{"id":7196,"date":"2020-10-25T21:41:09","date_gmt":"2020-10-25T18:41:09","guid":{"rendered":"https:\/\/www.ortaakarsu.net\/?p=7196"},"modified":"2025-04-20T17:16:55","modified_gmt":"2025-04-20T14:16:55","slug":"plaquenil-yan-etkileri-nelerdir","status":"publish","type":"post","link":"https:\/\/www.ortaakarsu.net\/?p=7196","title":{"rendered":"Plaquenil Yan Etkileri Nelerdir?"},"content":{"rendered":"\n<p class=\"eplus-RgBG86 wp-block-paragraph\">Covid-19 salg\u0131n\u0131 ile birlikte s\u0131k\u00e7a kullan\u0131lmaya ba\u015flayan <strong>plaquenil<\/strong>, yani <strong>hidroksiklorokin<\/strong> her ila\u00e7 gibi belirli <strong>yan etkiler<\/strong> bar\u0131nd\u0131rmaktad\u0131r. Plaquenil bir s\u0131tma ilac\u0131d\u0131r. Ve ilk kullan\u0131m alan\u0131 s\u0131tma tedavisi olmu\u015ftur. <strong>Covid19<\/strong> salg\u0131n\u0131n patlak vermesiyle <strong>FDA onayl\u0131 ila\u00e7lar\u0131n yeniden ama\u00e7land\u0131r\u0131lmas\u0131<\/strong> h\u0131zl\u0131ca bir tedavi prosed\u00fcr\u00fc geli\u015ftirmesi g\u00fcndeme gelmi\u015ftir. Bu \u00e7er\u00e7evede ba\u015fta hesaplamal\u0131 kimya \u00e7al\u0131\u015fmalar\u0131 ile ba\u015flayan s\u00fcre\u00e7 <strong>in vitro ve in vivo<\/strong> \u00e7al\u0131\u015fmalarla devam etmi\u015ftir. Etmektedir. <strong>Plaquenil yan etkileri<\/strong> bak\u0131m\u0131ndan inceldi\u011finde kar\u015f\u0131m\u0131za a\u015fa\u011f\u0131daki sonu\u00e7lar \u00e7\u0131kmaktad\u0131r.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large  eplus-JS7mo5\"><img decoding=\"async\" width=\"1024\" height=\"384\" src=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/prequenil-1024x384.png\" alt=\"Plaquenil yan etkileri nelerdir\" class=\"wp-image-7198\" srcset=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/prequenil-300x113.png 300w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/prequenil-500x188.png 500w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/prequenil-550x206.png 550w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/prequenil-700x263.png 700w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/prequenil-768x288.png 768w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/prequenil-1024x384.png 1024w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/prequenil.png 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption>Plaquenil Yan Etkileri Nelerdir?<\/figcaption><\/figure>\n\n\n\n<h2 class=\"eplus-bS6DDj wp-block-heading\">Plaquenil Yan Etkileri<\/h2>\n\n\n\n<p class=\"eplus-nwG6Bq wp-block-paragraph\"><strong>Klorokin ve Plaquenil yan etkileri ile ilgili kesin bilgi<\/strong>, terap\u00f6tik etkilerinden daha iyi yararlan\u0131lmas\u0131na olanak tan\u0131r. Klorokin i\u00e7in g\u00fcnl\u00fck maksimum 3.5-4 mg \/ kg ideal v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 ve <strong>hidroksiklorokin i\u00e7in 6-6.5 mg \/ kg ideal v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 dozu g\u00f6zlemlenerek retinopatiden ka\u00e7\u0131n\u0131labilir<\/strong>. Bu \u015fekilde her ikisi de uzun s\u00fcreli tedavi i\u00e7in kullan\u0131labilir. Klorokinin farmakokineti\u011fi, \u00f6zellikle daha <strong>y\u00fcksek dozlarda, b\u00f6brek veya karaci\u011fer yetmezli\u011fi varl\u0131\u011f\u0131nda birikebilece\u011fi anlam\u0131na gelir<\/strong>. <strong>Y\u00fcksek plazma konsantrasyonu, terap\u00f6tik etkileri g\u00fc\u00e7lendirmeden yan etkileri g\u00fc\u00e7lendirir<\/strong>.