{"id":8358,"date":"2023-02-13T20:21:10","date_gmt":"2023-02-13T17:21:10","guid":{"rendered":"https:\/\/www.ortaakarsu.net\/?p=8358"},"modified":"2025-04-01T20:21:04","modified_gmt":"2025-04-01T17:21:04","slug":"cipralex","status":"publish","type":"post","link":"https:\/\/www.ortaakarsu.net\/?p=8358","title":{"rendered":"Sitalopram(Cipralex) ve Yan Etkileri"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1248px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><h2>Sitalopram(Cipralex) Nedir?<\/h2>\n<p>Sitalopram\u0131n, yani Cipralex in S-enantiyomeri olan se\u00e7ici bir serotonin geri al\u0131m inhibit\u00f6r\u00fc antidepresan olan esitalopram oksalat (S-sitalopram, Lexapro\u2122), depresyon ve anksiyete bozukluklar\u0131n\u0131n tedavisi i\u00e7in d\u00fcnya \u00e7ap\u0131nda klinik olarak geli\u015ftirilmektedir. Preklinik \u00e7al\u0131\u015fmalar, sitalopram\u0131n terap\u00f6tik aktivitesinin S-izomerinde bulundu\u011funu ve esitalopram\u0131n insan serotonin ta\u015f\u0131y\u0131c\u0131s\u0131na y\u00fcksek afinite ile ba\u011fland\u0131\u011f\u0131n\u0131 g\u00f6stermektedir. Tersine, R-sitalopram bu ta\u015f\u0131y\u0131c\u0131da essitalopramdan yakla\u015f\u0131k 30 kat daha az g\u00fc\u00e7l\u00fcd\u00fcr. Essitalopram lineer farmakokineti\u011fine sahiptir, b\u00f6ylece artan dozlarla orant\u0131l\u0131 ve \u00f6ng\u00f6r\u00fclebilir bir \u015fekilde plazma seviyeleri y\u00fckselir ve 27 \u2013 32 saatlik yar\u0131 \u00f6mr\u00fc, g\u00fcnde bir kez dozlama ile tutarl\u0131d\u0131r. Ek olarak, essitalopram\u0131n sitokrom P450 ila\u00e7 metabolize edici enzimler \u00fczerinde in vitro olarak ihmal edilebilir etkileri vard\u0131r, bu da ila\u00e7-ila\u00e7 etkile\u015fimleri i\u00e7in d\u00fc\u015f\u00fck bir potansiyel oldu\u011funu d\u00fc\u015f\u00fcnd\u00fcr\u00fcr. Essitalopram\u0131n maj\u00f6r depresif bozuklu\u011fu olan hastalarda etkilili\u011fi, \u00fc\u00e7\u00fc aktif kontrol olarak sitalopram\u0131n kullan\u0131ld\u0131\u011f\u0131 \u00e7ok say\u0131da k\u0131sa s\u00fcreli, plasebo kontroll\u00fc klinik \u00e7al\u0131\u015fmada ve ayr\u0131ca 36 haftal\u0131k bir \u00e7al\u0131\u015fmada g\u00f6sterilmi\u015ftir. Bu \u00e7al\u0131\u015fmalarda, essitalopram\u0131n(Cipralex), plaseboya g\u00f6re depresyon ve ili\u015fkili anksiyete semptomlar\u0131n\u0131n tedavisinde g\u00fc\u00e7l\u00fc bir etkinli\u011fe sahip oldu\u011fu g\u00f6sterilmi\u015ftir. Yayg\u0131n anksiyete bozuklu\u011fu, panik bozuklu\u011fu ve sosyal anksiyete bozuklu\u011funun tedavisinde de etkinlik g\u00f6sterilmi\u015ftir. Sonu\u00e7lar ayr\u0131ca kar\u015f\u0131la\u015ft\u0131r\u0131labilir dozlarda essitalopram\u0131n plasebo tedavisine sitalopramdan daha \u00f6nce klinik olarak anlaml\u0131 ve istatistiksel olarak anlaml\u0131 bir \u00fcst\u00fcnl\u00fck g\u00f6sterdi\u011fini g\u00f6stermektedir. G\u00fcvenlilik veri taban\u0131n\u0131n analizi, advers olaylar nedeniyle tedaviyi b\u0131rakma oran\u0131n\u0131n d\u00fc\u015f\u00fck oldu\u011funu g\u00f6stermektedir ve advers olaylar nedeniyle tedaviyi erken b\u0131rakan hastalar\u0131n oran\u0131nda essitalopram 10 mg\/g\u00fcn ile plasebo aras\u0131nda istatistiksel olarak anlaml\u0131 bir fark yoktur. Essitalopramla ili\u015fkili plasebodan daha y\u00fcksek bir oranda meydana gelen en yayg\u0131n yan etkiler aras\u0131nda mide bulant\u0131s\u0131, uykusuzluk, bo\u015falma bozuklu\u011fu, diyare, a\u011f\u0131z kurulu\u011fu ve uyuklama yer al\u0131r. Essitalopram ile tedavi edilen hastalar\u0131n %10'unda yaln\u0131zca mide bulant\u0131s\u0131 meydana geldi.