nt\u0131.\" class=\"wp-image-6651\" srcset=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/jz0c00994_0004-2-300x250.jpeg 300w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/jz0c00994_0004-2-500x417.jpeg 500w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/jz0c00994_0004-2-550x458.jpeg 550w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/jz0c00994_0004-2-700x583.jpeg 700w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/jz0c00994_0004-2-768x640.jpeg 768w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/jz0c00994_0004-2.jpeg 792w\" sizes=\"(max-width: 792px) 100vw, 792px\" \/><figcaption>Favicovir (Favipiravir) ve Di\u011fer \u0130la\u00e7lar\u0131n Covid-19 Ana Proteaz Enzimine Ba\u011flanma Afiniteleri. Yukar\u0131dan A\u015fa\u011f\u0131 Do\u011fru Afinite Artmaktad\u0131r. <br><a href=\"https:\/\/doi.org\/10.1021\/acs.jpclett.0c00994\">https:\/\/dx.doi.org\/10.1021\/acs.jpclett.0c00994<\/a><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Favicovir yani favipiravir, Kovid-19&#8217;un sadece RNA polimeraz enzimine etki etmez. Yukar\u0131da g\u00f6rm\u00fc\u015f oldu\u011funuz grafikte g\u00f6r\u00fcld\u00fc\u011f\u00fc gibi covid-19 ana proteaz enzimine etkisi vard\u0131r. Yap\u0131lan bu teorik \u00e7al\u0131\u015fma molek\u00fcler docking y\u00f6ntemi ile ger\u00e7ekle\u015ftirilmi\u015ftir. Molek\u00fcler docking ile ilgili daha \u00e7ok bilgi almak i\u00e7in <a href=\"https:\/\/www.ortaakarsu.net\/?p=6409\">Molek\u00fcler Docking ve \u0130la\u00e7 Tasar\u0131m\u0131nda Kullan\u0131m\u0131<\/a> ve <a href=\"https:\/\/www.ortaakarsu.net\/?p=75\">Kanser Tedavisinde \u0130la\u00e7lar ve Molek\u00fcler Docking<\/a> adl\u0131 yaz\u0131lar\u0131 okuyabilirsiniz. T\u00fcm bu \u00f6zellikler favicovir kullanlar i\u00e7in pek \u00e7ok bilgi kayna\u011f\u0131n\u0131 da beraberinde getirmektedir. Bu t\u00fcr \u00e7al\u0131imalar\u0131n yap\u0131ld\u0131\u011f\u0131, yeni olmayan yani \u00f6zelliklerinin b\u00fcy\u00fck bir k\u0131sm\u0131n\u0131n bilindi\u011fi bir ila\u00e7 art\u0131 ve eksi etkileri g\u00f6z \u00f6n\u00fcne al\u0131narak kullan\u0131lmas\u0131na karar verilebilir. <\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Benzer \u0130la\u00e7lar ile \u0130lgili \u00c7al\u0131\u015fmalar<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Bir ilac\u0131n tasar\u0131m\u0131nda ilk ad\u0131m olan molek\u00fcler docking ve sim\u00fclasyon \u00e7al\u0131\u015fmalar\u0131 kovid-19 i\u00e7in de kullan\u0131lmakta ve covid-19 ile ilgili enzimlerin engellenmesine y\u00f6nelik ilk veriler al\u0131nmaktad\u0131r. Hastal\u0131\u011f\u0131n son derece yeni olmas\u0131 ve bula\u015f oran\u0131n\u0131n \u00e7ok fazla olmas\u0131 \u015fuan i\u00e7in klinik \u00e7al\u0131\u015fmalar\u0131n hen\u00fcz bitmemi\u015f olmas\u0131 nedenlerin ba\u015f\u0131nda gelmektedir. Klinik \u00e7al\u0131\u015fmalar\u0131n hen\u00fcz tam anlam\u0131yla bitmemesi ve acil olarak tedavi-ila\u00e7 ihtiyac\u0131 ila\u00e7lar\u0131n yeniden ama\u00e7land\u0131r\u0131lmas\u0131n\u0131 da beraberinde getirmektedir.<strong> Favicovir de yeniden ama\u00e7land\u0131r\u0131lan bir ila\u00e7t\u0131r <\/strong>ve yaz\u0131n\u0131n ba\u015f\u0131nda bahsetti\u011fim hastal\u0131klar i\u00e7in zaten kullan\u0131lmaktad\u0131r. Etkili oldu\u011fu d\u00fc\u015f\u00fcn\u00fclen bir ba\u015fka ila\u00e7 olan remdesivir hakk\u0131nda g\u00fcncel bilgiler i\u00e7in <a href=\"https:\/\/www.ortaakarsu.net\/?p=7148\">Remdesivir, Covid-19 i\u00e7in Umut Vadeden \u0130la\u00e7<\/a> adl\u0131 yaz\u0131y\u0131 okuyabilirsiniz.