{"id":6937,"date":"2020-09-30T15:55:12","date_gmt":"2020-09-30T12:55:12","guid":{"rendered":"https:\/\/www.ortaakarsu.net\/?p=6937"},"modified":"2020-10-05T16:08:34","modified_gmt":"2020-10-05T13:08:34","slug":"hgh-yani-insan-buyume-hormonu-nedir","status":"publish","type":"post","link":"https:\/\/www.ortaakarsu.net\/?p=6937","title":{"rendered":"hGH, yani \u0130nsan B\u00fcy\u00fcme Hormonu Nedir?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>hGH<\/strong> yani <strong>insan b\u00fcy\u00fcme hormonu<\/strong>(<strong>DOI:&nbsp;<\/strong><a rel=\"noreferrer noopener\" href=\"http:\/\/doi.org\/10.2210\/pdb1HGU\/pdb\" target=\"_blank\">10.2210\/pdb1HGU\/pdb<\/a>) ile ilgili \u00e7al\u0131\u015fmalar 100 y\u0131ldan biraz daha eskidir. \u0130lk olarak boy uzunlamas\u0131 \u00fczerindeki b\u00fcy\u00fcmeye dramatik etkisiyle tan\u0131mlanan b\u00fcy\u00fcme hormonunun art\u0131k <strong>protein<\/strong>, <strong>lipid<\/strong> ve karbonhidrat metabolizmas\u0131 \u00fczerinde genelle\u015ftirilmi\u015f etkileri oldu\u011fu art\u0131k bilinmektedir. \u0130nsan fizyolojisinde b\u00fcy\u00fcme hormonu i\u00e7in ek rollerin <strong>uyku ara\u015ft\u0131rma ve \u00fcreme alanlar\u0131nda<\/strong> ke\u015ffedilmesi muhtemeldir. Ayr\u0131ca, b\u00fcy\u00fcme hormonunun <strong>ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonunun<\/strong>, <strong>zihinsel sa\u011fl\u0131\u011f\u0131n<\/strong> ve <strong>ya\u015flanma s\u00fcrecinin<\/strong> d\u00fczenlenmesinde de rol oynayabilece\u011fine dair baz\u0131 g\u00f6stergeler vard\u0131r.<\/p>\n\n\n\n<figure class=\"wp-block-embed-youtube wp-block-embed is-type-video is-provider-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"video-shortcode\"><iframe title=\"\u0130nsan B\u00fcy\u00fcme Hormonu(hGH) &#039;nin 3D G\u00f6r\u00fcnt\u00fcs\u00fc PDB:1HGU\" width=\"1200\" height=\"675\" src=\"https:\/\/www.youtube.com\/embed\/xIswQ9NotFo?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><figcaption>\u0130nsan B\u00fcy\u00fcme Hormonu 3D g\u00f6r\u00fcnt\u00fcs\u00fc<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>B\u00fcy\u00fcme hormonu<\/strong> salg\u0131layan fakt\u00f6r\u00fcn hipotalamik sal\u0131n\u0131m\u0131, b\u00fcy\u00fcme hormonu salg\u0131lanmas\u0131n\u0131 te\u015fvik eder. <strong>hGH<\/strong> v\u00fccut b\u00fcy\u00fcmesini uyar\u0131r;<strong> IGF-1 sekresyonunu artt\u0131r\u0131r<\/strong>; <strong>lipidlerin par\u00e7alanmas\u0131n\u0131 uyar\u0131r<\/strong>; karbonhidrat ve lipit metabolizmas\u0131 \u00fczerinde ins\u00fclin ile ili\u015fkili konular da etkisi kayda de\u011ferdir. Genel olarak, <strong>hGH, v\u00fccutta b\u00fcy\u00fcyebilen hemen hemen her dokuda b\u00fcy\u00fcmeye neden olur.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Rekombinant DNA teknolojisi, insan kullan\u0131m\u0131 i\u00e7in pahal\u0131 olsa da bol ve g\u00fcvenli bir b\u00fcy\u00fcme hormonu kayna\u011f\u0131 sa\u011flam\u0131\u015ft\u0131r<\/strong>. Bu teknoloji bilimin geldi\u011fi son noktan\u0131n bir g\u00f6stergesi niteli\u011findedir denebilir, ancak b\u00fcy\u00fcme hormonunun farmakolojik \u00f6zellikleri zay\u0131ft\u0131r. <strong>B\u00fcy\u00fcme hormonu eksikli\u011fi <\/strong>olan \u00e7o\u011fu birey, b\u00fcy\u00fcme hormonu \u00fcretiminde birincil kusurdan ziyade bir<strong> salg\u0131lama eksikli\u011finden<\/strong> muzdariptir. Ancak b\u00fcy\u00fcme hormonu salg\u0131lanmas\u0131n\u0131n <strong>n\u00f6roendokrin<\/strong> d\u00fczenlemesine ili\u015fkin anlay\u0131\u015f\u0131m\u0131zdaki geli\u015fmeler, endojen olarak sentezlenmi\u015f salg\u0131lanmay\u0131 uyarmak i\u00e7in ila\u00e7lar\u0131n kullan\u0131m\u0131n\u0131n temelini olu\u015fturmu\u015ftur. Bu, gelecekteki ila\u00e7 geli\u015fimi i\u00e7in \u00f6nemli bir alan olmay\u0131 vaat etmektedir.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u0130nsan B\u00fcy\u00fcme Hormonu Yap\u0131s\u0131 (hGH)<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0130nsan b\u00fcy\u00fcme hormonunun (hGH) <\/strong>resept\u00f6r\u00fcne ba\u011flanmas\u0131, normal insan b\u00fcy\u00fcmesinin ve geli\u015fiminin d\u00fczenlenmesi i\u00e7in gereklidir. Resept\u00f6rler ve hormon resept\u00f6r etkile\u015fimi ilgili daha fazla bilgi i\u00e7in <a href=\"https:\/\/www.ortaakarsu.net\/?p=6805\">Testosteron ve Steroid Molek\u00fcller<\/a> adl\u0131 yaz\u0131y\u0131 okuyabilirsiniz.