Diflucan 150 mg (Fluconazole) and Ribociclib: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Moderate CYP3A inhibition may increase ribociclib exposure.
Clinical significance and safety
With Diflucan 150 mg (Fluconazole) and Ribociclib, assess ribociclib adverse effects and the need for ECG and electrolyte monitoring. The EMA product information does not require a routine starting-dose adjustment with a moderate CYP3A inhibitor, but recommends monitoring for adverse reactions. The treating team should decide whether later treatment modification is needed.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.