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"video-shortcode\"><iframe title=\"Remdesivir ve Covid-19 RNA polimeraz kompleksi.\" width=\"1200\" height=\"675\" src=\"https:\/\/www.youtube.com\/embed\/CuPMc1zQD38?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><figcaption>RNA polimeraz enziminin engellenmesinde etkili olan remdesevir etken maddesinin protein yap\u0131ya ba\u011flanmas\u0131.<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Favicovir ve remdesevir<\/strong>, covid-19 i\u00e7in denenen iki ayr\u0131 ila\u00e7t\u0131r. \u0130kisi de ayn\u0131 viral enzime etki etmektir. Klinik \u00e7al\u0131\u015fmalar\u0131n hen\u00fcz \u00e7ok yeni olmas\u0131 hangi ilac\u0131n daha etkili oldu\u011funu s\u00f6ylemeyi zorla\u015ft\u0131rsa da eldeki mevcut verilerle milli ila\u00e7 olarak <strong>favicovir<\/strong> molek\u00fcl\u00fcn\u00fcn se\u00e7ildi\u011fini g\u00f6stermektedir. Ayr\u0131ca <a href=\"https:\/\/www.ortaakarsu.net\/?p=6899\">Risin Proteini<\/a> ve <a href=\"https:\/\/www.ortaakarsu.net\/?p=6980\">Lektin Proteinlerinin S\u0131n\u0131fland\u0131r\u0131lmas\u0131 ve \u00d6zellikleri<\/a> adl\u0131 yaz\u0131 da protein yap\u0131lar i\u00e7in daha fazla bilgi bulabilirsiniz. <\/p>\n\n\n\n<h4 class=\"wp-block-heading\">T\u00fcrkiye Cumhuriyeti Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 Koronavir\u00fcs Tedavi Prosed\u00fcr\u00fc<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>T\u00fcrkiye Cumhuriyeti Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131<\/strong>n\u0131n <a href=\"https:\/\/covid19bilgi.saglik.gov.tr\/tr\/covid-19-rehberi.html\">COVID-19 Rehberi<\/a> olarak hastal\u0131\u011f\u0131n tan\u0131nmas\u0131, tedavisi ve bunun gibi pek \u00e7ok konu ile farkl\u0131 kategorilerde haz\u0131rlad\u0131\u011f\u0131 rehberde tedavi s\u00fcrecinde kullan\u0131lan ila\u00e7lar da anlat\u0131lm\u0131\u015ft\u0131r. <strong>Covid19<\/strong> tedavisinde kullan\u0131lan ila\u00e7lar, ba\u015fka hastal\u0131klar \u00fczerinde klinik olaral de\u011ferlendirse de yeni <strong>koronavir\u00fcs<\/strong> \u00fczerinde \u00e7al\u0131\u015f\u0131lmalar devam etmektedir. T\u00fcrkiye Cumhuriyeti Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131n\u0131n ilac\u0131n etkisini test etti\u011fi ve etkili buldu\u011funu g\u00f6steren resmi yaz\u0131lar bulunmaktad\u0131r. Bu yaz\u0131lar\u0131n b\u00fct\u00fcn\u00fcne bakt\u0131\u011f\u0131m\u0131zda tedavi s\u00fcrecinin tek bir ila\u00e7la yap\u0131lmad\u0131\u011f\u0131 g\u00f6r\u00fclmektedir. Pek \u00e7ok ilac\u0131n farkl\u0131netkileri bir araya toplanmak istenerek daha g\u00fc\u00e7l\u00fc bir tedavi prosed\u00fcr\u00fc geliitirilmeye \u00e7al\u0131\u015f\u0131lmaktad\u0131r. Bu tedavi s\u00fcrecinde favipiravir ve liponavir \u00f6n plana \u00e7\u0131kmaktad\u0131r. <\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>COVID-19\u2019a \u00f6zg\u00fc bir tedavinin bulunmas\u0131 \u00e7ok zaman alaca\u011f\u0131 i\u00e7in, mevcut pandemi s\u0131ras\u0131nda \u00fclkemizde ve ba\u015fta Avrupa ve ABD olmak \u00fczere di\u011fer \u00fclkelerde bu hastal\u0131\u011fa