Diflucan 150 mg (Fluconazole) and Tofacitinib: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Fluconazole inhibits CYP3A4 and CYP2C19, increasing tofacitinib exposure.
Clinical significance and safety
Diflucan 150 mg contains fluconazole, the example specifically listed for combined moderate CYP3A4 and strong CYP2C19 inhibition. Tofacitinib exposure can increase, and the prescriber may need to modify the regimen and monitor for adverse reactions. Do not assume a single antifungal dose makes the combination irrelevant.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.