<\/p>\n\n\n\n<p class=\"eplus-c4rage wp-block-paragraph\"><strong>Hidroksiklorokin yan etkileri s\u00fcbjektif semptomlar\u0131n<\/strong> (\u00f6r. <strong>Anoreksi, ishal, bulant\u0131<\/strong>) yan\u0131 s\u0131ra, a\u015fa\u011f\u0131daki istenmeyen reaksiyonlar da \u00f6nemlidir. <\/p>\n\n\n\n<ol class=\"eplus-apsUom wp-block-list\"><li><strong>Deride ekzantem, hiperpigmentasyon ve fotodinamik reaksiyonlar<\/strong> geli\u015febilir.<\/li><li>Sar\u0131 sa\u00e7l\u0131 ve k\u0131z\u0131l sa\u00e7l\u0131 erkeklerde sa\u00e7 beyazla\u015fabilir.<\/li><li><strong>G\u00f6zde retinopatinin yan\u0131 s\u0131ra korneada klorokin birikimi<\/strong> ve akomodasyon bozukluklar\u0131 ortaya \u00e7\u0131kabilir.<\/li><li><strong>N\u00f6romiyopati ve merkezi sinir sistemi bozukluklar\u0131<\/strong> (\u00f6rn. <strong>Psikoz<\/strong>), i\u015fitme fonksiyonunun veya kan h\u00fccrelerinin bozulmas\u0131 nadir de olsa <strong>plaquenil yan etkileri<\/strong> aras\u0131ndad\u0131r.<\/li><li><strong>Hamilelik s\u0131ras\u0131nda potansiyel fetal hasar riski vard\u0131r (i\u015fitme kayb\u0131, k\u00fcrtaj).<\/strong> Bu yan etki ba\u015fka bir Covid-19 ilac\u0131 olan <strong>favicovir yan etkileri<\/strong> aras\u0131nda da g\u00f6r\u00fclmektedir. Ayr\u0131nt\u0131l\u0131 bilgi i\u00e7in <a href=\"https:\/\/www.ortaakarsu.net\/?p=6628\">Favicovir Yan Etkileri ve Favicovir Kullananlar<\/a> adl\u0131 yaz\u0131y\u0131 okuyabilirsiniz.<\/li><li>Akut doz a\u015f\u0131m\u0131 son derece tehlikelidir: <strong>\u00f6l\u00fcmc\u00fcl doz \u00e7ocuklar i\u00e7in 1 g ve yeti\u015fkinler i\u00e7in 4 g&#8217;d\u0131r<\/strong>. Plaquenil yan etkileri ile ilgili kaynak: <a href=\"https:\/\/europepmc.org\/article\/med\/2055762\">Chloroquine and hydroxychloroquine: side effect profile of important therapeutic drugs<\/a><\/li><\/ol>\n\n\n\n<script async=\"\" src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\n<ins class=\"adsbygoogle\" style=\"display:block; text-align:center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-7050495227290123\" data-ad-slot=\"7546700410\"><\/ins>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script>\n\n\n\n<h2 class=\"eplus-zkAe05 wp-block-heading\">Di\u011fer \u0130la\u00e7lar ile Birlikte Kullan\u0131m\u0131<\/h2>\n\n\n\n<p class=\"eplus-zoHQR9 wp-block-paragraph\">COVID-19&#8217;u tedavi etmek i\u00e7in potansiyel ila\u00e7lar aras\u0131nda, <strong>Klorokin<\/strong>, <strong>Hidroksiklorokin<\/strong>, <strong>Azitromisin<\/strong>, <a href=\"https:\/\/www.ortaakarsu.net\/?p=7148\">Remdesivir<\/a> gibi