Acalabrutinib and Nexium (Esomeprazole) (Nexium 20 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Increased gastric pH reduces absorption of the original acalabrutinib hard-capsule formulation.
Clinical significance and safety
Avoid combining the original acalabrutinib hard capsules with the proton-pump inhibitor in Acalabrutinib plus Nexium (Esomeprazole). Simply separating the doses may not prevent the interaction because acid suppression lasts longer. The newer film-coated acalabrutinib tablet does not have the same acid-reducer restriction. Ask the pharmacist to confirm the exact formulation before applying this warning.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.