Cariprazine and Diflucan 150 mg (Fluconazole): interaction and safety
This source-based reference is not a personal treatment recommendation. The relevance and management of an interaction depend on the exact products, route, dose and clinical situation.
Interaction mechanism
Moderate CYP3A4 inhibition may increase exposure to cariprazine and its active metabolites.
Clinical significance and safety
Cariprazine and Diflucan 150 mg (Fluconazole): Moderate CYP3A4 inhibition may increase exposure to cariprazine and its active metabolites. Changes in exposure can affect tolerability or treatment response. The prescriber must check the exact inhibitor, formulation, dose and timing against the cited product information; doses should not be adjusted without that review. Cariprazine and its active metabolites persist for a long time, so the effect of starting or stopping a moderate inhibitor may take several weeks to be fully reflected. Ask a pharmacist or prescriber to review the full medicine list before adding or changing treatment.
Using this information
This is a source-based reference record, not a recommendation to combine, stop or change medicines. A missing interaction record does not establish safe use. A qualified healthcare professional should consider the exact products, doses, other medicines and individual health circumstances.