<a href=\"https:\/\/www.rcsb.org\/structure\/2XDG\"> Hormon ve resept\u00f6r\u00fcn\u00fcn h\u00fccre d\u0131\u015f\u0131 alan\u0131 (hGHbp) <\/a>aras\u0131ndaki kompleksin <strong>2.8 angstrom kristal yap\u0131s\u0131<\/strong>n\u0131n incelenmesi(<strong>DOI:&nbsp;<\/strong><a href=\"http:\/\/doi.org\/10.2210\/pdb2XDG\/pdb\" target=\"_blank\" rel=\"noreferrer noopener\">10.2210\/pdb2XDG\/pdb<\/a>), kompleksin <strong>iki resept\u00f6r molek\u00fcl\u00fc ba\u015f\u0131na bir b\u00fcy\u00fcme hormonu molek\u00fcl\u00fcnden olu\u015ftu\u011funu g\u00f6sterdi<\/strong>.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"401\" height=\"401\" src=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_ust_gorsel-edited.png\" alt=\"\u0130nsan B\u00fcy\u00fcme Hormonu(hGH) farkl\u0131 bir a\u00e7\u0131dan g\u00f6r\u00fcnt\u00fc.\" class=\"wp-image-6946\" srcset=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_ust_gorsel-edited-90x90.png 90w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_ust_gorsel-edited-150x150.png 150w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_ust_gorsel-edited-200x200.png 200w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_ust_gorsel-edited-250x250.png 250w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_ust_gorsel-edited-300x300.png 300w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_ust_gorsel-edited.png 401w\" sizes=\"(max-width: 401px) 100vw, 401px\" \/><figcaption>\u0130nsan B\u00fcy\u00fcme Hormonu(hGH) Molek\u00fcl\u00fc tek ba\u015f\u0131na.<br>PDB: <a href=\"https:\/\/www.rcsb.org\/structure\/1HGU\">1HGU<\/a><br><strong>DOI:&nbsp;<\/strong><a href=\"http:\/\/doi.org\/10.2210\/pdb1HGU\/pdb\" target=\"_blank\" rel=\"noreferrer noopener\">10.2210\/pdb1HGU\/pdb<\/a><\/figcaption><\/figure><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"758\" height=\"401\" src=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_reseptore_baglil.png\" alt=\"iki resept\u00f6r molek\u00fcl\u00fc ba\u015f\u0131na bir hGH molek\u00fcl\u00fc kompleks halde\" class=\"wp-image-6948\" srcset=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_reseptore_baglil-300x159.png 300w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_reseptore_baglil-500x265.png 500w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_reseptore_baglil-550x291.png 550w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_reseptore_baglil-700x370.png 700w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_reseptore_baglil.png 758w\" sizes=\"(max-width: 758px) 100vw, 758px\" \/><figcaption>\u0130ki resept\u00f6r molek\u00fcl\u00fc ba\u015f\u0131na bir <strong>insan b\u00fcy\u00fcme hormonu(hGH) molek\u00fcl kompleks halde<\/strong> g\u00f6r\u00fcn\u00fc\u015f\u00fc. <br>PDB: <a href=\"https:\/\/www.rcsb.org\/structure\/1HWG\">1HWG<\/a> <br><strong>DOI:&nbsp;<\/strong><a href=\"http:\/\/doi.org\/10.2210\/pdb1HWG\/pdb\" target=\"_blank\" rel=\"noreferrer noopener\">10.2210\/pdb1HWG\/pdb<\/a><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Hormon, al\u0131\u015f\u0131lmad\u0131k bir topolojiye sahip d\u00f6rt sarmall\u0131 bir demettir. Ba\u011flanma proteini, baz\u0131 a\u00e7\u0131lardan imm\u00fcnoglobulin alanlar\u0131na benzer iki farkl\u0131 alan i\u00e7erir. Bu alanlar\u0131n g\u00f6receli oryantasyonu, imm\u00fcnoglobulin Fab fragmanlar\u0131nda sabit ve de\u011fi\u015fken alanlar aras\u0131nda bulunandan farkl\u0131d\u0131r. \u0130nsan b\u00fcy\u00fcme hormonu (hGH), somatotroplar ad\u0131 verilen bir hormon s\u0131n\u0131f\u0131na aittir. hGH, tek bir zincir halinde derlenen 191 amino asitten olu\u015fur. Protein-protein etkile\u015fimi haricinde ligand-protein etkile\u015fimine en iyi \u00f6rnekler <a href=\"https:\/\/www.ortaakarsu.net\/?p=6805\">Testosteron ve Steroid Molek\u00fcller<\/a> ve <a href=\"https:\/\/www.ortaakarsu.net\/?p=6566\">Tamoksifen Sitrat<\/a> adl\u0131 yaz\u0131larda anlat\u0131lmaktad\u0131r. Bu yaz\u0131lar hem ligand-resept\u00f6r etkile\u015fimini hem resept\u00f6r\u00fcn inhibe edilme s\u00fcre\u00e7lerini ayr\u0131nt\u0131s\u0131 ile almaktad\u0131r.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_yan_gorsel-edited.png\" alt=\"insan b\u00fcy\u00fcme hormonu(hGH)'nin yap\u0131s\u0131.