eski ila\u00e7lar\u0131n antiviral tedavi olarak kullan\u0131lmak \u00fczere yeniden ama\u00e7land\u0131r\u0131lmas\u0131 ilgin\u00e7 bir stratejidir. \u00c7\u00fcnk\u00fc bunlar\u0131n etki bi\u00e7imleri, g\u00fcvenlik profilleri, <strong>yan etkileri<\/strong>, dozajlar\u0131 ve <strong>etkile\u015fimleri hakk\u0131nda bilgi di\u011fer biyolojik molek\u00fcller ile iyi bilinmektedir<\/strong>. Kaynak: <a rel=\"noreferrer noopener\" href=\"https:\/\/0210l2rm3-y-https-doi-org.proxy.elibrary.atauni.edu.tr\/10.1016\/j.heliyon.2020.e04647\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.heliyon.2020.e04647<\/a> Yeniden ama\u00e7land\u0131r\u0131lan ila\u00e7lar\u0131n nas\u0131l belirlendi\u011fini \u00f6\u011frenmek i\u00e7in <a href=\"https:\/\/www.ortaakarsu.net\/?p=6409\">Molek\u00fcler Docking ve \u0130la\u00e7 Tasar\u0131m\u0131nda Kullan\u0131m\u0131<\/a> adl\u0131 yaz\u0131y\u0131 okuyabilirsiniz.<\/p>\n\n\n\n<p class=\"eplus-o2IaxV wp-block-paragraph\">Plaquenil, <strong>4-aminokinolinden t\u00fcretilen bir ila\u00e7t\u0131r<\/strong>. \u0130kinci D\u00fcnya Sava\u015f\u0131&#8217;ndan beri <strong>s\u0131tma ilac\u0131<\/strong> olarak kullan\u0131lmaktad\u0131r. Benzer bir \u00e7al\u0131\u015fma <a href=\"https:\/\/www.ortaakarsu.net\/?p=7039\">Antimalaryal \u0130la\u00e7lar \u2013 Yap\u0131 Bazl\u0131 \u0130la\u00e7 Tasar\u0131m\u0131<\/a> yaz\u0131s\u0131nda anlat\u0131lmaktad\u0131r. Lupus eritematozus, romatoid artrit ve di\u011fer enflamatuar, cilt hastal\u0131klar\u0131n\u0131n tedavisinde de yayg\u0131n olarak kullan\u0131lmaktad\u0131r. Kaynaklar: <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00417-012-2256-5\">1<\/a>,<a href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs10067-013-2226-2\">2<\/a>,<a href=\"http:\/\/eyerounds.org\/cases\/139-plaquenil-toxicity.htm\">3<\/a>,<a href=\"https:\/\/doi.org\/10.1590\/S0004-27492007000600033\">4<\/a>,<a href=\"https:\/\/doi.org\/10.1016\/0002-9394(67)92518-4\">5<\/a><\/p>\n\n\n\n<script async=\"\" src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\n<ins class=\"adsbygoogle\" style=\"display:block; text-align:center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-7050495227290123\" data-ad-slot=\"7546700410\"><\/ins>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script>\n\n\n\n<h2 class=\"eplus-as3VG1 wp-block-heading\">Plaquenil Yan Etkileri Yangi Organlar\u0131 Etkiler?<\/h2>\n\n\n\n<p class=\"eplus-dzBMRq wp-block-paragraph\"><strong>Plaquenil Yan Etkileri<\/strong>, <strong>karaci\u011fer, dalak, akci\u011ferler ve b\u00f6brekler gibi organlarda birikerek ba\u011f\u0131rsak taraf\u0131ndan h\u0131zla emilir<\/strong>. K\u0131smen karaci\u011ferde aktif metabolitlere d\u00f6n\u00fc\u015f\u00fcr ve yutuldu\u011funda \u00f6ncelikle b\u00f6brekler yoluyla at\u0131l\u0131r. Kaynak: <a href=\"https:\/\/doi.org\/10.1016\/S0889-857X(05)70150-2\">GEROPHARMACOLOGY FOR THE RHEUMATOLOGIST<\/a><\/p>\n\n\n\n<script