Acalabrutinib and Warfarin (Coumadin 5 mg): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
BTK-inhibitor-associated bleeding risk can combine with anticoagulation.
Clinical significance and safety
The EMA acalabrutinib product information states that vitamin K antagonists such as warfarin should not be administered together with acalabrutinib. This applies to Acalabrutinib with Warfarin (Coumadin 5 mg). The relevant specialists should arrange an alternative anticoagulation plan when appropriate. Do not stop an anticoagulant on your own, because doing so can also cause serious harm.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.