\" class=\"wp-image-6944\" width=\"400\" height=\"400\" srcset=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_yan_gorsel-edited-90x90.png 90w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_yan_gorsel-edited-150x150.png 150w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_yan_gorsel-edited-200x200.png 200w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_yan_gorsel-edited-250x250.png 250w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_yan_gorsel-edited-300x300.png 300w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hGH_yan_gorsel-edited.png 401w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><figcaption>Tek bir \u0130nsan B\u00fcy\u00fcme Hormonu(hGH) molek\u00fcl\u00fc Yap\u0131s\u0131<br>PDB: <a href=\"https:\/\/www.rcsb.org\/structure\/1HGU\">1HGU<\/a><br><strong>DOI:&nbsp;<\/strong><a href=\"http:\/\/doi.org\/10.2210\/pdb1HGU\/pdb\" target=\"_blank\" rel=\"noreferrer noopener\">10.2210\/pdb1HGU\/pdb<\/a><\/figcaption><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Her iki hGHbp alan\u0131, <strong>insan b\u00fcy\u00fcme hormonu<\/strong> (<strong>hGH)<\/strong> ba\u011flanmas\u0131na kat\u0131lan kal\u0131nt\u0131lara katk\u0131da bulunur. Komplekste her iki resept\u00f6r, hGH \u00fczerindeki iki ba\u011flanma b\u00f6lgesinin yap\u0131sal benzerli\u011fe sahiptir. Ancak hormonla etkile\u015fime girmek i\u00e7in esasen ayn\u0131 kal\u0131nt\u0131lar\u0131 kullan\u0131r. Genel olarak, hormon-resept\u00f6r aray\u00fczleri, \u00f6nceki mutasyonel analizlerle belirlenenlerle e\u015fle\u015fir. Hormon resept\u00f6r aray\u00fczlerine ek olarak, resept\u00f6rlerin karboksil terminal alanlar\u0131 aras\u0131nda \u00f6nemli bir temas y\u00fczeyi de vard\u0131r. Temas alanlar\u0131n\u0131n g\u00f6receli kapsamlar\u0131, sinyal transd\u00fcksiyonu i\u00e7in \u00f6nemli olabilecek s\u0131ral\u0131 bir dimerizasyon mekanizmas\u0131n\u0131 destekler.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">B\u00fcy\u00fcme Hormonu Nas\u0131l Salg\u0131lan\u0131r? Nas\u0131l Etki G\u00f6sterir?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u00d6n hipofizin bir\u00e7ok hormonu, etkiyi esas olarak di\u011fer b\u00fcy\u00fck endokrin bezleri \u00fczerinde uygulayarak v\u00fccudu dolayl\u0131 olarak uyar\u0131r ve bu bezlerin ama\u00e7lanan mesaj\u0131 hedef dokuya ta\u015f\u0131yan hormonlar\u0131 salmas\u0131na neden olur. B\u00fcy\u00fcme hormonu, v\u00fccudun hemen hemen t\u00fcm dokular\u0131n\u0131 do\u011frudan uyaran \u00f6n hipofizin bir hormonu oldu\u011fu i\u00e7in benzersizdir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>B\u00fcy\u00fcme hormonu(hGH)<\/strong> etkisini ayd\u0131nlatmak i\u00e7in yap\u0131lan bir deneyde, ayn\u0131 standartlarda olan on fare se\u00e7ildi. Be\u015f s\u0131\u00e7ana g\u00fcnl\u00fck<strong> b\u00fcy\u00fcme hormonu <\/strong>enjeksiyonlar\u0131 yap\u0131l\u0131rken di\u011fer be\u015f s\u0131\u00e7ana kontrol yap\u0131ld\u0131. Deneysel pop\u00fclasyonun ya\u015fam s\u00fcresi boyunca <strong>v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131n\u0131n artmas\u0131yla kan\u0131tlanan h\u0131zlanm\u0131\u015f b\u00fcy\u00fcme<\/strong> g\u00f6r\u00fcld\u00fc. <strong>V\u00fccut kitle indeksi (BMI) \u00f6l\u00e7\u00fcmleri, erken evrelerde doku b\u00fcy\u00fcmesinin e\u015fit oranda h\u0131zland\u0131\u011f\u0131n\u0131 ortaya koydu<\/strong>. Bununla birlikte, cinsel olgunluk ya\u015f\u0131na ula\u015ft\u0131ktan sonra, yumu\u015fak dokuda b\u00fcy\u00fcme devam etti, ancak yo\u011fun kemik b\u00fcy\u00fcmesinde belirgin bir d\u00fc\u015f\u00fc\u015f g\u00f6r\u00fcld\u00fc. Bu fenomen, uzun kemiklerin epifiz plakalar\u0131n\u0131n kapanmas\u0131yla a\u00e7\u0131klanabilir.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">B\u00fcy\u00fcme Hormonu Eksikli\u011fi<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0130nsan b\u00fcy\u00fcme hormonu eksikli\u011fi genetik olarak ve hipofiz bezi ameliyatlar\u0131ndan sonra ortaya \u00e7\u0131kabilen bir durumdur. Bu durum hem yeti\u015fkin bireylerde hem de \u00e7ocuklarda b\u00fcy\u00fck bir sorun te\u015fkil eder. \u00c7ocuklarda b\u00fcy\u00fcme ve geli\u015fmenin durmas\u0131(olmamas\u0131, ge\u00e7 ba\u015flamas\u0131 gibi) bu durumun en istenmeyen \u00f6rneklerinden baz\u0131lar\u0131d\u0131r. B\u00fcy\u00fcme ve geli\u015fme \u00e7a\u011f\u0131ndaki \u00e7ocuklarda insan b\u00fcy\u00fcme hormonu(hGH) eksikli\u011fi b\u00fcy\u00fcmeyinin, h\u00fccre \u00e7o\u011falmas\u0131n\u0131n ve h\u00fccre yenilenmesinin olmamas\u0131 veya istenen seviyenin alt\u0131nda olmas\u0131na yok a\u00e7ar.