async=\"\" src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\n<ins class=\"adsbygoogle\" style=\"display:block; text-align:center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-7050495227290123\" data-ad-slot=\"7546700410\"><\/ins>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script>\n\n\n\n<p class=\"eplus-NjeIy4 wp-block-paragraph\">Literat\u00fcre g\u00f6re [<a href=\"http:\/\/eyerounds.org\/cases\/139-plaquenil-toxicity.htm\">6<\/a>, <a href=\"https:\/\/doi.org\/10.1590\/S0004-27492002000600009\">7<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2258132\/\">8<\/a>], <strong>baz\u0131 risk fakt\u00f6rleri<\/strong> Hidroksiklorokinin neden oldu\u011fu <strong>retinopati olas\u0131l\u0131\u011f\u0131n\u0131 art\u0131r\u0131r<\/strong>; \u00f6rne\u011fin, g\u00fcnl\u00fck dozaj, k\u00fcm\u00fclatif doz, ya\u015f ve \u00f6nceki <strong>retina hastal\u0131klar\u0131n\u0131n yan\u0131 s\u0131ra b\u00f6brek veya karaci\u011fer hastal\u0131\u011f\u0131<\/strong>. Bu nedenle, Plaquenil yan etkileri i\u00e7in; i\u00e7eren farmas\u00f6tikler, hem farmas\u00f6tik hem de biyolojik numunelerde bu ilac\u0131n tan\u0131mlanmas\u0131 ve miktar\u0131n\u0131n belirlenmesi i\u00e7in basit, h\u0131zl\u0131 ve do\u011fru analitik prosed\u00fcrlerin geli\u015ftirilmesini gerektiren s\u0131k\u0131 kalite kontrol\u00fcnden ge\u00e7melidir. Kaynak: <a href=\"https:\/\/doi.org\/10.1016\/j.heliyon.2020.e04647\">Study of the structural, chemical descriptors and optoelectronic properties of the drugs Hydroxychloroquine and Azithromycin<\/a><\/p>\n\n\n\n<h3 class=\"eplus-4vy8ii wp-block-heading\">Plaquenil ve Azitromisinin Birlikte Kullan\u0131m\u0131<\/h3>\n\n\n\n<p class=\"eplus-Tc148o wp-block-paragraph\">Frans\u0131z Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 taraf\u0131ndan onayland\u0131ktan sonra, <strong>hidroksiklorokin&#8217;in SARS-CoV-2 ile enfekte hastalar \u00fczerindeki etkisini de\u011ferlendirmeyi ama\u00e7layan bir klinik \u00e7al\u0131\u015fma y\u00fcr\u00fctm\u00fc\u015ft\u00fcr<\/strong>. Raporlar\u0131nda, bir kontrol grubuna k\u0131yasla hidroksiklorokin alan hastalardaki virolojik verilere odakland\u0131lar. Elde ettikleri sonu\u00e7lar, <strong>Hidroksiklorokin&#8217;in, COVID-19 hastalar\u0131nda viral nazofarengeal SARS-CoV-2 ta\u015f\u0131nmas\u0131n\u0131 \u00e7o\u011fu hastada sadece \u00fc\u00e7 ila alt\u0131 g\u00fcnde ortadan kald\u0131rmada etkili oldu\u011funu<\/strong> g\u00f6r\u00fcld\u00fc. Elde ettikleri sonu\u00e7lar ayn\u0131 zamanda <strong>hidroksiklorokin ve Azitromisin kombinasyonunun sinerjik bir etkisini de ortaya koydu<\/strong>.