Diflucan 150 mg (Fluconazole): Uses, Safety and Interactions

Uses and product scope

Diflucan 150 mg capsules contain fluconazole, a systemic antifungal. This page uses the UK capsule information and patient leaflet. The medicine is used for susceptible fungal infections, including selected Candida infections. A 150 mg capsule can be part of treatment for genital candidiasis, but the single-dose approach used for some acute genital infections must not be assumed suitable for recurrent thrush, invasive disease or every fungal infection.

Why diagnosis matters

Different Candida species can have different susceptibility to fluconazole. Persistent or recurrent symptoms need assessment rather than repeated self-treatment. The product label also covers other fungal diseases and specialist prevention uses; those uses involve different regimens and sometimes different formulations. The capsule strength alone does not identify a correct course. This summary does not provide a personal treatment schedule or establish approval for every indication in every country.

Side effects and urgent warnings

Headache, abdominal discomfort, nausea, diarrhoea and rash are among the reported common effects. Liver injury, severe allergic reactions and serious skin reactions can occur. Jaundice, a widespread blistering rash, facial swelling or breathing difficulty require prompt medical help. Fluconazole can prolong cardiac repolarisation, especially where other risk factors exist. Fainting or a new sustained irregular heartbeat should be assessed urgently.

Interactions, pregnancy and breastfeeding

Fluconazole inhibits several drug-metabolising enzymes. Warfarin, certain sedatives, transplant medicines and some diabetes medicines may need extra monitoring or adjustment by the prescriber. The UK label prohibits particular combinations, including erythromycin, pimozide, quinidine and cisapride; this does not mean every medicine in a broad class has the same restriction. Its interaction effects can persist after the last capsule. Oral fluconazole should not be presumed safe during pregnancy: the reviewed label limits short courses to clear necessity and applies stricter conditions to prolonged or high-dose use. Breastfeeding advice differs between a single 150 mg dose and repeated or high-dose courses. Discuss pregnancy plans and feeding with a healthcare professional before treatment.

Sources

• Pfizer: Diflucan 150 mg hard capsules — UK SmPC — Text revised February 2024; emc updated 24 February 2024
• Pfizer: Diflucan capsules — UK patient leaflet — Patient leaflet listed on emc 22 February 2024; checked 30 October 2026

Source check: 30 October 2026. This records a source check, not a clinical review by a doctor or pharmacist. Follow the leaflet for the exact product supplied to you.