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Yeti\u015fkin Bireylerde \u0130nsan B\u00fcy\u00fcme Hormonu(hGH) Eksikli\u011fi<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Plasebo kontroll\u00fc bir \u00e7al\u0131\u015fmada, <strong>b\u00fcy\u00fcme hormonu eksikli\u011fi<\/strong> olan <strong>24 yeti\u015fkin<\/strong>de alt\u0131 ayl\u0131k b\u00fcy\u00fcme hormonu replasman\u0131n\u0131n etkilerini inceledik. Hastalar\u0131n \u00e7o\u011fu, <strong>hipofiz t\u00fcm\u00f6rlerine y\u00f6nelik tedavinin bir sonucu<\/strong> olarak <strong>yeti\u015fkinlik d\u00f6neminde b\u00fcy\u00fcme hormonu eksikli\u011fine<\/strong> sahipti ve hepsi uygun tiroid, adrenal ve gonadal hormon replasman\u0131 al\u0131yordu. G\u00fcnl\u00fck rekombinant insan b\u00fcy\u00fcme hormonu (rhGH) dozu, <strong>yatmadan \u00f6nce deri alt\u0131ndan verilen v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131n\u0131n kilogram\u0131 ba\u015f\u0131na 0.07 U<\/strong> idi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0130ns\u00fclin benzeri b\u00fcy\u00fcme fakt\u00f6r\u00fc I<\/strong>&#8216;in ortalama (\u00b1 SE) plazma konsantrasyonu rhGH tedavisi s\u0131ras\u0131nda litre ba\u015f\u0131na <strong>0.41 \u00b1 0.05&#8217;ten 1.53 \u00b1 0.16 U<\/strong>&#8216;ya y\u00fckselmi\u015ftir. RhGH ile tedavinin v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 \u00fczerinde hi\u00e7bir etkisi olmam\u0131\u015ft\u0131r. <strong>B\u00fcy\u00fcme hormonu<\/strong> ile tedavi edilen grupta ortalama <strong>ya\u011fs\u0131z v\u00fccut k\u00fctlesi 5.5 \u00b1 1.1 kg (P &lt;0.0001) artm\u0131\u015f ve ya\u011f k\u00fctlesi 5.7 \u00b1 0.9 kg (P &lt;0.0001) azalm\u0131\u015ft\u0131r<\/strong>; plasebo grubunda \u00f6nemli \u00f6l\u00e7\u00fcde de\u011fi\u015fmedi. Ba\u015flang\u0131\u00e7 \u200b\u200bseviyesinde ve bir ve alt\u0131 ayl\u0131k hGH uygulamas\u0131ndan sonra \u00f6l\u00e7\u00fclen <strong>bazal metabolik h\u0131z \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131<\/strong>; ilgili de\u011ferler g\u00fcnl\u00fck ya\u011fs\u0131z v\u00fccut k\u00fctlesinin kilogram\u0131 ba\u015f\u0131na 32,4 \u00b1 1,4, 37,2 \u00b1 2,2 ve 34,4 \u00b1 1,6 kcal idi (her iki kar\u015f\u0131la\u015ft\u0131rma i\u00e7in P &lt;0,001). <strong>RhGH ile tedavi edilen grupta a\u00e7l\u0131k plazma kolesterol seviyeleri plasebo grubuna g\u00f6re daha d\u00fc\u015f\u00fckt\u00fc (P &lt;0.05), oysa plazma trigliserit de\u011ferleri \u00e7al\u0131\u015fma boyunca iki grupta benzerdi.<\/strong> \u00c7al\u0131\u015fma ile ilgili daha fazla bilgi i\u00e7in: <em><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJM198912283212605\">The Effects of Treatment with Recombinant Human Growth Hormone on Body Composition and Metabolism in Adults with Growth Hormone Deficiency<\/a><\/em><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Rekombinant DNA Teknolojisi \u0130le \u0130nsan B\u00fcy\u00fcme Hormonu(hGH)<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Son zamanlara kadar, <strong>yeti\u015fkinlikte hGH eksikli\u011finin<\/strong> fizyolojik \u00f6nemi ve olas\u0131 tedavisi hakk\u0131nda \u00e7ok az bilimsel ara\u015ft\u0131rma yap\u0131lm\u0131\u015ft\u0131r. Bunun nedeni, hayvan kaynakl\u0131 (\u00f6rn. s\u0131\u011f\u0131r veya domuz) insan <strong>b\u00fcy\u00fcme hormonu(hGH)<\/strong>&#8216;nin insanlarda etkin olmamas\u0131 ve insan kadavra GH&#8217;nin s\u0131n\u0131rl\u0131 tedarikinin hGH eksikli\u011fi olan \u00e7ocuklar\u0131n tedavisi i\u00e7in eksojen GH kullan\u0131m\u0131n\u0131 k\u0131s\u0131tlamas\u0131yd\u0131. <strong>Rekombinant insan b\u00fcy\u00fcme hormonu (rhGH)<\/strong> mevcudiyeti, hGH uygulamas\u0131 i\u00e7in daha geni\u015f endikasyonlar\u0131n ara\u015ft\u0131r\u0131lmas\u0131nda bilimsel ve klinik ilginin yenilenmesine yol a\u00e7m\u0131\u015ft\u0131r. Art\u0131k, b\u00fcy\u00fcme hormonu eksikli\u011finin panhipopituitarizmi olan eri\u015fkinlerde <strong>olumsuz metabolik etkiler yaratabilece\u011fi ve bu etkilerin rhGH ile tedavi ile geri d\u00f6nd\u00fcr\u00fclebilece\u011fi veya zay\u0131flat\u0131labilece\u011fi kabul edilmektedir<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Son zamanlarda, ilerleyen ya\u015fla birlikte, <strong>klinik hipofiz patolojisi kan\u0131t\u0131 olmayan kad\u0131n ve erkeklerin artan oran\u0131n\u0131n<\/strong>, hGH sekresyonunda ve<strong> ins\u00fclin benzeri b\u00fcy\u00fcme fakt\u00f6r\u00fc-I (IGF-I) serum seviyelerinde d\u00fc\u015f\u00fc\u015fler<\/strong> g\u00f6sterdi\u011fi de ortaya \u00e7\u0131km\u0131\u015ft\u0131r. GH eksikli\u011fi ve normal ya\u015flanman\u0131n her ikisi de <strong>protein sentezinde ve ya\u011fs\u0131z v\u00fccut ve kemik k\u00fctlesinin y\u00fczdesinde azalmalarla ve v\u00fccut ya\u011f y\u00fczdesindeki art\u0131\u015flarla ili\u015fkili oldu\u011fundan, insan b\u00fcy\u00fcme hormonu(hGH) salg\u0131s\u0131n\u0131n azalmas\u0131 ve IGF- I seviyeleri, en az\u0131ndan k\u0131smen, ya\u015flanman\u0131n yukar\u0131daki etkilerinden biri veya daha fazlas\u0131n\u0131 a\u00e7\u0131klayabilir ve baz\u0131 ya\u015fl\u0131 insanlar rhGH ile tedaviden fayda g\u00f6rebilir.