{"id":10481,"date":"2026-07-18T19:53:52","date_gmt":"2026-07-18T16:53:52","guid":{"rendered":"https:\/\/www.ortaakarsu.net\/?post_type=product&#038;p=10481"},"modified":"2026-07-18T19:56:08","modified_gmt":"2026-07-18T16:56:08","slug":"molekuler-docking-egitimi-ve-ileri-seviye-rehber-bolum-2","status":"publish","type":"product","link":"https:\/\/www.ortaakarsu.net\/?product=molekuler-docking-egitimi-ve-ileri-seviye-rehber-bolum-2","title":{"rendered":"Molek\u00fcler Docking E\u011fitimi ve \u0130leri Seviye Rehber \u2014 B\u00f6l\u00fcm 2"},"content":{"rendered":"<p class=\"PDq2pG_selectionAnchorContainer\" data-start=\"386\" data-end=\"701\"><strong data-start=\"386\" data-end=\"437\">Molek\u00fcler Docking \u0130leri Seviye Rehber \u2014 B\u00f6l\u00fcm 2<\/strong>, temel docking i\u015f ak\u0131\u015f\u0131n\u0131 bilen ara\u015ft\u0131rmac\u0131lar i\u00e7in haz\u0131rlanm\u0131\u015f 38 sayfal\u0131k uygulamal\u0131 bir e-kitapt\u0131r. Bu b\u00f6l\u00fcm, yaln\u0131zca daha fazla hesaplama \u00e7al\u0131\u015ft\u0131rmay\u0131 de\u011fil, ba\u011flanma hipotezini s\u0131n\u0131rlayan fiziksel belirsizli\u011fi tan\u0131may\u0131 ve buna uygun y\u00f6ntemi se\u00e7meyi \u00f6\u011fretir.<\/p>\n<p data-start=\"703\" data-end=\"1063\">Rijit resept\u00f6r varsay\u0131m\u0131n\u0131n yetersiz kald\u0131\u011f\u0131 durumlar\u0131; yan zincir rotamerleri, konformasyon se\u00e7imi, ind\u00fcklenmi\u015f uyum ve ensemble docking yakla\u015f\u0131mlar\u0131 \u00fczerinden ele al\u0131r. Molek\u00fcler dinamik y\u00f6r\u00fcngelerinden anlaml\u0131 resept\u00f6r konformerleri se\u00e7me, yap\u0131sal suyun, iyonlar\u0131n, kofakt\u00f6rlerin ve metal koordinasyonunun modele etkisini sorgulama konular\u0131nda yol g\u00f6sterir.<\/p>\n<p data-start=\"1065\" data-end=\"1098\">Bu rehberde \u015funlar\u0131 \u00f6\u011frenirsiniz:<\/p>\n<ul data-start=\"1100\" data-end=\"1735\">\n<li data-section-id=\"je0rwk\" data-start=\"1100\" data-end=\"1173\">Resept\u00f6r esnekli\u011finin kayna\u011f\u0131n\u0131 ve uygun modelleme d\u00fczeyini belirleme<\/li>\n<li data-section-id=\"2i8odb\" data-start=\"1174\" data-end=\"1259\">Esnek yan zincir, rotamer, soft docking ve k\u0131s\u0131tl\u0131 docking kullan\u0131m\u0131n\u0131n s\u0131n\u0131rlar\u0131<\/li>\n<li data-section-id=\"jasl6g\" data-start=\"1260\" data-end=\"1311\">Ensemble docking ve MD tabanl\u0131 konformer se\u00e7imi<\/li>\n<li data-section-id=\"1ivs4ic\" data-start=\"1312\" data-end=\"1353\">\u0130nd\u00fcklenmi\u015f uyumun do\u011fru yorumlanmas\u0131<\/li>\n<li data-section-id=\"vdp99h\" data-start=\"1354\" data-end=\"1461\">Hidrojen ba\u011f\u0131, iyonik, aromatik, halojen, hidrofobik ve metal etkile\u015fimlerinin fiziksel de\u011ferlendirmesi<\/li>\n<li data-section-id=\"mlc6ex\" data-start=\"1462\" data-end=\"1543\">Farkl\u0131 docking motorlar\u0131n\u0131n varsay\u0131mlar\u0131n\u0131 kar\u015f\u0131la\u015ft\u0131rma ve do\u011fru arac\u0131 se\u00e7me<\/li>\n<li data-section-id=\"7e1t1r\" data-start=\"1544\" data-end=\"1633\">Cross-docking, yeniden puanlama, aktif\/inaktif kontrolleri ve kan\u0131t matrisi olu\u015fturma<\/li>\n<li data-section-id=\"10ju3fo\" data-start=\"1634\" data-end=\"1735\">Tekrar \u00fcretilebilir raporlama, belirsizlik y\u00f6netimi ve bilimsel olarak savunulabilir sonu\u00e7 yaz\u0131m\u0131<\/li>\n<\/ul>\n<p data-start=\"1737\" data-end=\"2069\">Bu e-kitap, ba\u015flang\u0131\u00e7 seviyesindeki PDBQT haz\u0131rlama, arama kutusu ve temel poz okuma bilgisini varsayar; <strong data-start=\"1842\" data-end=\"1883\">Ba\u015flang\u0131\u00e7 Rehberi\u2019nin do\u011fal devam\u0131d\u0131r<\/strong>. \u0130leri hesaplama y\u00f6ntemlerinin daha g\u00fc\u00e7l\u00fc hipotezler \u00fcretebilece\u011fini, ancak tek ba\u015f\u0131na ba\u011flanma afinitesi, biyolojik etki veya g\u00fcvenlilik kan\u0131t\u0131 olu\u015fturmayaca\u011f\u0131n\u0131 a\u00e7\u0131k bi\u00e7imde vurgular.