kar\u015f\u0131 antiviral olarak, insanlarda daha \u00f6nce ba\u015fka hastal\u0131klar\u0131n tedavisi i\u00e7in ruhsatland\u0131r\u0131lm\u0131\u015f, bu endikasyonlarda yayg\u0131n bir \u015fekilde kullan\u0131lm\u0131\u015f, g\u00fcvenli oldu\u011fu g\u00f6sterilmi\u015f ve in vitro olarak SARS-CoV\u2019ye etkili oldu\u011fu belirlenmi\u015f hidroksiklorokin, <strong>favipiravir<\/strong>, <strong>remdesivir<\/strong>, lopinavir-ritonavir gibi ila\u00e7lar \u00f6nerilmi\u015f ve kullan\u0131lm\u0131\u015ft\u0131r. Bu ila\u00e7lar\u0131n COVID-19\u2019daki etkinli\u011fi ve g\u00fcvenilirli\u011fi konusunda \u00e7ok say\u0131da \u00e7al\u0131\u015fma halen devam etmektedir.<\/p><cite><a href=\"https:\/\/covid19bilgi.saglik.gov.tr\/depo\/rehberler\/covid-19-rehberi\/COVID-19_REHBERI_ERISKIN_HASTA_TEDAVISI.pdf\">https:\/\/covid19bilgi.saglik.gov.tr\/depo\/rehberler\/covid-19-rehberi\/COVID-19_REHBERI_ERISKIN_HASTA_TEDAVISI.pdf<\/a> Safya 14-15<\/cite><\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\">Covid 19 tedavisi i\u00e7in kullan\u0131lan di\u011fer ila\u00e7lar ile ilgili yaz\u0131lar\u0131 haz\u0131rlamaktay\u0131m. Bu ila\u00e7lar aras\u0131nda yeni koronavir\u00fcs i\u00e7in ana proteaz enzimine etkili oldu\u011fu belirtilen liponavir de yer alacakt\u0131r. Favicovir ve liponavir i\u00e7eren \u00e7al\u0131\u015fmalar\u0131n \u00f6zetlerine \u00f6ncelik verilecektir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Favicovir yani favipiravir i\u00e7in sa\u011fl\u0131k bakanl\u0131 taraf\u0131ndan yay\u0131nlanan bilgilendirme metni i\u00e7in <a href=\"https:\/\/covid19bilgi.saglik.gov.tr\/depo\/tedavi\/ilac\/FAVIPIRAVIR_200_MG_TABLET.pdf\">Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131n\u0131m Favipiravir<\/a> dosyas\u0131n\u0131 pdf format\u0131nda indirmek ve incelemek m\u00fcmk\u00fcn. <strong>Doktor tavsiyesi d\u0131\u015f\u0131nda ila\u00e7 kullan\u0131lmamas\u0131 gerekti\u011fini unutmay\u0131n\u0131z.<\/strong> <\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Favicovir Sentezi<\/h2>\n\n\n<div class=\"wp-block-image is-style-default\">\n<figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/favicovir.png\" alt=\"Favicovir molek\u00fcl\u00fcn\u00fcn yap\u0131s\u0131\" class=\"wp-image-6656\" width=\"341\" height=\"234\"\/><figcaption>Favicovir Molek\u00fcl\u00fc <\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Molek\u00fcl bir <strong>prazin t\u00fcrevidir<\/strong> ve pirazin halkas\u0131na  flor, hidroksil, amit fonksiyonel gruplar\u0131 ba\u011flanm\u0131\u015ft\u0131r. Molek\u00fcl\u00fcn sistematik ad\u0131 6-fluoro-3-hydroxypyrazine-2-carboxamide&#8217;dir. T\u00fcrk\u00e7eye \u00e7evirirsek 6-floro-3-hidroksipirazin-2-carboksiamid olarak okunur. Molek\u00fcl 157 g\/mol k\u00fctleye sahiptir. Molek\u00fcl\u00fc bir ila\u00e7 olarak inceledi\u011fimize g\u00f6re Lipinski&#8217;nin&nbsp;<strong><em><strong><em>Be\u015fli kural\u0131<\/em><\/strong><\/em><\/strong> denilen ve iyi bir ila\u00e7ta bulunmas\u0131 gereken \u00f6zellikleri ifade eden \u00f6l\u00e7eklerde uygun sonu\u00e7lar verdi\u011fi g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. Nispeten d\u00fc\u015f\u00fck molek\u00fcl a\u011f\u0131rl\u0131\u011f\u0131 da bu \u00e7ervevede de\u011ferlendirildi\u011finde olumlu bir \u00f6zellik olarak g\u00f6ze \u00e7arpmaktad\u0131r. Molek\u00fcl\u00fcn karboksiamid yap\u0131s\u0131 t\u00fcrevlendirme i\u015flemini kolayla\u015ft\u0131rsa da bu ilac\u0131n t\u00fcrevlerinin, covid19 hastal\u0131\u011f\u0131na kar\u015f\u0131 kullan\u0131ld\u0131\u011f\u0131 \u00e7al\u0131\u015fmalar hen\u00fcz yoktur. Molek\u00fcl\u00fcn kapal\u0131 form\u00fcl\u00fc C<sub>5<\/sub>H<sub>4<\/sub>FN<sub>3<\/sub>O<sub>2<\/sub> dir. A\u00e7\u0131k yap\u0131s\u0131 yukar\u0131da g\u00f6r\u00fcld\u00fc\u011f\u00fc gibidir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Favicovir bir dizi organik tepkime sonucunda sentezlenmektedir. Tek bir molek\u00fcl\u00fcn sentezlenmesinde dahi birden fazla strateji oldu\u011fu d\u00fc\u015f\u00fcn\u00fcl\u00fcrse \u015fuan \u00fclkemizde kovid-19&#8217;a kar\u015f\u0131 seri \u00fcretimi yap\u0131lan bu ilac\u0131n hangi strateji \u00fcretildi\u011fini s\u00f6ylemek zordur. Bilim adamlar\u0131m\u0131z bilinen stratejiileri kullanabilecekleri gibi kendi stratejilerini de geli\u015ftirmi\u015f olabilir. Daha \u00f6nce akademik yay\u0131nlarda yap\u0131lan \u00fc\u00e7 farkl\u0131 sentez \u015femas\u0131 a\u015fa\u011f\u0131da verilmi\u015ftir.<\/p>\n\n\n\n<figure class=\"wp-block-image is-style-default\"><img decoding=\"async\" src=\"https:\/\/media.springernature.com\/full\/springer-static\/image\/art%3A10.1007%2Fs11696-018-0654-9\/MediaObjects\/11696_2018_654_Sch1_HTML.png\" alt=\"Favicovir sentez \u015femas\u0131\"\/><figcaption><strong>Favicovir<\/strong> (yani favipiravir) molek\u00fcl\u00fcn\u00fcn sentezezine ait bir \u015femas\u0131<strong>.<\/strong><br><a href=\"https:\/\/doi.org\/10.1007\/s11696-018-0654-9\">https:\/\/doi.org\/10.1007\/s11696-018-0654-9<\/a><\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image is-style-default\"><img decoding=\"async\" src=\"https:\/\/media.springernature.com\/full\/springer-static\/image\/art%3A10.1007%2Fs11696-018-0654-9\/MediaObjects\/11696_2018_654_Sch4_HTML.png\" alt=\"Favicovir sentez \u015femas\u0131\"\/><figcaption><strong>Favicovir<\/strong> (yani favipiravir) molek\u00fcl\u00fcn\u00fcn sentezezine ait genel bir \u015femas\u0131<strong>.<\/strong> \u00c7al\u0131\u015fman\u0131n sahiplerinin tercih etti\u011fi yol k\u0131zm\u0131z\u0131 ile i\u015faretlidir.<br><a href=\"https:\/\/doi.org\/10.1007\/s11696-018-0654-9\">https:\/\/doi.org\/10.1007\/s11696-018-0654-9<\/a><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Favicovir sentezi <\/strong>izlenen yola g\u00f6re de\u011fi\u015fen say\u0131da basamakta sentezlenebiliyor. Kataliz\u00f6r kullan\u0131m\u0131n\u0131n da bulundu\u011fu tepkime basamaklar\u0131, izlenilen stratejiyi h\u0131z ve verimlilik gibi konularda bir birinden ay\u0131rmakta. Salg\u0131n hastal\u0131k ile m\u00fccade etti\u011fimiz bu s\u00fcre\u00e7te h\u0131zl\u0131 ve etkili bir \u015fekilde ila\u00e7 kullan\u0131m\u0131na ihtiya\u00e7 duyuldu\u011fu g\u00f6z \u00f6n\u00fcne al\u0131nd\u0131\u011f\u0131nda sentez stratejisinin do\u011fru belirlenmesi b\u00fcy\u00fck \u00f6nem ta\u015f\u0131maktad\u0131r.