Aldactone (Spironolactone) (Aldactone 25 mg) and Treprostinil: interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Diuretic-related volume reduction and treprostinil vasodilation can increase blood-pressure lowering.
Clinical significance and safety
Aldactone (Spironolactone) and Treprostinil: Treprostinil and diuretics may be deliberately combined in specialist treatment. Blood pressure, fluid status and dizziness or fainting should be monitored. Do not change fluid intake or infusion or diuretic doses yourself; the specialist should determine the plan.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.