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bu ba\u011flamda, son zamanlarda yap\u0131lan birka\u00e7 \u00e7al\u0131\u015fmada, birka\u00e7 haftadan 6 aya kadar de\u011fi\u015fen s\u00fcrelerde <strong>rekombinant insan b\u00fcy\u00fcme hormonu(rhGH)<\/strong> uygulamas\u0131, d\u00fc\u015f\u00fck IGF&#8217;li ya\u015fl\u0131 ki\u015filerde <strong>nitrojen dengesinde iyile\u015fmeler, ya\u011fs\u0131z v\u00fccut k\u00fctlesinde art\u0131\u015f ve v\u00fccut ya\u011f y\u00fczdesinde azalma ile sonu\u00e7lanm\u0131\u015ft\u0131r<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u0130nsan B\u00fcy\u00fcme Hormonu ve \u0130leri Ya\u015flar<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Orta ve ge\u00e7 yeti\u015fkinlikte<\/strong> t\u00fcm insanlar v\u00fccut kompozisyonunda bir dizi ilerleyici de\u011fi\u015fiklik ya\u015far. <strong>Ya\u011fs\u0131z v\u00fccut k\u00fctlesi k\u00fc\u00e7\u00fcl\u00fcr<\/strong> ve <strong>ya\u011f dokusu k\u00fctlesi geni\u015fler<\/strong>. Ya\u011fs\u0131z v\u00fccut k\u00fctlesindeki, iskelet kas\u0131, karaci\u011fer, b\u00f6brek, dalak, deri ve kemikteki atrofik s\u00fcre\u00e7leri yans\u0131t\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bu yap\u0131sal de\u011fi\u015fiklikler ya\u015flanman\u0131n ka\u00e7\u0131n\u0131lmaz sonu\u00e7lar\u0131 olarak kabul edilmi\u015ftir. Ancak yak\u0131n zamanda, <strong>ge\u00e7 yeti\u015fkinlikte b\u00fcy\u00fcme hormonunun<\/strong> bu t\u00fcr de\u011fi\u015fikliklere katk\u0131da bulunabilece\u011fi \u00f6ne s\u00fcr\u00fclm\u00fc\u015ft\u00fcr. Bu \u00f6neri iki kan\u0131ta dayanmaktad\u0131r. \u0130lk olarak, yakla\u015f\u0131k 30 ya\u015f\u0131ndan sonra, hipofiz bezi taraf\u0131ndan b\u00fcy\u00fcme hormonu salg\u0131lanmas\u0131 d\u00fc\u015fme e\u011filimindedir. <strong>B\u00fcy\u00fcme hormonu(hGH)<\/strong>, \u00e7o\u011funlukla <strong>uykunun erken saatlerinde<\/strong> olmak \u00fczere salg\u0131land\u0131\u011f\u0131ndan kandaki deri\u015fimini \u00f6l\u00e7mek zordur. -do\u011frudan maddenin salg\u0131lanmas\u0131 yerine dolayl\u0131 olarak insan b\u00fcy\u00fcme hormonu salg\u0131lanmas\u0131 s\u00f6z konusudur.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">hGH D\u00fczeylerinin Analizi<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">B\u00fcy\u00fcmeye yan\u0131t olarak karaci\u011fer ve belki de di\u011fer dokular taraf\u0131ndan \u00fcretilen ve sal\u0131nan <strong>ins\u00fclin benzeri b\u00fcy\u00fcme fakt\u00f6r\u00fc I<\/strong>&#8216;in (IGF-I, <strong>somatomedin C<\/strong> olarak da bilinir) plazma konsantrasyonu \u00f6l\u00e7\u00fclerek b\u00fcy\u00fcme hormonu deri\u015fimi analiz edilir. Plazma IGF-I konsantrasyonunda \u00e7ok az g\u00fcnl\u00fck de\u011fi\u015fim vard\u0131r ve bu nedenle bunun \u00f6l\u00e7\u00fcmleri, b\u00fcy\u00fcme hormonu salg\u0131lanmas\u0131n\u0131n uygun bir g\u00f6stergesidir. <strong>Plazma IFG-I konsantrasyonlar\u0131<\/strong>, sa\u011fl\u0131kl\u0131 yeti\u015fkinlerde ilerleyen ya\u015fla birlikte d\u00fc\u015fer. Daha az 20 ila 40 ya\u015f aras\u0131ndaki sa\u011fl\u0131kl\u0131 <strong>erkeklerin y\u00fczde 5&#8217;inden fazlas\u0131n\u0131n plazma IGF-1 de\u011ferleri litrede 350 U&#8217;dan azd\u0131r<\/strong>, ancak de\u011ferler <strong>60 ya\u015f\u0131n \u00fczerindeki sa\u011fl\u0131kl\u0131 erkeklerin y\u00fczde 30&#8217;unda bu rakam\u0131n alt\u0131ndad\u0131r<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u0130nsan B\u00fcy\u00fcme Hormonun Eksikli\u011fi ve Etkileri<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Benzer \u015fekilde, <strong>b\u00fcy\u00fcme hormonunun(hGH) gece at\u0131mlar\u0131 ya\u015f ilerledik\u00e7e k\u00fc\u00e7\u00fcl\u00fcr veya kaybolur<\/strong>. <strong>IGF-I plazma konsantrasyonu, ya\u015fl\u0131 eri\u015fkinlerde litrede 350 U&#8217;nun alt\u0131<\/strong>na d\u00fc\u015ferse, \u015fu anda mevcut radyoimm\u00fcnoassay y\u00f6ntemleriyle kendili\u011finden dola\u015fan <strong>b\u00fcy\u00fcme hormonu at\u0131mlar\u0131 tespit edilemez<\/strong>. Her iki hormonun plazma konsantrasyonlar\u0131nda e\u015fzamanl\u0131 d\u00fc\u015f\u00fc\u015f, bu g\u00f6r\u00fc\u015f\u00fcn\u00fc desteklemektedir. <strong>IGF-I&#8217;de azal\u0131\u015f b\u00fcy\u00fcme hormonu salg\u0131lanmas\u0131ndan kaynaklan\u0131r<\/strong>.