<\/p>\n\n\n\n<p class=\"eplus-mTdnjE wp-block-paragraph\">COVID-19 hastalar\u0131n\u0131n, enfeksiyonlar\u0131n\u0131 iyile\u015ftirmek ve COVID-19&#8217;un D\u00fcnyadaki yay\u0131lmas\u0131n\u0131 engellemek i\u00e7in vir\u00fcs\u00fcn di\u011fer insanlara bula\u015fmas\u0131n\u0131 s\u0131n\u0131rlamak i\u00e7in <strong>Hidroksiklorokin ve Azitromisin ile tedavi edilmesini \u00f6nerdiler<\/strong>. Ayn\u0131 \u015fekilde, bu kombinasyon \u00fczerinde daha fazla \u00e7al\u0131\u015fma yap\u0131lmas\u0131 gerekti\u011fini \u00f6ne s\u00fcrd\u00fcler. \u00c7\u00fcnk\u00fc bu t\u00fcr bir kombinasyon <strong>hem SARS-CoV-2&#8217;ye kar\u015f\u0131 bir antiviral terapi g\u00f6revi g\u00f6rebilir hem de bakteriyel s\u00fcper enfeksiyonlar\u0131 \u00f6nleyebilir<\/strong>. <strong>Klorokin analogu olan hidroksiklorokin, in vitro olarak anti-SARS-CoV aktivitesine sahip oldu\u011funu g\u00f6stermi\u015ftir<\/strong>. Kaynak: <a href=\"https:\/\/doi.org\/10.1021\/jm0601856\">Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities<\/a><\/p>\n\n\n\n<p class=\"eplus-2ZgSsa wp-block-paragraph\">Klorokin, <strong>in vitro SARA-CoV-2 b\u00fcy\u00fcmesi \u00fczerinde inhibit\u00f6r etkisi<\/strong> oldu\u011fu kan\u0131tlanm\u0131\u015f olsa da, <strong>plaquenil yan etkileri haricinde d\u00fc\u015f\u00fcn\u00fcld\u00fc\u011f\u00fcnde klinik g\u00fcvenlilik profili Klorokininkinden daha iyidir<\/strong> (uzun s\u00fcreli kullan\u0131m s\u0131ras\u0131nda) ve <strong>daha y\u00fcksek g\u00fcnl\u00fck doza izin verir<\/strong> [<a href=\"https:\/\/doi.org\/10.1016\/j.ophtha.2016.01.058\">9<\/a>] ve ila\u00e7lar\u0131n birbiri ile etkile\u015fimleriyle ilgili daha az endi\u015fe edilir. Kaynak: <a href=\"https:\/\/doi.org\/10.1093\/cid\/ciaa237\">In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)<\/a><\/p>\n\n\n\n<div class=\"wp-block-columns eplus-DiCNVU is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column ticss-25419e17 eplus-GW08Md is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Covid-19 salg\u0131n\u0131 ile birlikte s\u0131k\u00e7a kullan\u0131lmaya ba\u015flayan plaquenil, yani hidroksiklorokin  [&#8230;]<\/p>\n","protected":false},"author":1,"featured_media":7201,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[122],"tags":[217,110,133,141,221,220,135,145,104,111,92,131,136,132,218,228,227,140,219],"class_list":["post-7196","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-molekul","tag-antiviral","tag-biyokimya","tag-covid","tag-covid-ilac","tag-covid_19","tag-covid-19","tag-covid19","tag-covid19-tedavi","tag-enzim-inhibisyonu","tag-enzim-inhibitoru","tag-enzimler","tag-favicovir","tag-favicovir-yan-etkileri","tag-favipiravir","tag-favipiravir-yan-etkileri","tag-plaquenil","tag-plaquenil-yan-etkileri","tag-remdesivir","tag-yan-etki"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/7196","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7196"}],"version-history":[{"count":1,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/7196\/revisions"}],"predecessor-version":[{"id":9453,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/7196\/revisions\/9453"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/media\/7201"}],"wp:attachment":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7196"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7196"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}