<\/p>\n<p data-start=\"1737\" data-end=\"2069\"><img decoding=\"async\" class=\"alignnone size-large wp-image-10483\" src=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/ChatGPT-Image-18-Tem-2026-19_52_39-819x1024.png\" alt=\"\" width=\"819\" height=\"1024\" srcset=\"https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/ChatGPT-Image-18-Tem-2026-19_52_39-200x250.png 200w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/ChatGPT-Image-18-Tem-2026-19_52_39-240x300.png 240w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/ChatGPT-Image-18-Tem-2026-19_52_39-400x500.png 400w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/ChatGPT-Image-18-Tem-2026-19_52_39-500x625.png 500w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/ChatGPT-Image-18-Tem-2026-19_52_39-600x750.png 600w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/ChatGPT-Image-18-Tem-2026-19_52_39-700x875.png 700w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/ChatGPT-Image-18-Tem-2026-19_52_39-768x960.png 768w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/ChatGPT-Image-18-Tem-2026-19_52_39-800x1000.png 800w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/ChatGPT-Image-18-Tem-2026-19_52_39-819x1024.png 819w, https:\/\/www.ortaakarsu.net\/wp-content\/uploads\/ChatGPT-Image-18-Tem-2026-19_52_39.png 1122w\" sizes=\"(max-width: 819px) 100vw, 819px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>B\u00f6l\u00fcm 1\u2019in temelleri \u00fczerine kurulan ileri seviye rehber; resept\u00f6r esnekli\u011fi, ensemble docking, ind\u00fcklenmi\u015f uyum, su\/metal ba\u011flam\u0131, motor se\u00e7imi ve do\u011frulama stratejileriyle docking modelinizi daha ger\u00e7ek\u00e7i ve ele\u015ftirel bi\u00e7imde kurman\u0131za yard\u0131mc\u0131 olur.<\/p>\n","protected":false},"featured_media":10482,"template":"","meta":{"_acf_changed":false},"product_brand":[740],"product_cat":[929],"product_tag":[939,938,931,932,933,930,934,936,935,937],"class_list":["post-10481","product","type-product","status-publish","has-post-thumbnail","product_brand-ortaakarsu-net","product_cat-e-kitap","product_tag-autodock","product_tag-autodock-vina","product_tag-docking","product_tag-hesaplamali-kimya","product_tag-kimya","product_tag-molekuler-docking","product_tag-organik-kimya","product_tag-protein","product_tag-protein-ligand","product_tag-tibbi-kimya","first","instock","downloadable","taxable","shipping-taxable","purchasable","product-type-simple"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/product\/10481","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=\/wp\/v2\/media\/10482"}],"wp:attachment":[{"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=10481"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_brand&post=10481"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_cat&post=10481"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.ortaakarsu.net\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_tag&post=10481"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}