Bosentan and Diflucan 150 mg (Fluconazole): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Inhibiting both CYP2C9 and CYP3A can increase bosentan exposure.
Clinical significance and safety
Bosentan and Diflucan 150 mg (Fluconazole): Tracleer information does not recommend bosentan with fluconazole because exposure may substantially increase. A clinician should review the antifungal and the full medicine list. Jaundice, marked weakness or fainting needs prompt assessment. Do not change prescribed medicines yourself.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.