{"id":7582,"date":"2021-08-16T01:17:08","date_gmt":"2021-08-15T22:17:08","guid":{"rendered":"https:\/\/www.ortaakarsu.net\/?p=7582"},"modified":"2021-10-19T23:38:28","modified_gmt":"2021-10-19T20:38:28","slug":"amoksisilin-klavulanik-asit","status":"publish","type":"post","link":"https:\/\/www.ortaakarsu.net\/?p=7582","title":{"rendered":"Amoksisilin-Klavulanik Asit Nedir?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Amoksisilin-Klavulanik Asit penisilin t\u00fcrevi, antibiyotik s\u0131n\u0131f\u0131nda bir ila\u00e7t\u0131r<\/strong>. A\u015fa\u011f\u0131da amoksisilin molek\u00fcl yap\u0131s\u0131 g\u00f6r\u00fclmektedir. Antibiyotiklerin pek \u00e7o\u011funda oldu\u011fu gibi bu ila\u00e7 da bakterinin h\u00fccre duvar\u0131n\u0131 bozarak etki eder. H\u00fcrce duvar\u0131 bozulan bakteri hayatta kalamaz. Dolay\u0131s\u0131yla da hastal\u0131k yap\u0131c\u0131 etkisi ortadan kalkar.  <strong>Amoksisilin-Klavulanik Asit<\/strong> ise bakterilerin antibiyotik direnci geli\u015ftirmeleri ile ortaya \u00e7\u0131kan bir form\u00fclosyon olarak tan\u0131mlanabilir. Form\u00fclasyondaki &#8220;<strong>klavulanik asit<\/strong>&#8221; k\u0131sm\u0131 <strong>amoksisilin molek\u00fcl\u00fcn\u00fcn tek ba\u015f\u0131na yapt\u0131\u011f\u0131 etkinin<\/strong>(bakterinin antibiyoti\u011fe diren\u00e7 geli\u015ftirmesi ile) <strong>yetersiz kalmas\u0131<\/strong> sonucu etkisini artt\u0131rmak i\u00e7in kullan\u0131lan bir bile\u015fiktir.  Klavulanik asit molek\u00fcl\u00fcn\u00fc alttaki ikinci g\u00f6rselde g\u00f6rebilirsiniz. Bu madde tek ba\u015f\u0131na \u03b2-laktamaz inhibit\u00f6r\u00fc olarak i\u015flev g\u00f6rmektedir. Yani bir enzim inhibit\u00f6r\u00fcd\u00fcr. Enzim inhibit\u00f6rlerinin nas\u0131l \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131 \u00f6\u011frenmek i\u00e7in <a href=\"https:\/\/www.ortaakarsu.net\/?p=6446\">Enzim \u0130nhibit\u00f6r\u00fc ve \u0130nhibisyon \u00c7e\u015fitleri<\/a> yaz\u0131s\u0131n\u0131 okuyabilirsiniz.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"313\" height=\"161\" src=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/amoksisilin.png\" alt=\"Amoksisilin-Klavulanik Asit molek\u00fcl\u00fc(amoksisilin)\" class=\"wp-image-7583\" srcset=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/amoksisilin-300x154.png 300w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/amoksisilin.png 313w\" sizes=\"(max-width: 313px) 100vw, 313px\" \/><figcaption>Amoksisilin-Klavulanik Asit Molek\u00fcl\u00fc(<strong>Amoksisilin<\/strong>)<\/figcaption><\/figure><\/div>\n\n\n\n<div class=\"wp-block-image is-style-default\"><figure class=\"aligncenter is-resized\"><img decoding=\"async\" src=\"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/6\/63\/Clavulanic_acid.svg\/1200px-Clavulanic_acid.svg.png\" alt=\"Klavulanik Asit molek\u00fcl\u00fc\" width=\"300\" height=\"211\"\/><figcaption>Klavulanik Asit<\/figcaption><\/figure><\/div>\n\n\n\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-7050495227290123\"\n     crossorigin=\"anonymous\"><\/script>\n<!-- Yatay_G\u00f6rnt\u00fcl\u00fc -->\n<ins class=\"adsbygoogle\"\n     style=\"display:block\"\n     data-ad-client=\"ca-pub-7050495227290123\"\n     data-ad-slot=\"6780495801\"\n     data-ad-format=\"auto\"\n     data-full-width-responsive=\"true\"><\/ins>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script>\n\n\n\n<h2 class=\"wp-block-heading\">Amoksisilin-Klavulanik Asit i\u00e7eren ila\u00e7lar ve Etkileri<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"> <strong>Amoksisilin-Klavulanik Asit<\/strong>  i\u00e7eren pek \u00e7ok antibiyotik bulunmaktad\u0131r. Bunlardan baz\u0131lar\u0131 <strong>Augmentin, Klavunat, Amoksilavin, Croxilex<\/strong> gibi ticari isimler ile sat\u0131lmaktad\u0131r. \u0130lac\u0131n geni\u015f spektrumlu olu\u015fu \u00e7e\u015fitli bakteriyel enfeksiyonlarda s\u0131kl\u0131kla ba\u015fvurulmas\u0131na neden olmaktad\u0131r. \u00c7e\u015fitli form\u00fclasyon ve  ticari isimlerle sat\u0131lan bu ila\u00e7 \u00fclkemizde sadece doktor re\u00e7ete etti\u011finde al\u0131nabilmektedir. Bakterilerin antibiyotik direnci geli\u015ftirmesine y\u00f6nelik bu uygulama mevcut ila\u00e7lar\u0131n uzun vadede kullan\u0131m\u0131n\u0131 sa\u011flamas\u0131 y\u00f6n\u00fcnden son derece yerindedir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Amoksisilin-Klavulanik Asit<\/strong> birle\u015fimi, her iki ilac\u0131n farmakokineti\u011finde, ayr\u0131 ayr\u0131 uygulanmalar\u0131na k\u0131yasla kayda de\u011fer bir de\u011fi\u015fikli\u011fe neden olmaz. Oral uygulamadan sonra, her iki bile\u015fen de yakla\u015f\u0131k 1 saat i\u00e7inde maksimum plazma konsantrasyonlar\u0131na ula\u015f\u0131r ve bu konsantrasyonlar, uygulanan dozla do\u011frudan bir ili\u015fki g\u00f6sterir. Klavulanik asidin mutlak biyoyararlan\u0131m\u0131 yakla\u015f\u0131k %60&#8217;t\u0131r. Emilim, g\u0131da, s\u00fct, ranitidin veya pirenzepin ile birlikte uygulanmas\u0131ndan etkilenmez ve antasit uygulamas\u0131ndan \u00e7ok az etkilenir, ancak simetidin her iki bile\u015fenin emilim oran\u0131n\u0131 art\u0131rabilir. Probenesid, amoksisilin plazma konsantrasyonunu artt\u0131r\u0131r, ancak klavulanik asidi artt\u0131rmaz.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Klavulanik asit<\/strong>, v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131n\u0131n yakla\u015f\u0131k %25&#8217;i kadar bir da\u011f\u0131l\u0131m hacmine sahiptir ve in vitro olarak yakla\u015f\u0131k %22 proteine \u200b\u200bba\u011fl\u0131d\u0131r. Her iki bile\u015fenin doku ve v\u00fccut s\u0131v\u0131s\u0131 da\u011f\u0131l\u0131m\u0131, genellikle antibakteriyel seviyelere ula\u015fmak i\u00e7in yeterlidir, ancak konsantrasyonlar bron\u015fiyal sekresyonlarda ve beyin omurilik s\u0131v\u0131s\u0131nda biraz d\u00fc\u015f\u00fck olabilir. Her iki bile\u015fen de plasentadan ge\u00e7er, ancak yaln\u0131zca \u00e7ok k\u00fc\u00e7\u00fck miktarlar anne s\u00fct\u00fcne ge\u00e7er.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Amoksisilin-Klavulanik Asit Yan Etkiler<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"> <strong>Amoksisilin-Klavulanik Asit<\/strong> yayg\u0131n kar\u015f\u0131la\u015f\u0131lan yan etkileri:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Mide bulant\u0131s\u0131 ve\/veya kusma<\/li><li>\u0130shal durumu<\/li><li>Y\u00fcksek dozlarda daha belirgin olmak ile beraber bulant\u0131 hissinin artmas\u0131 ve kendini hasta hissetme durumunun ortaya \u00e7\u0131kmas\u0131<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Yayg\u0131n olmayan yan etkiler:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Ba\u015f a\u011fr\u0131s\u0131 olu\u015fumu<\/li><li>Ba\u015f d\u00f6nmesi<\/li><li>Deride d\u00f6k\u00fcnt\u00fc<\/li><li>Ka\u015f\u0131nt\u0131<\/li><li>Kurde\u015fen olu\u015fumu<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u00d6NEML\u0130 NOT<\/strong>: \u0130lac\u0131 kullanmadan \u00f6nce b\u00fct\u00fcn yan etkileri prospekt\u00fcsten okuyunuz. Penisiline alerjiniz varsa ilac\u0131 kullanmay\u0131n\u0131z. Alerjiniz oldu\u011fu halde ilac\u0131 kulland\u0131ysan\u0131z ciddi alerjik reaksiyonlar g\u00f6sterebilirsiniz. <strong>Bu durumda h\u0131zl\u0131 bir \u015fekilde en yak\u0131n sa\u011fl\u0131k kurulu\u015funa ba\u015fvurun.