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">B\u00fcy\u00fcme Hormonu Tedavisi <\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">B\u00fcy\u00fcme hormonu salg\u0131s\u0131n\u0131n azalmas\u0131na sadece plazma IGF-I konsantrasyonunda bir d\u00fc\u015f\u00fc\u015f g\u00f6stermez.<strong> Ayn\u0131 zamanda zay\u0131f v\u00fccut k\u00fctlesinin atrofisi ve k\u00fctlenin geni\u015flemesi e\u015flik eder. <\/strong>B\u00fcy\u00fcme hormonu eksikli\u011finden kaynaklanan v\u00fccut kompozisyonundaki bu de\u011fi\u015fiklikler g\u00f6zlenir. Kemirgenler, \u00e7ocuk ve 20 ila 50 ya\u015flar\u0131ndaki yeti\u015fkinlerde yap\u0131lan deneylerde g\u00f6sterildi\u011fi gibi, hormonun replasman dozlar\u0131 ile tersine \u00e7evrilebilir.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Eksiklik ve Tespitler<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Bu bulgular, zay\u0131f v\u00fccut kitlesi ve bile\u015fen organlar\u0131n\u0131n atrofisinin ve ya\u015fl\u0131lar\u0131n karakteristi\u011fi olan <strong>ya\u011f dokusu k\u00fctlesinin geni\u015flemesinin en az\u0131ndan k\u0131smen b\u00fcy\u00fcme hormonu salg\u0131s\u0131n\u0131n azalmas\u0131ndan kaynakland\u0131\u011f\u0131n\u0131 g\u00f6stermektedir<\/strong>. \u00d6yleyse, v\u00fccut kompozisyonundaki ilgili de\u011fi\u015fiklikler, \u015fimdi biyosentetik bir \u00fcr\u00fcn olarak kolayca bulunabilen <strong>rekombinant insan b\u00fcy\u00fcme hormonunun(hGH) uygulanmas\u0131yla k\u0131smen d\u00fczeltilebilir olmal\u0131d\u0131r<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0130lerleyen ya\u015fla birlikte b\u00fcy\u00fcme hormonu-ins\u00fclin benzeri b\u00fcy\u00fcme fakt\u00f6r\u00fc I (IGF-I)<\/strong> ekseninin azalan aktivitesi, ya\u011fs\u0131z v\u00fccut k\u00fctlesinin azalmas\u0131na ve ya\u015flanma ile olu\u015fan ya\u011f dokusu k\u00fctlesinin artmas\u0131na katk\u0131da bulunabilir.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u0130nsan B\u00fcy\u00fcme Hormonu(hGH) ve Klinik \u00c7al\u0131\u015fmalar<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Yap\u0131lan bir \u00e7al\u0131\u015fmada hipotezi test etmek i\u00e7in, alt\u0131 ayl\u0131k bir ba\u015flang\u0131\u00e7 \u200b\u200bd\u00f6neminde ve bunu takip eden alt\u0131 ayl\u0131k bir tedavi d\u00f6neminde plazma IGF-I konsantrasyonlar\u0131 litre ba\u015f\u0131na 350 U&#8217;dan az olan <strong>61 ila 81 ya\u015flar\u0131 aras\u0131nda<\/strong> 21 sa\u011fl\u0131kl\u0131 erkek \u00fczerinde \u00e7al\u0131\u015f\u0131ld\u0131\u011f\u0131 rapor edilmi\u015ftir. Tedavi s\u00fcresi boyunca, 12 erkek (grup 1) haftada \u00fc\u00e7 kez deri alt\u0131ndan <strong>v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131n\u0131n kilogram\u0131 ba\u015f\u0131na yakla\u015f\u0131k 0.03 mg rekombinant insan b\u00fcy\u00fcme hormonu ald\u0131<\/strong> ve 9 erkek (grup 2) tedavi g\u00f6rmedi. Plazma IGF-I seviyeleri ayl\u0131k olarak \u00f6l\u00e7\u00fcld\u00fc.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Her d\u00f6nemin sonunda, dokuz b\u00f6lgede zay\u0131f v\u00fccut k\u00fctlesi, ya\u011f dokusu k\u00fctlesi, <strong>deri kal\u0131nl\u0131\u011f\u0131<\/strong> (epidermis art\u0131 dermis) ve kemik yo\u011funlu\u011fu \u00f6l\u00e7\u00fcld\u00fc. Grup 1&#8217;de ortalama plazma IGF-I seviyesi tedavi s\u0131ras\u0131nda litre ba\u015f\u0131na 500 ila 1500 U gibi geni\u015f bir aral\u0131kta y\u00fckselmi\u015ftir. Grup 2&#8217;de ise litre ba\u015f\u0131na 350 U&#8217;nun alt\u0131nda kald\u0131.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Grup 1&#8217;de alt\u0131 ay boyunca insan b\u00fcy\u00fcme hormonu uygulamas\u0131na, ya\u011fs\u0131z v\u00fccut k\u00fctlesinde y\u00fczde 8,8&#8217;lik bir art\u0131\u015f<\/strong>, <strong>ya\u011f dokusu k\u00fctlesinde y\u00fczde 14,4&#8217;l\u00fck bir azalma ve ortalama lomber vertebral kemik yo\u011funlu\u011funda y\u00fczde 1,6&#8217;l\u0131k bir art\u0131\u015f e\u015flik etti.<\/strong> (P \u200b\u200b&lt;0,05 in\u00e7 her \u00f6rnek). Deri kal\u0131nl\u0131\u011f\u0131 y\u00fczde 7,1 artt\u0131 (P = 0,07). Yar\u0131\u00e7ap\u0131n veya proksimal femurun <strong>kemik yo\u011funlu\u011funda \u00f6nemli bir de\u011fi\u015fiklik yoktu<\/strong>. <strong>Grup 2&#8217;de tedavi s\u0131ras\u0131nda ya\u011fs\u0131z v\u00fccut k\u00fctlesi, ya\u011f dokusu k\u00fctlesi, deri kal\u0131nl\u0131\u011f\u0131 veya kemik yo\u011funlu\u011funda \u00f6nemli bir de\u011fi\u015fiklik yoktu<\/strong>.