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Sentezden Sonra &#8211; Koronavir\u00fcs \u0130la\u00e7 Etken Maddesi Olarak Kullan\u0131m<\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1880\" height=\"1253\" src=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/headache-pain-pills-medication-159211.jpeg\" alt=\"bunch of white oval medication tablets and white medication capsules\" class=\"wp-image-6732\" srcset=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/headache-pain-pills-medication-159211-300x200.jpeg 300w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/headache-pain-pills-medication-159211-500x333.jpeg 500w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/headache-pain-pills-medication-159211-550x367.jpeg 550w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/headache-pain-pills-medication-159211-700x467.jpeg 700w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/headache-pain-pills-medication-159211-768x512.jpeg 768w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/headache-pain-pills-medication-159211-1024x682.jpeg 1024w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/headache-pain-pills-medication-159211-1536x1024.jpeg 1536w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/headache-pain-pills-medication-159211.jpeg 1880w\" sizes=\"(max-width: 1880px) 100vw, 1880px\" \/><figcaption>\u0130la\u00e7lar \u00f6nceden belirlenen form\u00fclasyon ile verilirler.<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">En etkili form\u00fclasyonun bulunmas\u0131 b\u00fcy\u00fck oranda deneme yan\u0131lma ve form\u00fclasyon bilgisi gerektirmektedir. Her ila\u00e7 belirli bir form\u00fclasyon ile tedavide kullan\u0131l\u0131r. Form\u00fclasyondaki k\u00fc\u00e7\u00fck farklar b\u00fcy\u00fck etkiler yarat\u0131r. Form\u00fclasyonlar, ila\u00e7 sal\u0131m\u0131 gibi konularda ve ilac\u0131n etkinli\u011fi konusunda olduk\u00e7a \u00f6nemlidir. Her farkl\u0131 form\u00fclasyon bir bir denenerek en etkili olan\u0131 bulunur. Yine ilac\u0131n raf \u00f6mr\u00fc gibi konularda form\u00fclasyonda belirleyici prensipler i\u00e7erisindedir. \u0130la\u00e7lar\u0131n belirli bir raf \u00f6m\u00fcrleri olsun istenir ve koruyucu maddeler ilaca kat\u0131larak bu uygun \u015fekilde ayarlan\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bu ilac\u0131n Japon men\u015feli oldu\u011funu yaz\u0131n\u0131n ba\u015f\u0131nda ifade etmi\u015ftik. Molek\u00fcl bulunup etkisi kan\u0131tlanm\u0131\u015f ve seri \u00fcretime ge\u00e7ilmi\u015f bir ila\u00e7t\u0131r. Biz bu ilac\u0131 kendi markam\u0131z ad\u0131 alt\u0131nda molek\u00fcl yap\u0131s\u0131 ayn\u0131 olacak \u015fekilde sentezleyip ila\u00e7 olarak <strong>coronavirus tedavisinde<\/strong> kullan\u0131yoruz. Etken madde sentezledikten sonra belirli katk\u0131 maddelerini, belirli miktarda kullanarak <strong>form\u00fclasyon<\/strong> ile son kullan\u0131c\u0131 i\u00e7in \u00fcretiyoruz. <strong>Form\u00fclasyon<\/strong> kullan\u0131m\u0131n\u0131n, yani etken maddenin neden direkt olarak verilmedi\u011fini daha \u00f6nce a\u00e7\u0131klam\u0131\u015ft\u0131m. <strong>Form\u00fclasyon<\/strong> ilac\u0131n etkisi ba\u015fta olmak \u00fczere pek \u00e7ok fakt\u00f6re etki etmektedir. <\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u0130la\u00e7 Tasar\u0131m\u0131n\u0131n Temel Prensipleri ve Favicovir<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0130lac\u0131n kimyasal yap\u0131s\u0131na ve <a href=\"https:\/\/www.ortaakarsu.net\/?p=6403\">Bilgisayar Destekli \u0130la\u00e7 Tasar\u0131m\u0131 (CADD)<\/a> yaz\u0131s\u0131nda anlat\u0131lan ADME, Lipinski Kurallar\u0131 \u00e7er\u00e7evesinde yap\u0131lan de\u011ferlendirmede 157 g\/mol gibi d\u00fc\u015f\u00fck molek\u00fcl k\u00fctlesi de ba\u015fta olmak \u00fczere pek \u00e7ok a\u00e7\u0131dan ila\u00e7 tasar\u0131m prensiplerine uygun bir molek\u00fcld\u00fcr. LogP de\u011feri d\u00fc\u015f\u00fckt\u00fcr. Molek\u00fcl belirli <strong>form\u00fclasyonlarla<\/strong> ila\u00e7 \u015feklinde kullan\u0131lmaktad\u0131r(<em>her ila\u00e7 da oldu\u011fu gibi<\/em>). Bu form\u00fclasyonlar \u00fcreticiden \u00fcreticiye de\u011fi\u015fmektedir. Buradaki temel prensip etken maddenin, yani <strong>favicovir kullanlar<\/strong> i\u00e7in, ilac\u0131n etkisinin en y\u00fcksek seviyede olmas\u0131n\u0131 sa\u011flamak, ilac\u0131n kana ge\u00e7i\u015f s\u00fcresini ayarlamak(ila\u00e7 sal\u0131m\u0131) ve bunun gibi pek \u00e7ok \u00f6zellikten \u00f6t\u00fcr\u00fcd\u00fcr. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0130la\u00e7 bir form\u00fclasyon halinde verilmekte, yani tek ba\u015f\u0131na kullan\u0131lmamaktadir. Koronavir\u00fcs ila\u00e7 geli\u015ftirme \u00e7al\u0131\u015fmalar\u0131 i\u00e7in her zaman g\u00fcncel tutulacak olan <a href=\"https:\/\/www.ortaakarsu.net\/?p=6671\">Koronavir\u00fcs \u0130la\u00e7 Geli\u015ftirme \u00c7al\u0131\u015fmalar\u0131<\/a> adl\u0131 yaz\u0131 ile son geli\u015fmelerden her zaman haberdar olabilirsiniz. Korocavir\u00fcs ila\u00e7 geli\u015ftirme \u00e7al\u0131\u015fmalar\u0131 d\u00fcnyan\u0131n bu konuda yeni ila\u00e7lara ve mevcut ila\u00e7lar\u0131n yeniden ama\u00e7land\u0131r\u0131labilir olanlar\u0131na acil ihtiya\u00e7 duymas\u0131 sonucunda son derece h\u0131zl\u0131 ilerlemektedir. D\u00fcnya a\u015f\u0131 bulunana kadar bu ila\u00e7lara ve olunlu etkilerine muhta\u00e7 olacakt\u0131r. Durum bunu g\u00f6stermekte ve <strong>favicovir yan etkileri kullananlar<\/strong> i\u00e7in tedavi s\u00fcreleri k\u0131salmaktad\u0131r. Ancak unutulmamal\u0131d\u0131r ki, bu tedaviler her zaman kesin \u00e7\u00f6z\u00fcm niteli\u011fi ta\u015f\u0131mamakta, \u00f6zellikle belirli ya\u015f aral\u0131klar\u0131nda ki insanlar i\u00e7in koronavir\u00fcs\u00fcn seyri de\u011fi\u015fmektedir. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Favicovir Yan Etkiler Favicovir kullananlarda en s\u0131k g\u00f6r\u00fclen yan etkiler:  [&#8230;]<\/p>\n","protected":false},"author":1,"featured_media":6657,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[122],"tags":[133,135,8,131,136,132,134,138,137],"class_list":["post-6628","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-molekul","tag-covid","tag-covid19","tag-docking","tag-favicovir","tag-favicovir-yan-etkileri","tag-favipiravir","tag-koronavirus","tag-kovid","tag-kovid19"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/6628","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6628"}],"version-history":[{"count":6,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/6628\/revisions"}],"predecessor-version":[{"id":7978,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/6628\/revisions\/7978"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/media\/6657"}],"wp:attachment":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6628"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6628"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6628"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}