<\/p>\n<p>Kaynak; <a href=\"https:\/\/doi.org\/10.1517\/13543784.11.10.1477\">https:\/\/doi.org\/10.1517\/13543784.11.10.1477<\/a><\/p>\n<p>Se\u00e7ici serotonin geri al\u0131m inhibit\u00f6rleri (SSRI'ler), bir\u00e7ok psikiyatrik bozuklu\u011fun tedavisinde terap\u00f6tik g\u00f6r\u00fcn\u00fcm\u00fc \u00f6nemli \u00f6l\u00e7\u00fcde de\u011fi\u015ftirmi\u015ftir. Depresyonun yan\u0131 s\u0131ra anksiyete bozukluklar\u0131n\u0131n tedavisi i\u00e7in birinci basamak tedavi olarak geni\u015f \u00e7apta kabul g\u00f6rmektedirler. SSRI'lar bir s\u0131n\u0131f olarak benzer etki mekanizmalar\u0131na sahipken, kimyasal yap\u0131, farmakolojik \u00f6zellikler (\u00f6rne\u011fin, serotonin ta\u015f\u0131y\u0131c\u0131 i\u00e7in g\u00f6reli se\u00e7icilik ve al\u0131m inhibisyonu potansiyeli), farmakokinetik profil ve ila\u00e7 etkile\u015fim potansiyeli bak\u0131m\u0131ndan farkl\u0131l\u0131k g\u00f6sterirler. Bu farkl\u0131l\u0131klar, optimal hasta y\u00f6netimi i\u00e7in uygun ila\u00e7lar\u0131n se\u00e7iminde klinik olarak \u00f6nemli olabilir. <strong>Cipralex<\/strong> de bu ila\u00e7lardan biridir.<\/p>\n<p><!-- \/wp:post-content --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p><strong>Esitalopram, yani Cipralex<\/strong> \u2014 (S)-(+)-1-[3-(dimetil-amino)propil]-1-(p-fluorofenil)-5-ftalankarbonitril oksalat \u2014 rasemik SSRI antidepresan sitalopram\u0131n (S)-enantiyomeridir. [1] Sitalopram\u0131n terap\u00f6tik etkilerine yaln\u0131zca essitalopram arac\u0131l\u0131k etti\u011fi g\u00f6sterilmi\u015ftir. <strong>Fizyolojik konsantrasyonlarda, sitalopram\u0131n yani Cipralex'in (R)-enantiyomeri, serotonin geri al\u0131m\u0131n\u0131 inhibe etmek i\u00e7in kayda de\u011fer bir aktivite g\u00f6stermez<\/strong> ve (S'nin aktivitesine kar\u015f\u0131 koyabilir. )-izomer. (R)-izomerinin ise histamin H1 resept\u00f6r\u00fc i\u00e7in zay\u0131f afiniteye sahip oldu\u011fu g\u00f6sterilmi\u015ftir. Ayr\u0131ca (R)-sitalopram\u0131n demetil metaboliti, sitokrom P450 (CYP) 2D6'y\u0131 zay\u0131f bir \u015fekilde inhibe eder. <strong>Cipralex, in vitro ba\u011flanma \u00e7al\u0131\u015fmalar\u0131nda serotonin al\u0131m\u0131n\u0131n inhibisyonunda sitalopram\u0131n iki kat\u0131ndan daha fazla etkili oldu\u011fu bulunmu\u015ftur ve s\u0131n\u0131f\u0131ndaki en se\u00e7ici ajand\u0131r<\/strong>.<\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:image  --><\/p>\n<figure class=\"wp-block-image aligncenter size-full\"><img decoding=\"async\" width=\"434\" height=\"463\" src=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/image-111.png\" alt=\"Cipralex dozlar\u0131 ve kar\u015f\u0131la\u015ft\u0131rma\" class=\"wp-image-8379\" srcset=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/image-111-200x213.png 200w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/image-111-281x300.png 281w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/image-111-400x427.png 400w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/image-111.png 434w\" sizes=\"(max-width: 434px) 100vw, 434px\" \/><figcaption class=\"wp-element-caption\">Cipralex dozlar\u0131 ve kar\u015f\u0131la\u015ft\u0131rma<\/figcaption><\/figure>\n<p><!-- \/wp:image --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>Kaynak: <a href=\"https:\/\/link.springer.com\/article\/10.2165\/00003088-200746040-00002#article-info\">https:\/\/link.springer.com\/article\/10.2165\/00003088-200746040-00002#article-info<\/a><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p><strong>Cipralex yan etkileri \u015funlard\u0131r:<\/strong><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:list --><\/p>\n<ul><!