{"id":7825,"date":"2022-02-07T22:40:04","date_gmt":"2022-02-07T19:40:04","guid":{"rendered":"https:\/\/www.ortaakarsu.net\/?p=7825"},"modified":"2022-02-07T23:00:50","modified_gmt":"2022-02-07T20:00:50","slug":"gonadotropin-nedir-ne-icin-kullanilir","status":"publish","type":"post","link":"https:\/\/www.ortaakarsu.net\/?p=7825","title":{"rendered":"Gonadotropin Nedir? Ne i\u00e7in Kullan\u0131l\u0131r?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u0130nsanlarda, hipotalamik-hipofiz-gonadal (HPG) ekseni \u00fcreme ve cinsel \u00f6zelliklerin ifadesi i\u00e7in kritik \u00f6neme sahiptir. HPG ekseninin merkezi d\u00fczenleyicisi, memeli hipotalamus n\u00f6ronlar\u0131 taraf\u0131ndan \u00fcretilen bir dekapeptit n\u00f6rohormonu olan <strong>gonadotropin salg\u0131lat\u0131c\u0131 hormondur (GnRH)<\/strong>. GnRH peptidi, heterotrimerik Gq protein yolu yoluyla GnRH resept\u00f6r\u00fcn\u00fc aktive edebilir. Bu da \u00fcreme hormonu sal\u0131n\u0131m\u0131n\u0131 ba\u015flat\u0131r ve gonadotropinleri serbest b\u0131rak\u0131r:<strong> folik\u00fcl uyar\u0131c\u0131 hormon<\/strong> ve <strong>l\u00fcteinize edici hormon<\/strong>.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"video-shortcode\"><iframe title=\"\u0130nsan gonadotropin salg\u0131layan hormon resept\u00f6r\u00fc GnRH1R&#039;nin yap\u0131s\u0131(PDB ID: 7BR3)\" width=\"1200\" height=\"675\" src=\"https:\/\/www.youtube.com\/embed\/Zq_msKrNol0?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><figcaption>PDB ID: 7BR3<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><strong>Gonadotropin<\/strong> salg\u0131lat\u0131c\u0131 hormon<\/strong> nab\u0131z paternindeki de\u011fi\u015fiklik, \u00fcreme bozukluklar\u0131 ile ili\u015fkili hem fizyolojik hem de patolojik ko\u015fullarda g\u00f6zlenir. \u0130nsanlarda <strong><strong>Gonadotropin<\/strong> salg\u0131lat\u0131c\u0131 hormon<\/strong> peptidinin GnRH-I ve GnRH-II olmak \u00fczere iki izoformu vard\u0131r ve etkileri rodopsin G protein-ba\u011fl\u0131 resept\u00f6re (GPCR) ait olan klasik GnRH1 resept\u00f6r\u00fcn\u00fcn (GnRH1R)aktivasyonu ile ortaya \u00e7\u0131kar. GnRH1R \u00f6ncelikle hipofiz gonadotrop h\u00fccrelerinde eksprese edilir, ayr\u0131ca lenfositler ve meme, yumurtal\u0131k ve prostat h\u00fccrelerinde eksprese edilir ve infertilite, uterin fibroidler, endometrioz ve prostat kanseri gibi durumlar\u0131n tedavisi i\u00e7in umut verici bir terap\u00f6tik hedef olarak ortaya \u00e7\u0131km\u0131\u015ft\u0131r.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.nature.com\/articles\/s41467-020-19109-w\"><img decoding=\"async\" src=\"https:\/\/media.springernature.com\/lw685\/springer-static\/image\/art%3A10.1038%2Fs41467-020-19109-w\/MediaObjects\/41467_2020_19109_Fig1_HTML.png\" alt=\"Gonadotropin ve antagonist elagolix ile kompleks halinde insan GnRH1R'nin genel yap\u0131s\u0131\"\/><\/a><figcaption><strong>Gonadotropin<\/strong> ve antagonist elagolix ile kompleks halinde insan GnRH1R&#8217;nin genel yap\u0131s\u0131<\/figcaption><\/figure>\n\n\n\n<script async=\"\" src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-7050495227290123\" crossorigin=\"anonymous\"><\/script>\n<!-- Yeni - G\u00f6r\u00fcnt\u00fcl\u00fc Reklam -->\n<ins class=\"adsbygoogle\" style=\"display:block\" data-ad-client=\"ca-pub-7050495227290123\" data-ad-slot=\"9786676947\" data-ad-format=\"auto\" data-full-width-responsive=\"true\"><\/ins>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script>\n\n\n\n<p class=\"wp-block-paragraph\">Son y\u0131llarda, <strong>gonadotropin<\/strong> \u00e7e\u015fitleri ve <a href=\"https:\/\/www.ortaakarsu.net\/?p=6805\">seks steroidleri<\/a>nin salg\u0131lanmas\u0131n\u0131 engelleyerek, gonadotrop h\u00fccrelerde kar\u015f\u0131l\u0131k gelen resept\u00f6rleri