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Yeti\u015fkin Bireylerde B\u00fcy\u00fcme Hormonu &#8211; Sonu\u00e7<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">B\u00fcy\u00fcme hormonu salg\u0131s\u0131n\u0131n azalmas\u0131, k\u0131smen ya\u011fs\u0131z v\u00fccut k\u00fctlesinin azalmas\u0131ndan, ya\u011f dokusu k\u00fctlesinin geni\u015flemesinden ve ya\u015fl\u0131l\u0131kta ortaya \u00e7\u0131kan cildin incelmesinden sorumludur.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Akromegali &#8211; B\u00fcy\u00fcme Hormonun Fazla Olmas\u0131<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Hipofiz t\u00fcm\u00f6rleri<\/strong>, birincil kafa i\u00e7i neoplazilerinin yakla\u015f\u0131k% 15&#8217;ini olu\u015fturur. <strong>Hormon salg\u0131layan hipofiz h\u00fccrelerinin \u00e7o\u011falmas\u0131<\/strong>, bir dizi endokrin semptomlara neden olabilir. Hipofiz somatotrof h\u00fccrelerinden kaynaklanan t\u00fcm\u00f6rler, <strong>anormal b\u00fcy\u00fcme hormonu salg\u0131lanmas\u0131na<\/strong> ve akromegalinin ay\u0131rt edici \u00f6zelliklerine yol a\u00e7ar.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"388\" height=\"563\" src=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hgh_etki_mekanizmasi_ve_akromegali-1.jpg\" alt=\"\" class=\"wp-image-6951\" srcset=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hgh_etki_mekanizmasi_ve_akromegali-1-207x300.jpg 207w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/hgh_etki_mekanizmasi_ve_akromegali-1.jpg 388w\" sizes=\"(max-width: 388px) 100vw, 388px\" \/><figcaption>hGH biyokimyas\u0131 ve mekanizma. Kaynak: <a href=\"https:\/\/0210l2plo-y-https-doi-org.proxy.elibrary.atauni.edu.tr\/10.1016\/B978-0-12-804169-7.00015-5\">Chapter 15&nbsp;&#8211;&nbsp;Acromegaly<\/a><\/figcaption><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Akromegali<\/strong> ve <strong>insan b\u00fcy\u00fcme hormonu <\/strong>salg\u0131lanmas\u0131n\u0131n zamana g\u00f6re de\u011fi\u015fimi. G\u00f6r\u00fcld\u00fc\u011f\u00fc gibi akromegali hastal\u0131\u011f\u0131nda b\u00fcy\u00fcme hormonu sal\u0131n\u0131m\u0131 her zaman \u00fcst seviyelerde kalmaktad\u0131r. Normal bir b\u00fcy\u00fcme hormonu sal\u0131n\u0131m\u0131 ile akromegali hastas\u0131 bir insan\u0131n b\u00fcy\u00fcme hormonu sal\u0131n\u0131m\u0131n\u0131 k\u0131yaslarsak hastal\u0131\u011f\u0131n nas\u0131l geli\u015fti\u011fi ve nedeni a\u00e7\u0131k\u00e7a ortadad\u0131r. Normal bir insan\u0131n <strong>b\u00fcy\u00fcme hormonu salg\u0131lamas\u0131 \u00f6zellikle gece saatlerindedir<\/strong>. \u00d6zellikle uykunun ilk evrelerinde b\u00fcy\u00fcme hormonu salg\u0131lanmas\u0131 artmaktad\u0131r. Akromegali hastalar\u0131nda ise bu durum g\u00fcn\u00fcn her saati <strong>insan b\u00fcy\u00fcme hormonu(hGH) <\/strong>&#8216;nun y\u00fcksek seviyelerde salg\u0131lanmas\u0131 ile kendini g\u00f6stermektedir.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Akromegali Belirtileri ve Tedavi<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">1963&#8217;ten itibaren 20 y\u0131ll\u0131k bir d\u00f6nem boyunca g\u00f6r\u00fclen 256 akromegali \/ devlik vakas\u0131ndan olu\u015fan ki\u015fisel bir dizi veri litarat\u00fcrde bulunmaktad\u0131r(<a href=\"https:\/\/doi.org\/10.1111\/j.1365-2265.1987.tb00805.x\">ACROMEGALY<\/a>). Durumun sinsi do\u011fas\u0131, genellikle bir doktor taraf\u0131ndan hastay\u0131 ilgisiz bir sorun i\u00e7in g\u00f6r\u00fcrken yap\u0131lan tan\u0131da gecikmeye neden olabilir. Genellikle tan\u0131 konulmas\u0131na yol a\u00e7an di\u011fer \u00f6zellikler <strong>ba\u015f a\u011fr\u0131s\u0131<\/strong>, <strong>g\u00f6r\u00fcn\u00fcmde de\u011fi\u015fiklik<\/strong>, <strong>karpal t\u00fcnel sendromu<\/strong>, <strong>amenore<\/strong> ve <strong>diyabettir<\/strong>. Hipofiz t\u00fcm\u00f6r\u00fcn\u00fcn radyolojik g\u00f6r\u00fcn\u00fcm\u00fcn\u00fc derecelendirmek i\u00e7in Hardy sistemi ad\u0131verilen analiz methodu kullan\u0131labilir. Daha gen\u00e7 ya\u015fta ve y\u00fcksek hGH seviyelerine sahip hastalarda g\u00f6r\u00fclme e\u011filimindeydi. \u00c7e\u015fitli semptomlar\u0131n ve klinik \u00f6zelliklerin ortaya \u00e7\u0131kmas\u0131 ve hGH seviyesinin normale d\u00fc\u015f\u00fcr\u00fclmesinden kaynaklanan de\u011fi\u015fiklikler m\u00fcmk\u00fcnd\u00fcr.