-- wp:list-item --><\/p>\n<li>Kusma, bulant\u0131(<strong>\u00f6zellikle ila\u00e7 ilk kullan\u0131lmaya ba\u015fland\u0131\u011f\u0131nda<\/strong>)<\/li>\n<p><!-- \/wp:list-item --><\/p>\n<p><!-- wp:list-item --><\/p>\n<li>\u0130shal veya kab\u0131zl\u0131k(<strong>bu etki ki\u015fiden ki\u015fiye g\u00f6re de\u011fi\u015fir<\/strong>), kar\u0131n a\u011fr\u0131s\u0131, midede yanma hissi(ac\u0131ma)<\/li>\n<p><!-- \/wp:list-item --><\/p>\n<p><!-- wp:list-item --><\/p>\n<li><strong>Terleme<\/strong>(so\u011fuk terleme veya s\u0131caklama)<\/li>\n<p><!-- \/wp:list-item --><\/p>\n<p><!-- wp:list-item --><\/p>\n<li>A\u011f\u0131z kurulu\u011fu(\u00f6zellikle doz a\u015f\u0131m\u0131nda, ila\u00e7lar\u0131n\u0131z\u0131 doktorunuzun \u00f6nerdi\u011fi dozlarda kullan\u0131n)<\/li>\n<p><!-- \/wp:list-item --><\/p>\n<p><!-- wp:list-item --><\/p>\n<li><strong>\u0130\u015ftah kayb\u0131 veya zamanla \u015fiddetli i\u015ftah(bu etkide b\u00fcy\u00fck oranda ki\u015fiden ki\u015fiye g\u00f6re de\u011fi\u015fmektedir.)<\/strong><\/li>\n<p><!-- \/wp:list-item --><\/p>\n<p><!-- wp:list-item --><\/p>\n<li>Farkl\u0131 cinsel etkiler<\/li>\n<p><!-- \/wp:list-item --><\/p>\n<p><!-- wp:list-item --><\/p>\n<li>Ba\u015f a\u011fr\u0131s\u0131<\/li>\n<p><!-- \/wp:list-item --><\/p>\n<p><!-- wp:list-item --><\/p>\n<li>\u00c7arp\u0131nt\u0131(<strong>\u00f6zellikle doz a\u015f\u0131m\u0131nda<\/strong>)<\/li>\n<p><!-- \/wp:list-item --><\/p>\n<\/ul>\n<p><!-- \/wp:list --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>Cipralex yan etkileri genlelikle ila\u00e7 kullanmaya ba\u015flad\u0131ktan bir ka\u00e7 hafta sonra ge\u00e7me e\u011filimdedir.<\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p>Bir di\u011fer antidepresan s\u0131n\u0131f\u0131ndaki ila\u00e7 olan venlafaksin hakk\u0131ndaki yaz\u0131y\u0131 okumak i\u00e7in <a href=\"https:\/\/www.ortaakarsu.net\/?p=8347\">Venlafaksin Nedir? Venlafaksin Yan Etkileri Nelerdir?<\/a> yaz\u0131s\u0131n\u0131 ziyaret edebilirsiniz. <strong>Cipralex<\/strong> de, Venlafaksin de ayn\u0131 hastal\u0131klar\u0131n tedavisinde kullan\u0131lan farkl\u0131 ila\u00e7lard\u0131r. Ba\u015fka bir antidepresan <a href=\"https:\/\/www.ortaakarsu.net\/?p=8232\">Duloksetin ve Duloksetin Yan Etkileri<\/a> Cipralex'in etkilerini anlaman\u0131zda size yard\u0131mc\u0131 olabilir.<strong> Cipralex<\/strong> ilac\u0131n\u0131n tedavi etti\u011fi hastal\u0131k olan <a href=\"https:\/\/www.ortaakarsu.net\/?p=8381\">Major Depresif Bozukluk<\/a> hakk\u0131nda daha fazla bilgi i\u00e7in yaz\u0131m\u0131z\u0131 okuyabilirsiniz.<\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":8168,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[122],"tags":[447,110,497,499,125,143,106,9,492,495,219],"class_list":["post-8358","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-molekul","tag-antidepresan","tag-biyokimya","tag-cipralex","tag-essitalopram","tag-ilac","tag-ilac-gelistirme","tag-ilac-kesfi","tag-ilac-tasarimi","tag-venlafaksin","tag-venlafaxine","tag-yan-etki"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/8358","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8358"}],"version-history":[{"count":25,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/8358\/revisions"}],"predecessor-version":[{"id":9205,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/posts\/8358\/revisions\/9205"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/media\/8168"}],"wp:attachment":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8358"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=8358"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=8358"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}