a\u015fa\u011f\u0131 reg\u00fcle eden ve duyars\u0131zla\u015ft\u0131ran klinik uygulamalar i\u00e7in bir\u00e7ok GnRH-analog agonisti geli\u015ftirilmi\u015ftir. Ayr\u0131ca GnRH1R sinyalini hemen bloke edebilen GnRH-analog antagonistleri sentezlenmi\u015ftir. Zay\u0131f stabilite ve k\u0131sa yar\u0131 \u00f6m\u00fcr dahil olmak \u00fczere peptid ila\u00e7larla ili\u015fkili problemler nedeniyle, GnRH1R \u00fczerinde etkili olan oral olarak aktif k\u00fc\u00e7\u00fck molek\u00fcll\u00fc ila\u00e7lar olduk\u00e7a arzu edilir ve baz\u0131lar\u0131 \u00fcreme hormonu ile ilgili hastal\u0131klar\u0131 tedavi etmek i\u00e7in \u00e7e\u015fitli kimyasal s\u0131n\u0131flardan potansiyel yollar olarak ortaya \u00e7\u0131km\u0131\u015ft\u0131r . \u0130lk peptit olmayan GnRH1R antagonisti, Abbott Laboratories taraf\u0131ndan rapor edilmi\u015ftir. O zamandan beri, peptit olmayan antagonistlerin \u00e7e\u015fitli yap\u0131 iskeleleri tasarlanm\u0131\u015f ve farkl\u0131 klinik deneme a\u015famalar\u0131na ba\u015far\u0131l\u0131 bir \u015fekilde ilerletilmi\u015ftir. \u00d6rne\u011fin, bir urasil t\u00fcrevi olan elagolix (NBI-56418), ABD&#8217;de Neurocrine Biosciences taraf\u0131ndan rapor edilmi\u015f ve 2018 y\u0131l\u0131nda ABD G\u0131da ve \u0130la\u00e7 Dairesi taraf\u0131ndan endometriozis ile ili\u015fkili orta-\u015fiddetli a\u011fr\u0131n\u0131n tedavisi i\u00e7in onaylanm\u0131\u015ft\u0131r. \u0130la\u00e7 ayr\u0131ca kad\u0131nlarda rahim fibroidlerinin ve erkeklerde prostat kanseri ve iyi huylu prostat hiperplazisinin tedavisi i\u00e7in geli\u015ftirilmektedir. Japonya&#8217;daki Takeda \u015eirketi, endometriozis, prostat kanseri ve rahim fibroidleri i\u00e7in denemelere giren sufugolix ve relugolix dahil olmak \u00fczere bir dizi tienopiridin t\u00fcrevi geli\u015ftirdi. \u00d6zellikle, relugolix son zamanlarda Japonya&#8217;da uterus fibroidleri ile ili\u015fkili semptomlar\u0131n tedavisi i\u00e7in pazarlanmak \u00fczere onaylanm\u0131\u015ft\u0131r. GnRH1R&#8217;nin biyokimyasal ve farmakolojik \u00f6zelliklerini anlamada son zamanlarda kaydedilen ilerlemeye ra\u011fmen, GnRH1 resept\u00f6r\u00fcn\u00fcn ligandlarla etkile\u015fiminin molek\u00fcler mekanizmalar\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131 hala deneysel bir yap\u0131 gerektirir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Kaynak: <strong>DOI:&nbsp;<\/strong><a href=\"http:\/\/dx.doi.org\/10.1038\/s41467-020-19109-w\" target=\"_blank\" rel=\"noreferrer noopener\">10.1038\/s41467-020-19109-w<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0130nsanlarda, hipotalamik-hipofiz-gonadal (HPG) ekseni \u00fcreme ve cinsel \u00f6zelliklerin ifadesi i\u00e7in  [&#8230;]<\/p>\n","protected":false},"author":1,"featured_media":7834,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[91],"tags":[110,92,292,291,125,143,106,9,293,150],"class_list":["post-7825","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-enzimler-biyokimya","tag-biyokimya","tag-enzimler","tag-folikul-uyarici-hormon","tag-gonadotropin","tag-ilac","tag-ilac-gelistirme","tag-ilac-kesfi","tag-ilac-tasarimi","tag-luteinize-edici-hormon","tag-testosteron"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/7825","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7825"}],"version-history":[{"count":8,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/7825\/revisions"}],"predecessor-version":[{"id":7833,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/7825\/revisions\/7833"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/media\/7834"}],"wp:attachment":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7825"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7825"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7825"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}