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Lasmiditan

What is lasmiditan used for?

Lasmiditan is a serotonin 5-HT1F receptor agonist, also called a ditan, used for the acute treatment of migraine with or without aura in adults. It is not a triptan and is not described in the US REYVOW label as a preventive treatment. Similar treatment goals do not make migraine medicines interchangeable. The diagnosis and choice of attack treatment should be confirmed by a qualified clinician.

The driving restriction is essential

Lasmiditan can impair driving even when a person believes that they feel normal. The US label instructs patients not to drive or operate machinery for at least eight hours after every dose. Someone who cannot follow that restriction should not take the medicine. This is a fixed safety precaution, not a suggestion to judge driving ability by how sleepy the person feels. Dizziness, fatigue, tingling and sedation are common adverse reactions.

Which combinations need review?

Other CNS depressants can add to sedation and impaired coordination. Serotonergic medicines, including several antidepressant classes and trazodone, can increase the risk of serotonin syndrome. Medicines that slow the heart rate need caution if a further reduction would be important. Lasmiditan is also not recommended with P-glycoprotein substrates such as digoxin where a small concentration change may produce serious toxicity. These warnings have different mechanisms and should be checked against the complete medicine list.

Symptoms that should not be ignored

Agitation or marked confusion together with fever, muscle stiffness, tremor or poor coordination needs urgent assessment because serotonin syndrome is possible. A very slow or irregular pulse, fainting or severe dizziness also warrants prompt attention. Excessive sleepiness or breathing difficulty after combining sedating medicines should not be dismissed as a routine treatment effect. A person should not drive themselves for assessment when driving is restricted or they are impaired.

Other questions for the prescriber

Human pregnancy information and human lactation information are limited. Severe liver impairment is another important prescribing consideration. Discuss how frequently attack medicine is being used, because frequent acute treatment can contribute to medication-overuse headache. This page follows the current US tablet labeling and does not establish suitability under another country’s authorization. It is a source-based overview rather than a personal dosing instruction or a recommendation to combine medicines.

Sources and scope

Checked 4 November 2026. REYVOW (lasmiditan) — US prescribing information, DailyMed. Source checking is separate from a clinical examination or expert review.

Sources