Bactrim Forte (Co-trimoxazole) (Bactrim Forte Tablet) and Treprostinil: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
CYP2C8 inhibition may increase treprostinil exposure.
Clinical significance and safety
Bactrim Forte (Co-trimoxazole) and Treprostinil: Trepulmix names CYP2C8 inhibitors including trimethoprim and warns that treprostinil adjustment may be needed when an inhibitor is added or removed. In co-trimoxazole, trimethoprim is the relevant component. The specialist should assess tolerability, blood pressure and any infusion changes. Do not interrupt prescribed treatment yourself.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.