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"video-shortcode\"><iframe title=\"Amoksisilin-Klavulanik Asit Yap\u0131s\u0131n\u0131n \u03b2-laktamaz Komplesinin \u00dc\u00e7 Boyutlu G\u00f6r\u00fcnt\u00fcs\u00fc (PDB ID: 6NVU)\" width=\"1200\" height=\"675\" src=\"https:\/\/www.youtube.com\/embed\/0emx8aBjCrw?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-7050495227290123\"\n     crossorigin=\"anonymous\"><\/script>\n<!-- Yatay_G\u00f6rnt\u00fcl\u00fc -->\n<ins class=\"adsbygoogle\"\n     style=\"display:block\"\n     data-ad-client=\"ca-pub-7050495227290123\"\n     data-ad-slot=\"6780495801\"\n     data-ad-format=\"auto\"\n     data-full-width-responsive=\"true\"><\/ins>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Amoksisilin-Klavulanik asit, \u03b2-laktamaz \u00fcreten izolatlar\u0131n \u00e7o\u011funu ilaca duyarl\u0131 hale getirerek amoksisilinin antibakteriyel spektrumunu geli\u015ftirir.<\/strong> Klinik \u00e7al\u0131\u015fmalarda, <strong>amoksisilin klavulanik asit<\/strong> klinik ve bakteriyolojik olarak tek ba\u015f\u0131na amoksisiline g\u00f6re daha \u00fcst\u00fcnd\u00fcr ve en yayg\u0131n formlar\u0131 olan yeti\u015fkinlerin ve \u00e7ocuklar\u0131n tedavisinde oral yoldan uygulanan sefalosporinler, kotrimoksazol, doksisiklin ve bakampisilin gibi di\u011fer bir\u00e7ok kar\u015f\u0131la\u015ft\u0131rmal\u0131 ajan kadar en az etkilidir. <strong>Genel uygulamada kar\u015f\u0131la\u015f\u0131lan enfeksiyonlar, yani idrar yolu enfeksiyonlar\u0131, \u00fcst ve alt solunum yolu enfeksiyonlar\u0131, kulak burun bo\u011faz enfeksiyonlar\u0131 ve deri ve yumu\u015fak doku enfeksiyonlar\u0131<\/strong>. Ayr\u0131ca komplike olmayan gonore, \u015fankroid ve jinekolojik enfeksiyonlar i\u00e7in etkili tedavi sa\u011flayabilir ve ayr\u0131ca cerrahi enfeksiyona kar\u015f\u0131 profilaktik bir ajan olarak g\u00f6rev yapabilir. Bu nedenle, \u03b2-laktamaz \u00fcretiminin <strong>amoksisilinin etkinli\u011fini s\u0131n\u0131rlad\u0131\u011f\u0131 genel uygulama ortamlar\u0131nda<\/strong>,  <strong>Amoksisilin-Klavulanik Asit<\/strong> yap\u0131s\u0131, denenmi\u015f ve kan\u0131tlanm\u0131\u015f bir birinci basamak antibakteriyel maddenin yararl\u0131l\u0131\u011f\u0131n\u0131 a\u00e7\u0131k\u00e7a geni\u015fletmi\u015ftir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kaynak: <a href=\"https:\/\/doi.org\/10.2165\/00003495-199039020-00008\">https:\/\/doi.org\/10.2165\/00003495-199039020-00008<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Amoksisilin-Klavulanik Asit penisilin t\u00fcrevi, antibiyotik s\u0131n\u0131f\u0131nda bir ila\u00e7t\u0131r. A\u015fa\u011f\u0131da amoksisilin  [&#8230;]<\/p>\n","protected":false},"author":1,"featured_media":7152,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[122],"tags":[258,259,257,110,104,92,125,106,260,219],"class_list":["post-7582","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-molekul","tag-amoksisilin","tag-amoksisilin-klavulanik-asit","tag-antibiyotik","tag-biyokimya","tag-enzim-inhibisyonu","tag-enzimler","tag-ilac","tag-ilac-kesfi","tag-klavulanik-asit","tag-yan-etki"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/7582","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7582"}],"version-history":[{"count":5,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/7582\/revisions"}],"predecessor-version":[{"id":7675,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/7582\/revisions\/7675"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/media\/7152"}],"wp:attachment":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7582"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7582"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7582"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}