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"618\" height=\"556\" src=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/akromegali-gorsel.jpg\" alt=\"\" class=\"wp-image-6949\" srcset=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/akromegali-gorsel-300x270.jpg 300w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/akromegali-gorsel-500x450.jpg 500w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/akromegali-gorsel-550x495.jpg 550w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/akromegali-gorsel.jpg 618w\" sizes=\"(max-width: 618px) 100vw, 618px\" \/><figcaption>Akromegali belirtileri ayr\u0131nt\u0131l\u0131 g\u00f6zlemler. Kaynak: <a href=\"https:\/\/0210l2plo-y-https-doi-org.proxy.elibrary.atauni.edu.tr\/10.1016\/B978-0-12-804169-7.00015-5\">Chapter 15&nbsp;&#8211;&nbsp;Acromegaly<\/a><\/figcaption><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Hipertansiyon insidans\u0131 artar ve ba\u015far\u0131l\u0131 tedavinin ard\u0131ndan kan bas\u0131nc\u0131 d\u00fc\u015febilir. \u00dcst ve alt solunum yolu \u00fczerindeki etkilerin yan\u0131 s\u0131ra <strong>uyku apnesi<\/strong> ve<strong> anesteziyle ili\u015fkili problemler<\/strong> de rapor edilmektedir. Deri belirtileri aras\u0131nda <strong>terleme, pigmentli deri etiketleri, akantozis nigricans ve cutis verticis gyrata<\/strong> vard\u0131. \u0130skelet sisteminde \u00f6zellikle kal\u00e7ada <strong>kifoskolyoz ve osteoartrit<\/strong> g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131 bildirilmektedir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0130nsan b\u00fcy\u00fcme hormonu(hGH) ile ilgili yap\u0131lan klinik \u00e7al\u0131\u015fmalardan baz\u0131lar\u0131nda: <strong>Akromegali<\/strong> tedavi edildi\u011finde \u00e7o\u011fu vakada<strong> diabetes mellitus<\/strong> kaybolmaktad\u0131r. Ancak kad\u0131nlarda de\u011fil, <strong>kolloid nod\u00fcler guatr insidans\u0131 orta ya\u015fl\u0131 kad\u0131nlarda  artm\u0131\u015ft\u0131r<\/strong>. Akromegali hastalar\u0131nda <strong>hiperkalsemi<\/strong> mevcut olabilmektedir, ancak nedeni belirlenememektedir. Gen\u00e7 kad\u0131nlarda yayg\u0131n olarak g\u00f6r\u00fclen <strong>amenore<\/strong> g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131 vard\u0131r, her zaman <strong>hiperprolaktinemi<\/strong> ile ili\u015fkili olmaya bilir ve s\u0131kl\u0131kla <strong>akromegali<\/strong>nin <strong>ba\u015far\u0131l\u0131 tedavisine yan\u0131t verilmektedir<\/strong>. <strong>Akromegali<\/strong>nin <strong>hirsutizm ve galaktore ile ili\u015fkisi do\u011frulanm\u0131\u015ft\u0131r<\/strong>. <strong>Erkeklerde iktidars\u0131zl\u0131k ve libido kayb\u0131 insidans\u0131 tart\u0131\u015f\u0131lmaktad\u0131r<\/strong>: Akromegali iyile\u015ftirilenlerin bir k\u0131sm\u0131nda kaybedilen g\u00fc\u00e7 geri d\u00f6nd\u00fc, ancak <strong>depresyon meydana geldi ve psikojenik iktidars\u0131zl\u0131k oldu\u011funa inan\u0131lan \u015fey devam etti<\/strong>. <strong>Prolaktin d\u00fczeyi \u00f6l\u00e7\u00fclen 151 aktif akromegali hastas\u0131n\u0131n 49&#8217;unda hiperprolaktinemi saptand\u0131<\/strong>. Bu \u00e7al\u0131\u015fma ile ilgili daha \u00e7ok veri i\u00e7in: <a href=\"https:\/\/doi.org\/10.1111\/j.1365-2265.1987.tb00805.x\">ACROMEGALY<\/a> makalesini inceleyebilirsiniz. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>hGH yani insan b\u00fcy\u00fcme hormonu(DOI:&nbsp;10.2210\/pdb1HGU\/pdb) ile ilgili \u00e7al\u0131\u015fmalar 100 y\u0131ldan  [&#8230;]<\/p>\n","protected":false},"author":1,"featured_media":6944,"comment_status":"open","ping_status":"open","sticky":false,"template":"single-hero-cover.php","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[122],"tags":[172,175,170,171,152,125,143,106,169,173,174],"class_list":["post-6937","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-molekul","tag-akromegali","tag-buyume-hormonu","tag-buyume-ve-gelisim","tag-hgh","tag-hormon","tag-ilac","tag-ilac-gelistirme","tag-ilac-kesfi","tag-insan-buyume-hormonu","tag-rekombinant-dna","tag-rhgh"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/6937","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6937"}],"version-history":[{"count":0,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/6937\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/media\/6944"}],"wp:attachment":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6937"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6937"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6937"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}